154 related articles for article (PubMed ID: 24773261)
1. Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations.
Jiménez VA; Alderete JB; Navarrete KR
J Biomol Struct Dyn; 2015; 33(4):789-803. PubMed ID: 24773261
[TBL] [Abstract][Full Text] [Related]
2. Molecular modeling study on the tubulin-binding modes of epothilone derivatives: Insight into the structural basis for epothilones activity.
Jiménez VA; Alderete JB; Navarrete KR
Chem Biol Drug Des; 2017 Dec; 90(6):1247-1259. PubMed ID: 28632973
[TBL] [Abstract][Full Text] [Related]
3. The binding mode of side chain- and C3-modified epothilones to tubulin.
Erdélyi M; Navarro-Vázquez A; Pfeiffer B; Kuzniewski CN; Felser A; Widmer T; Gertsch J; Pera B; Díaz JF; Altmann KH; Carlomagno T
ChemMedChem; 2010 Jun; 5(6):911-20. PubMed ID: 20432490
[TBL] [Abstract][Full Text] [Related]
4. Structural insight into the mechanism of epothilone A bound to beta-tubulin and its mutants at Arg282Gln and Thr274Ile.
Shi G; Wang Y; Jin Y; Chi S; Shi Q; Ge M; Wang S; Zhang X; Xu S
J Biomol Struct Dyn; 2012; 30(5):559-73. PubMed ID: 22731768
[TBL] [Abstract][Full Text] [Related]
5. Structural basis for drug resistance conferred by β-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B.
Navarrete KR; Alderete JB; Jiménez VA
J Biomol Struct Dyn; 2015; 33(12):2530-40. PubMed ID: 26081685
[TBL] [Abstract][Full Text] [Related]
6. Computational study of binding of epothilone A to β-tubulin.
Kamel K; Kolinski A
Acta Biochim Pol; 2011; 58(2):255-60. PubMed ID: 21633729
[TBL] [Abstract][Full Text] [Related]
7. Synthesis & antitumor activity of epothilones B and D and their analogs.
Cheng H; Huang G
Future Med Chem; 2018 Jun; 10(12):1483-1496. PubMed ID: 29788770
[TBL] [Abstract][Full Text] [Related]
8. High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.
Xiao Q; Xue T; Shuai W; Wu C; Zhang Z; Zhang T; Zeng S; Sun B; Wang Y
Biochem Biophys Res Commun; 2021 Jan; 534():330-336. PubMed ID: 33272565
[TBL] [Abstract][Full Text] [Related]
9. Molecular mechanism of action of microtubule-stabilizing anticancer agents.
Prota AE; Bargsten K; Zurwerra D; Field JJ; Díaz JF; Altmann KH; Steinmetz MO
Science; 2013 Feb; 339(6119):587-90. PubMed ID: 23287720
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.
Pfeiffer B; Hauenstein K; Merz P; Gertsch J; Altmann KH
Bioorg Med Chem Lett; 2009 Jul; 19(14):3760-3. PubMed ID: 19433359
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues.
Woods LM; Arico JW; Frein JD; Sackett DL; Taylor RE
Int J Mol Sci; 2017 Mar; 18(3):. PubMed ID: 28304361
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of isotopically labeled epothilones.
Ganesh T; Brodie PJ; Banerjee A; Bane S; Kingston DG
J Labelled Comp Radiopharm; 2014 Feb; 57(2):78-81. PubMed ID: 24307484
[TBL] [Abstract][Full Text] [Related]
13. Comparative binding energy (COMBINE) analysis supports a proposal for the binding mode of epothilones to β-tubulin.
Coderch C; Klett J; Morreale A; Fernando Díaz J; Gago F
ChemMedChem; 2012 May; 7(5):836-43. PubMed ID: 22431398
[TBL] [Abstract][Full Text] [Related]
14. Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.
Zúñiga MA; Alderete JB; Jaña GA; Jiménez VA
J Comput Aided Mol Des; 2017 Jul; 31(7):643-652. PubMed ID: 28597356
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).
Jantsch A; Nieto L; Gertsch J; Rodríguez-Salarichs J; Matesanz R; Jiménez-Barbero J; Díaz JF; Canales Á; Altmann KH
Molecules; 2016 Aug; 21(8):. PubMed ID: 27527129
[TBL] [Abstract][Full Text] [Related]
16. Conformational Properties of the Chemotherapeutic Drug Analogue Epothilone A: How to Model a Flexible Protein Ligand Using Scarcely Available Experimental Data.
Dolenc J; van Gunsteren WF; Prota AE; Steinmetz MO; Missimer JH
J Chem Inf Model; 2019 May; 59(5):2218-2230. PubMed ID: 30855963
[TBL] [Abstract][Full Text] [Related]
17. A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.
Giannakakou P; Gussio R; Nogales E; Downing KH; Zaharevitz D; Bollbuck B; Poy G; Sackett D; Nicolaou KC; Fojo T
Proc Natl Acad Sci U S A; 2000 Mar; 97(6):2904-9. PubMed ID: 10688884
[TBL] [Abstract][Full Text] [Related]
18. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.
Nettles JH; Li H; Cornett B; Krahn JM; Snyder JP; Downing KH
Science; 2004 Aug; 305(5685):866-9. PubMed ID: 15297674
[TBL] [Abstract][Full Text] [Related]
19. Theoretical insight into the structural mechanism for the binding of vinblastine with tubulin.
Chi S; Xie W; Zhang J; Xu S
J Biomol Struct Dyn; 2015; 33(10):2234-54. PubMed ID: 25588192
[TBL] [Abstract][Full Text] [Related]
20. Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
Khrapunovich-Baine M; Menon V; Yang CP; Northcote PT; Miller JH; Angeletti RH; Fiser A; Horwitz SB; Xiao H
J Biol Chem; 2011 Apr; 286(13):11765-78. PubMed ID: 21245138
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]