BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 24780582)

  • 1. The role of surface electrostatics on the stability, function and regulation of human cystathionine β-synthase, a complex multidomain and oligomeric protein.
    Pey AL; Majtan T; Kraus JP
    Biochim Biophys Acta; 2014 Sep; 1844(9):1453-62. PubMed ID: 24780582
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases.
    Majtan T; Pey AL; Fernández R; Fernández JA; Martínez-Cruz LA; Kraus JP
    PLoS One; 2014; 9(8):e105290. PubMed ID: 25122507
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM.
    Pey AL; Majtan T; Sanchez-Ruiz JM; Kraus JP
    Biochem J; 2013 Jan; 449(1):109-21. PubMed ID: 22985361
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding.
    Pey AL; Martínez-Cruz LA; Kraus JP; Majtan T
    FEBS Lett; 2016 Dec; 590(24):4461-4471. PubMed ID: 27861796
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine.
    Ereño-Orbea J; Majtan T; Oyenarte I; Kraus JP; Martínez-Cruz LA
    Proc Natl Acad Sci U S A; 2014 Sep; 111(37):E3845-52. PubMed ID: 25197074
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Insights into the regulatory domain of cystathionine Beta-synthase: characterization of six variant proteins.
    Mendes MI; Santos AS; Smith DE; Lino PR; Colaço HG; de Almeida IT; Vicente JB; Salomons GS; Rivera I; Blom HJ; Leandro P
    Hum Mutat; 2014 Oct; 35(10):1195-202. PubMed ID: 25044645
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria.
    Majtan T; Pey AL; Kraus JP
    Biochimie; 2016 Jul; 126():6-13. PubMed ID: 26805382
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif.
    Smith AT; Majtan T; Freeman KM; Su Y; Kraus JP; Burstyn JN
    Inorg Chem; 2011 May; 50(10):4417-27. PubMed ID: 21480614
    [TBL] [Abstract][Full Text] [Related]  

  • 9. An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii.
    Manszewski T; Singh K; Imiolczyk B; Jaskolski M
    Acta Crystallogr D Biol Crystallogr; 2015 Dec; 71(Pt 12):2422-32. PubMed ID: 26627650
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions.
    Majtan T; Pey AL; Ereño-Orbea J; Martínez-Cruz LA; Kraus JP
    Curr Drug Targets; 2016; 17(13):1455-70. PubMed ID: 26931358
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria.
    Majtan T; Pey AL; Gimenez-Mascarell P; Martínez-Cruz LA; Szabo C; Kožich V; Kraus JP
    Handb Exp Pharmacol; 2018; 245():345-383. PubMed ID: 29119254
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cross-talk between the catalytic core and the regulatory domain in cystathionine β-synthase: study by differential covalent labeling and computational modeling.
    Hnízda A; Spiwok V; Jurga V; Kozich V; Kodícek M; Kraus JP
    Biochemistry; 2010 Dec; 49(49):10526-34. PubMed ID: 21062078
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation.
    McCorvie TJ; Kopec J; Hyung SJ; Fitzpatrick F; Feng X; Termine D; Strain-Damerell C; Vollmar M; Fleming J; Janz JM; Bulawa C; Yue WW
    J Biol Chem; 2014 Dec; 289(52):36018-30. PubMed ID: 25336647
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli.
    Belew MS; Quazi FI; Willmore WG; Aitken SM
    Protein Expr Purif; 2009 Apr; 64(2):139-45. PubMed ID: 19010420
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region.
    Janosík M; Kery V; Gaustadnes M; Maclean KN; Kraus JP
    Biochemistry; 2001 Sep; 40(35):10625-33. PubMed ID: 11524006
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation.
    Jhee KH; McPhie P; Miles EW
    Biochemistry; 2000 Aug; 39(34):10548-56. PubMed ID: 10956046
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
    Maclean KN; Jiang H; Phinney WN; Mclagan BM; Roede JR; Stabler SP
    Mol Genet Metab; 2021 Feb; 132(2):128-138. PubMed ID: 33483253
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of cystathionine beta-synthase in homocysteine metabolism.
    Jhee KH; Kruger WD
    Antioxid Redox Signal; 2005; 7(5-6):813-22. PubMed ID: 15890029
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
    Koutmos M; Kabil O; Smith JL; Banerjee R
    Proc Natl Acad Sci U S A; 2010 Dec; 107(49):20958-63. PubMed ID: 21081698
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mouse modeling and structural analysis of the p.G307S mutation in human cystathionine β-synthase (
    Gupta S; Kelow S; Wang L; Andrake MD; Dunbrack RL; Kruger WD
    J Biol Chem; 2018 Sep; 293(36):13921-13931. PubMed ID: 30030379
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.