BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

109 related articles for article (PubMed ID: 24763361)

  • 1. Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?
    Florence X; Desvaux V; Goffin E; de Tullio P; Pirotte B; Lebrun P
    Eur J Med Chem; 2014 Jun; 80():36-46. PubMed ID: 24763361
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
    Sebille S; Gall D; de Tullio P; Florence X; Lebrun P; Pirotte B
    J Med Chem; 2006 Jul; 49(15):4690-7. PubMed ID: 16854075
    [TBL] [Abstract][Full Text] [Related]  

  • 3. New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
    Sebille S; de Tullio P; Florence X; Becker B; Antoine MH; Michaux C; Wouters J; Pirotte B; Lebrun P
    Bioorg Med Chem; 2008 May; 16(10):5704-19. PubMed ID: 18406154
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.
    Florence X; Dilly S; de Tullio P; Pirotte B; Lebrun P
    Bioorg Med Chem; 2011 Jul; 19(13):3919-28. PubMed ID: 21664825
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.
    Pirotte B; Florence X; Goffin E; Medeiros MB; de Tullio P; Lebrun P
    Eur J Med Chem; 2016 Oct; 121():338-351. PubMed ID: 27267004
    [TBL] [Abstract][Full Text] [Related]  

  • 6. New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.
    Florence X; Sebille S; Tullio Pd; Lebrun P; Pirotte B
    Bioorg Med Chem; 2009 Nov; 17(22):7723-31. PubMed ID: 19822435
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.
    Sebille S; de Tullio P; Becker B; Antoine MH; Boverie S; Pirotte B; Lebrun P
    J Med Chem; 2005 Jan; 48(2):614-21. PubMed ID: 15658874
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
    Khelili S; Florence X; Bouhadja M; Abdelaziz S; Mechouch N; Mohamed Y; de Tullio P; Lebrun P; Pirotte B
    Bioorg Med Chem; 2008 Jun; 16(11):6124-30. PubMed ID: 18479927
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
    Pirotte B; de Tullio P; Boverie S; Michaux C; Lebrun P
    J Med Chem; 2011 May; 54(9):3188-99. PubMed ID: 21428460
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.
    Khelili S; Lebrun P; de Tullio P; Pirotte B
    Bioorg Med Chem; 2006 May; 14(10):3530-4. PubMed ID: 16455262
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis.
    Bouhedja M; Peres B; Fhayli W; Ghandour Z; Boumendjel A; Faury G; Khelili S
    Eur J Med Chem; 2018 Jan; 144():774-796. PubMed ID: 29291445
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 2-alkyl-3-Alkylamino-2H-Benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?
    Ouedraogo R; Becker B; Boverie S; Somers F; Antoine MH; Pirotte B; Lebrun P; de Tullio P
    Biol Chem; 2002 Nov; 383(11):1759-68. PubMed ID: 12530541
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Deciphering Structure-Activity Relationships in a Series of 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants.
    Pirotte B; Florence X; Goffin E; Lebrun P
    ChemMedChem; 2017 Nov; 12(21):1810-1817. PubMed ID: 28967705
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.
    Pirotte B; Ouedraogo R; de Tullio P; Khelili S; Somers F; Boverie S; Dupont L; Fontaine J; Damas J; Lebrun P
    J Med Chem; 2000 Apr; 43(8):1456-66. PubMed ID: 10780901
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potassium channel activators based on the benzopyran substructure: synthesis and activity of the C-8 substituent.
    Thompson R; Doggrell S; Hoberg JO
    Bioorg Med Chem; 2003 Apr; 11(8):1663-8. PubMed ID: 12659752
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Recent developments in the chemistry of potassium channel activators: the cromakalim analogs.
    Sebille S; De Tullio P; Boverie S; Antoine MH; Lebrun P; Pirotte B
    Curr Med Chem; 2004 May; 11(9):1213-22. PubMed ID: 15134515
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Interaction of diazoxide and cromakalim with ATP-regulated K+ channels in rodent and clonal insulin-secreting cells.
    Jaggar JH; Harding EA; Ayton BJ; Dunne MJ
    J Mol Endocrinol; 1993 Feb; 10(1):59-70. PubMed ID: 8452640
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide.
    Quast U; Cook NS
    J Pharmacol Exp Ther; 1989 Jul; 250(1):261-71. PubMed ID: 2501478
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.
    de Tullio P; Servais AC; Fillet M; Gillotin F; Somers F; Chiap P; Lebrun P; Pirotte B
    J Med Chem; 2011 Dec; 54(24):8353-61. PubMed ID: 22077416
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers.
    Caliendo G; Perissutti E; Santagada V; Fiorino F; Severino B; di Villa Bianca Rd; Lippolis L; Pinto A; Sorrentino R
    Bioorg Med Chem; 2002 Aug; 10(8):2663-9. PubMed ID: 12057655
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.