230 related articles for article (PubMed ID: 24781018)
1. The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells.
López-Guerra M; Xargay-Torrent S; Rosich L; Montraveta A; Roldán J; Matas-Céspedes A; Villamor N; Aymerich M; López-Otín C; Pérez-Galán P; Roué G; Campo E; Colomer D
Leukemia; 2015 Jan; 29(1):96-106. PubMed ID: 24781018
[TBL] [Abstract][Full Text] [Related]
2. Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells.
López-Guerra M; Xargay-Torrent S; Fuentes P; Roldán J; González-Farré B; Rosich L; Silkenstedt E; García-León MJ; Lee-Vergés E; Giménez N; Giró A; Aymerich M; Villamor N; Delgado J; López-Guillermo A; Puente XS; Campo E; Toribio ML; Colomer D
Oncogene; 2020 Feb; 39(6):1185-1197. PubMed ID: 31616059
[TBL] [Abstract][Full Text] [Related]
3. Constitutive activation of NF-κB signaling by NOTCH1 mutations in chronic lymphocytic leukemia.
Xu ZS; Zhang JS; Zhang JY; Wu SQ; Xiong DL; Chen HJ; Chen ZZ; Zhan R
Oncol Rep; 2015 Apr; 33(4):1609-14. PubMed ID: 25633905
[TBL] [Abstract][Full Text] [Related]
4. Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism.
Secchiero P; Melloni E; di Iasio MG; Tiribelli M; Rimondi E; Corallini F; Gattei V; Zauli G
Blood; 2009 Apr; 113(18):4300-8. PubMed ID: 19190243
[TBL] [Abstract][Full Text] [Related]
5. Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia.
Samon JB; Castillo-Martin M; Hadler M; Ambesi-Impiobato A; Paietta E; Racevskis J; Wiernik PH; Rowe JM; Jakubczak J; Randolph S; Cordon-Cardo C; Ferrando AA
Mol Cancer Ther; 2012 Jul; 11(7):1565-75. PubMed ID: 22504949
[TBL] [Abstract][Full Text] [Related]
6. γ-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation.
Rosati E; Sabatini R; De Falco F; Del Papa B; Falzetti F; Di Ianni M; Cavalli L; Fettucciari K; Bartoli A; Screpanti I; Marconi P
Int J Cancer; 2013 Apr; 132(8):1940-53. PubMed ID: 23001755
[TBL] [Abstract][Full Text] [Related]
7. PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor.
Wang K; Zhang Q; Li D; Ching K; Zhang C; Zheng X; Ozeck M; Shi S; Li X; Wang H; Rejto P; Christensen J; Olson P
Clin Cancer Res; 2015 Mar; 21(6):1487-96. PubMed ID: 25564152
[TBL] [Abstract][Full Text] [Related]
8. Entinostat combined with Fludarabine synergistically enhances the induction of apoptosis in TP53 mutated CLL cells via the HDAC1/HO-1 pathway.
Zhou Z; Fang Q; Li P; Ma D; Zhe N; Ren M; Chen B; He Z; Wang J; Zhong Q; Wang J
Life Sci; 2019 Sep; 232():116583. PubMed ID: 31226417
[TBL] [Abstract][Full Text] [Related]
9. NOTCH1 mutations identify a chronic lymphocytic leukemia patient subset with worse prognosis in the setting of a rituximab-based induction and consolidation treatment.
Bo MD; Del Principe MI; Pozzo F; Ragusa D; Bulian P; Rossi D; Capelli G; Rossi FM; Niscola P; Buccisano F; Bomben R; Zucchetto A; Maurillo L; de Fabritiis P; Amadori S; Gaidano G; Gattei V; Del Poeta G
Ann Hematol; 2014 Oct; 93(10):1765-74. PubMed ID: 24923451
[TBL] [Abstract][Full Text] [Related]
10. NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components.
Pozzo F; Bittolo T; Vendramini E; Bomben R; Bulian P; Rossi FM; Zucchetto A; Tissino E; Degan M; D'Arena G; Di Raimondo F; Zaja F; Pozzato G; Rossi D; Gaidano G; Del Poeta G; Gattei V; Dal Bo M
Leukemia; 2017 Nov; 31(11):2407-2415. PubMed ID: 28321119
[TBL] [Abstract][Full Text] [Related]
11. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.
Hales EC; Taub JW; Matherly LH
Cell Signal; 2014 Jan; 26(1):149-61. PubMed ID: 24140475
[TBL] [Abstract][Full Text] [Related]
12. Frequencies of SF3B1, NOTCH1, MYD88, BIRC3 and IGHV mutations and TP53 disruptions in Chinese with chronic lymphocytic leukemia: disparities with Europeans.
Xia Y; Fan L; Wang L; Gale RP; Wang M; Tian T; Wu W; Yu L; Chen YY; Xu W; Li JY
Oncotarget; 2015 Mar; 6(7):5426-34. PubMed ID: 25605254
[TBL] [Abstract][Full Text] [Related]
13. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.
Wei P; Walls M; Qiu M; Ding R; Denlinger RH; Wong A; Tsaparikos K; Jani JP; Hosea N; Sands M; Randolph S; Smeal T
Mol Cancer Ther; 2010 Jun; 9(6):1618-28. PubMed ID: 20530712
[TBL] [Abstract][Full Text] [Related]
14. Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells.
Han B; Liu SH; Guo WD; Zhang B; Wang JP; Cao YK; Liu J
World J Gastroenterol; 2015 Sep; 21(33):9727-35. PubMed ID: 26361419
[TBL] [Abstract][Full Text] [Related]
15. Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models.
Zhang CC; Pavlicek A; Zhang Q; Lira ME; Painter CL; Yan Z; Zheng X; Lee NV; Ozeck M; Qiu M; Zong Q; Lappin PB; Wong A; Rejto PA; Smeal T; Christensen JG
Clin Cancer Res; 2012 Sep; 18(18):5008-19. PubMed ID: 22806875
[TBL] [Abstract][Full Text] [Related]
16. Notch Inhibitor PF-03084014 Inhibits Hepatocellular Carcinoma Growth and Metastasis via Suppression of Cancer Stemness due to Reduced Activation of Notch1-Stat3.
Wu CX; Xu A; Zhang CC; Olson P; Chen L; Lee TK; Cheung TT; Lo CM; Wang XQ
Mol Cancer Ther; 2017 Aug; 16(8):1531-1543. PubMed ID: 28522590
[TBL] [Abstract][Full Text] [Related]
17. NOTCH1 mutations in CLL associated with trisomy 12.
Balatti V; Bottoni A; Palamarchuk A; Alder H; Rassenti LZ; Kipps TJ; Pekarsky Y; Croce CM
Blood; 2012 Jan; 119(2):329-31. PubMed ID: 22086416
[TBL] [Abstract][Full Text] [Related]
18. NOTCH1 mutations are associated with high CD49d expression in chronic lymphocytic leukemia: link between the NOTCH1 and the NF-κB pathways.
Benedetti D; Tissino E; Pozzo F; Bittolo T; Caldana C; Perini C; Martorelli D; Bravin V; D'Agaro T; Rossi FM; Bomben R; Santinelli E; Zaja F; Pozzato G; Chiarenza A; Di Raimondo F; Del Poeta G; Rossi D; Gaidano G; Dal Bo M; Gattei V; Zucchetto A
Leukemia; 2018 Mar; 32(3):654-662. PubMed ID: 28935990
[TBL] [Abstract][Full Text] [Related]
19. THE SPECTRUM OF TP53, SF3B1, AND NOTCH1 MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS EXPOSED TO IONIZING RADIATION DUE TO THE CHORNOBYL NPP ACCIDENT.
Bilous NI; Abramenko IV; Chumak AA; Dyagil IS; Martina ZV; Saenko V; Bazyka DA
Probl Radiac Med Radiobiol; 2018 Dec; 23():283-301. PubMed ID: 30582853
[TBL] [Abstract][Full Text] [Related]
20. Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia.
Arruga F; Gizdic B; Serra S; Vaisitti T; Ciardullo C; Coscia M; Laurenti L; D'Arena G; Jaksic O; Inghirami G; Rossi D; Gaidano G; Deaglio S
Leukemia; 2014 May; 28(5):1060-70. PubMed ID: 24170027
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]