230 related articles for article (PubMed ID: 24766193)
1. Etoposide quinone is a covalent poison of human topoisomerase IIβ.
Smith NA; Byl JA; Mercer SL; Deweese JE; Osheroff N
Biochemistry; 2014 May; 53(19):3229-36. PubMed ID: 24766193
[TBL] [Abstract][Full Text] [Related]
2. Etoposide quinone is a redox-dependent topoisomerase II poison.
Jacob DA; Mercer SL; Osheroff N; Deweese JE
Biochemistry; 2011 Jun; 50(25):5660-7. PubMed ID: 21595477
[TBL] [Abstract][Full Text] [Related]
3. 1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases.
Collins JA; Osheroff N
Chem Res Toxicol; 2021 Apr; 34(4):1082-1090. PubMed ID: 33760604
[TBL] [Abstract][Full Text] [Related]
4. Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ.
Oviatt AA; Kuriappan JA; Minniti E; Vann KR; Onuorah P; Minarini A; De Vivo M; Osheroff N
Bioorg Med Chem Lett; 2018 Sep; 28(17):2961-2968. PubMed ID: 30006062
[TBL] [Abstract][Full Text] [Related]
5. Two-Mechanism Model for the Interaction of Etoposide Quinone with Topoisomerase IIα.
Gibson EG; King MM; Mercer SL; Deweese JE
Chem Res Toxicol; 2016 Sep; 29(9):1541-8. PubMed ID: 27533850
[TBL] [Abstract][Full Text] [Related]
6. Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism.
Lindsey RH; Pendleton M; Ashley RE; Mercer SL; Deweese JE; Osheroff N
Biochemistry; 2014 Oct; 53(41):6595-602. PubMed ID: 25280269
[TBL] [Abstract][Full Text] [Related]
7. Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
Bender RP; Osheroff N
Chem Res Toxicol; 2007 Jun; 20(6):975-81. PubMed ID: 17516663
[TBL] [Abstract][Full Text] [Related]
8. Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity.
Cowell IG; Sondka Z; Smith K; Lee KC; Manville CM; Sidorczuk-Lesthuruge M; Rance HA; Padget K; Jackson GH; Adachi N; Austin CA
Proc Natl Acad Sci U S A; 2012 Jun; 109(23):8989-94. PubMed ID: 22615413
[TBL] [Abstract][Full Text] [Related]
9. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.
Bender RP; Lehmler HJ; Robertson LW; Ludewig G; Osheroff N
Biochemistry; 2006 Aug; 45(33):10140-52. PubMed ID: 16906772
[TBL] [Abstract][Full Text] [Related]
10. Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints.
Lovett BD; Strumberg D; Blair IA; Pang S; Burden DA; Megonigal MD; Rappaport EF; Rebbeck TR; Osheroff N; Pommier YG; Felix CA
Biochemistry; 2001 Feb; 40(5):1159-70. PubMed ID: 11170441
[TBL] [Abstract][Full Text] [Related]
11. Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites.
Lindsey RH; Bender RP; Osheroff N
Chem Biol Interact; 2005 May; 153-154():197-205. PubMed ID: 15935817
[TBL] [Abstract][Full Text] [Related]
12. Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.
Pitts SL; Jablonksy MJ; Duca M; Dauzonne D; Monneret C; Arimondo PB; Anklin C; Graves DE; Osheroff N
Biochemistry; 2011 Jun; 50(22):5058-66. PubMed ID: 21548574
[TBL] [Abstract][Full Text] [Related]
13. DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action.
Byl JA; Cline SD; Utsugi T; Kobunai T; Yamada Y; Osheroff N
Biochemistry; 2001 Jan; 40(3):712-8. PubMed ID: 11170388
[TBL] [Abstract][Full Text] [Related]
14. N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison.
Bender RP; Lindsey RH; Burden DA; Osheroff N
Biochemistry; 2004 Mar; 43(12):3731-9. PubMed ID: 15035644
[TBL] [Abstract][Full Text] [Related]
15. Etoposide catechol is an oxidizable topoisomerase II poison.
Jacob DA; Gibson EG; Mercer SL; Deweese JE
Chem Res Toxicol; 2013 Aug; 26(8):1156-8. PubMed ID: 23863110
[TBL] [Abstract][Full Text] [Related]
16. Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.
Gentry AC; Pitts SL; Jablonsky MJ; Bailly C; Graves DE; Osheroff N
Biochemistry; 2011 Apr; 50(15):3240-9. PubMed ID: 21413765
[TBL] [Abstract][Full Text] [Related]
17. Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.
Ketron AC; Denny WA; Graves DE; Osheroff N
Biochemistry; 2012 Feb; 51(8):1730-9. PubMed ID: 22304499
[TBL] [Abstract][Full Text] [Related]
18. Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.
Infante Lara L; Fenner S; Ratcliffe S; Isidro-Llobet A; Hann M; Bax B; Osheroff N
Nucleic Acids Res; 2018 Mar; 46(5):2218-2233. PubMed ID: 29447373
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors.
Park S; Hong E; Kwak SY; Jun KY; Lee ES; Kwon Y; Na Y
Eur J Med Chem; 2016 Nov; 123():211-225. PubMed ID: 27484510
[TBL] [Abstract][Full Text] [Related]
20. The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells.
Bandele OJ; Osheroff N
Biochemistry; 2008 Nov; 47(45):11900-8. PubMed ID: 18922022
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]