176 related articles for article (PubMed ID: 24767541)
1. Defining critical residues for substrate binding to 1-deoxy-D-xylulose 5-phosphate synthase--active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate.
Basta LAB; Patel H; Kakalis L; Jordan F; Meyers CLF
FEBS J; 2014 Jun; 281(12):2820-2837. PubMed ID: 24767541
[TBL] [Abstract][Full Text] [Related]
2. Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria.
DeColli AA; Nemeria NS; Majumdar A; Gerfen GJ; Jordan F; Freel Meyers CL
J Biol Chem; 2018 Jul; 293(28):10857-10869. PubMed ID: 29784878
[TBL] [Abstract][Full Text] [Related]
3. Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate.
Patel H; Nemeria NS; Brammer LA; Freel Meyers CL; Jordan F
J Am Chem Soc; 2012 Nov; 134(44):18374-9. PubMed ID: 23072514
[TBL] [Abstract][Full Text] [Related]
4. Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase.
Toci EM; Austin SL; Majumdar A; Woodcock HL; Freel Meyers CL
Biochemistry; 2024 Mar; 63(5):671-687. PubMed ID: 38393327
[TBL] [Abstract][Full Text] [Related]
5. Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase.
DeColli AA; Zhang X; Heflin KL; Jordan F; Freel Meyers CL
Biochemistry; 2019 Dec; 58(49):4970-4982. PubMed ID: 31724401
[TBL] [Abstract][Full Text] [Related]
6. Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.
Sanders S; Vierling RJ; Bartee D; DeColli AA; Harrison MJ; Aklinski JL; Koppisch AT; Freel Meyers CL
ACS Infect Dis; 2017 Jul; 3(7):467-478. PubMed ID: 28636325
[TBL] [Abstract][Full Text] [Related]
7. X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.
Chen PY; DeColli AA; Freel Meyers CL; Drennan CL
J Biol Chem; 2019 Aug; 294(33):12405-12414. PubMed ID: 31239351
[TBL] [Abstract][Full Text] [Related]
8. Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.
Zhou J; Yang L; DeColli A; Freel Meyers C; Nemeria NS; Jordan F
Proc Natl Acad Sci U S A; 2017 Aug; 114(35):9355-9360. PubMed ID: 28808005
[TBL] [Abstract][Full Text] [Related]
9. DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.
Morris F; Vierling R; Boucher L; Bosch J; Freel Meyers CL
Chembiochem; 2013 Jul; 14(11):1309-15. PubMed ID: 23824585
[TBL] [Abstract][Full Text] [Related]
10. Targeting the Unique Mechanism of Bacterial 1-Deoxy-d-xylulose-5-phosphate Synthase.
Bartee D; Freel Meyers CL
Biochemistry; 2018 Jul; 57(29):4349-4356. PubMed ID: 29944345
[TBL] [Abstract][Full Text] [Related]
11. Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism.
Bartee D; Freel Meyers CL
Acc Chem Res; 2018 Oct; 51(10):2546-2555. PubMed ID: 30203647
[TBL] [Abstract][Full Text] [Related]
12. Antibacterial Target DXP Synthase Catalyzes the Cleavage of d-Xylulose 5-Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction.
Johnston ML; Bonett EM; DeColli AA; Freel Meyers CL
Biochemistry; 2022 Sep; 61(17):1810-1823. PubMed ID: 35998648
[TBL] [Abstract][Full Text] [Related]
13. Rhodobacter capsulatus 1-deoxy-D-xylulose 5-phosphate synthase: steady-state kinetics and substrate binding.
Eubanks LM; Poulter CD
Biochemistry; 2003 Feb; 42(4):1140-9. PubMed ID: 12549936
[TBL] [Abstract][Full Text] [Related]
14. Feedback inhibition of deoxy-D-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathway.
Banerjee A; Wu Y; Banerjee R; Li Y; Yan H; Sharkey TD
J Biol Chem; 2013 Jun; 288(23):16926-16936. PubMed ID: 23612965
[TBL] [Abstract][Full Text] [Related]
15. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.
Sprenger GA; Schörken U; Wiegert T; Grolle S; de Graaf AA; Taylor SV; Begley TP; Bringer-Meyer S; Sahm H
Proc Natl Acad Sci U S A; 1997 Nov; 94(24):12857-62. PubMed ID: 9371765
[TBL] [Abstract][Full Text] [Related]
16. C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models.
Zhang S; Liu M; Yan Y; Zhang Z; Jordan F
J Biol Chem; 2004 Dec; 279(52):54312-8. PubMed ID: 15501823
[TBL] [Abstract][Full Text] [Related]
17. Intermediates and transition states in thiamin diphosphate-dependent decarboxylases. A kinetic and NMR study on wild-type indolepyruvate decarboxylase and variants using indolepyruvate, benzoylformate, and pyruvate as substrates.
Schütz A; Golbik R; König S; Hübner G; Tittmann K
Biochemistry; 2005 Apr; 44(16):6164-79. PubMed ID: 15835904
[TBL] [Abstract][Full Text] [Related]
18. Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase.
Bartee D; Morris F; Al-Khouja A; Freel Meyers CL
Chembiochem; 2015 Aug; 16(12):1771-81. PubMed ID: 26174207
[TBL] [Abstract][Full Text] [Related]
19. Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism.
Johnston ML; Freel Meyers CL
Biochemistry; 2021 Mar; 60(12):929-939. PubMed ID: 33660509
[TBL] [Abstract][Full Text] [Related]
20. Engineering of Recombinant Poplar Deoxy-D-Xylulose-5-Phosphate Synthase (PtDXS) by Site-Directed Mutagenesis Improves Its Activity.
Banerjee A; Preiser AL; Sharkey TD
PLoS One; 2016; 11(8):e0161534. PubMed ID: 27548482
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
