BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 24775307)

  • 1. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.
    Rafferty SW; Eisner JR; Moore WR; Schotzinger RJ; Hoekstra WJ
    Bioorg Med Chem Lett; 2014 Jun; 24(11):2444-7. PubMed ID: 24775307
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.
    Hille UE; Hu Q; Vock C; Negri M; Bartels M; Müller-Vieira U; Lauterbach T; Hartmann RW
    Eur J Med Chem; 2009 Jul; 44(7):2765-75. PubMed ID: 19211174
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.
    Pinto-Bazurco Mendieta MA; Negri M; Jagusch C; Müller-Vieira U; Lauterbach T; Hartmann RW
    J Med Chem; 2008 Aug; 51(16):5009-18. PubMed ID: 18672868
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CYP17 inhibitors--abiraterone, C17,20-lyase inhibitors and multi-targeting agents.
    Yin L; Hu Q
    Nat Rev Urol; 2014 Jan; 11(1):32-42. PubMed ID: 24276076
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
    Njar VC; Kato K; Nnane IP; Grigoryev DN; Long BJ; Brodie AM
    J Med Chem; 1998 Mar; 41(6):902-12. PubMed ID: 9526564
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases.
    Salvador JA; Pinto RM; Silvestre SM
    J Steroid Biochem Mol Biol; 2013 Sep; 137():199-222. PubMed ID: 23688836
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.
    Hu Q; Yin L; Jagusch C; Hille UE; Hartmann RW
    J Med Chem; 2010 Jul; 53(13):5049-53. PubMed ID: 20550118
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibitors of 17alpha-hydroxylase/17,20-lyase (CYP17): potential agents for the treatment of prostate cancer.
    Njar VC; Brodie AM
    Curr Pharm Des; 1999 Mar; 5(3):163-80. PubMed ID: 10066888
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.
    Yamaoka M; Hara T; Hitaka T; Kaku T; Takeuchi T; Takahashi J; Asahi S; Miki H; Tasaka A; Kusaka M
    J Steroid Biochem Mol Biol; 2012 Apr; 129(3-5):115-28. PubMed ID: 22249003
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hits identified in library screening demonstrate selective CYP17A1 lyase inhibition.
    Krug SJ; Hu Q; Hartmann RW
    J Steroid Biochem Mol Biol; 2013 Mar; 134():75-9. PubMed ID: 23142656
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CYP17 inhibitors for prostate cancer therapy.
    Vasaitis TS; Bruno RD; Njar VC
    J Steroid Biochem Mol Biol; 2011 May; 125(1-2):23-31. PubMed ID: 21092758
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.
    Kaku T; Hitaka T; Ojida A; Matsunaga N; Adachi M; Tanaka T; Hara T; Yamaoka M; Kusaka M; Okuda T; Asahi S; Furuya S; Tasaka A
    Bioorg Med Chem; 2011 Nov; 19(21):6383-99. PubMed ID: 21978946
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
    Handratta VD; Vasaitis TS; Njar VC; Gediya LK; Kataria R; Chopra P; Newman D; Farquhar R; Guo Z; Qiu Y; Brodie AM
    J Med Chem; 2005 Apr; 48(8):2972-84. PubMed ID: 15828836
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeting CYP17: established and novel approaches in prostate cancer.
    Yap TA; Carden CP; Attard G; de Bono JS
    Curr Opin Pharmacol; 2008 Aug; 8(4):449-57. PubMed ID: 18619560
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21.
    Drăgan CA; Hartmann RW; Bureik M
    J Enzyme Inhib Med Chem; 2006 Oct; 21(5):547-56. PubMed ID: 17194026
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer.
    Attard G; Reid AH; Auchus RJ; Hughes BA; Cassidy AM; Thompson E; Oommen NB; Folkerd E; Dowsett M; Arlt W; de Bono JS
    J Clin Endocrinol Metab; 2012 Feb; 97(2):507-16. PubMed ID: 22170708
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 17alpha-hydroxylase/17,20-lyase (p450(17alpha)) inhibitors in the treatment of prostate cancer: a review.
    Owen CP
    Anticancer Agents Med Chem; 2009 Jul; 9(6):613-26. PubMed ID: 19601745
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.
    Clement OO; Freeman CM; Hartmann RW; Handratta VD; Vasaitis TS; Brodie AM; Njar VC
    J Med Chem; 2003 Jun; 46(12):2345-51. PubMed ID: 12773039
    [TBL] [Abstract][Full Text] [Related]  

  • 19. CYP17 inhibitors for prostate cancer treatment--an update.
    Moreira VM; Salvador JA; Vasaitis TS; Njar VC
    Curr Med Chem; 2008; 15(9):868-99. PubMed ID: 18473796
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The role of abiraterone acetate in the management of prostate cancer: a critical analysis of the literature.
    Sonpavde G; Attard G; Bellmunt J; Mason MD; Malavaud B; Tombal B; Sternberg CN
    Eur Urol; 2011 Aug; 60(2):270-8. PubMed ID: 21550166
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.