BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

390 related articles for article (PubMed ID: 24793877)

  • 1. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways.
    Xiao L; Zhao W; Li HM; Wan DJ; Li DS; Chen T; Tang YJ
    Eur J Med Chem; 2014 Jun; 80():267-77. PubMed ID: 24793877
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
    Zhao W; Chen L; Li HM; Wang DJ; Li DS; Chen T; Yuan ZP; Tang YJ
    Bioorg Med Chem; 2014 Jun; 22(11):2998-3007. PubMed ID: 24775914
    [TBL] [Abstract][Full Text] [Related]  

  • 3. One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents.
    Shankaraiah N; Kumar NP; Amula SB; Nekkanti S; Jeengar MK; Naidu VG; Reddy TS; Kamal A
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4239-44. PubMed ID: 26292628
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives.
    Li WQ; Wang XL; Qian K; Liu YQ; Wang CY; Yang L; Tian J; Morris-Natschke SL; Zhou XW; Lee KH
    Bioorg Med Chem; 2013 Apr; 21(8):2363-2369. PubMed ID: 23490151
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 4β-[4'-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents.
    Kamal A; Suresh P; Ramaiah MJ; Srinivasa Reddy T; Kapavarapu RK; Rao BN; Imthiajali S; Lakshminarayan Reddy T; Pushpavalli SN; Shankaraiah N; Pal-Bhadra M
    Bioorg Med Chem; 2013 Sep; 21(17):5198-208. PubMed ID: 23849207
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and evaluation of novel podophyllotoxin analogs.
    Li J; Hua HM; Tang YB; Zhang S; Ohkoshi E; Lee KH; Xiao Zy
    Bioorg Med Chem Lett; 2012 Jul; 22(13):4293-5. PubMed ID: 22658864
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors.
    Sathish M; Kavitha B; Nayak VL; Tangella Y; Ajitha A; Nekkanti S; Alarifi A; Shankaraiah N; Nagesh N; Kamal A
    Eur J Med Chem; 2018 Jan; 144():557-571. PubMed ID: 29289881
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer.
    Reddy VG; Bonam SR; Reddy TS; Akunuri R; Naidu VGM; Nayak VL; Bhargava SK; Kumar HMS; Srihari P; Kamal A
    Eur J Med Chem; 2018 Jan; 144():595-611. PubMed ID: 29289884
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and evaluation of novel ellipticines as potential anti-cancer agents.
    Deane FM; O'Sullivan EC; Maguire AR; Gilbert J; Sakoff JA; McCluskey A; McCarthy FO
    Org Biomol Chem; 2013 Feb; 11(8):1334-44. PubMed ID: 23314103
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.
    Zhuo ST; Li CY; Hu MH; Chen SB; Yao PF; Huang SL; Ou TM; Tan JH; An LK; Li D; Gu LQ; Huang ZS
    Org Biomol Chem; 2013 Jun; 11(24):3989-4005. PubMed ID: 23657605
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities.
    Kamal A; Kumar BA; Suresh P; Agrawal SK; Chashoo G; Singh SK; Saxena AK
    Bioorg Med Chem; 2010 Dec; 18(24):8493-500. PubMed ID: 21074444
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and pharmacological evaluation of novel bisindolylalkanes analogues.
    Song YL; Dong YF; Yang T; Zhang CC; Su LM; Huang X; Zhang DN; Yang GL; Liu YX
    Bioorg Med Chem; 2013 Dec; 21(24):7624-7. PubMed ID: 24262885
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and cytotoxic activity of novel derivatives of 4'-demethylepipodophyllotoxin.
    Chen SW; Tian X; Tu YQ
    Bioorg Med Chem Lett; 2004 Oct; 14(20):5063-6. PubMed ID: 15380199
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and evaluation of aroylthiourea derivatives of 4-β-amino-4'-O-demethyl-4-desoxypodophyllotoxin as novel topoisomerase II inhibitors.
    Zhao Y; Ge CW; Wu ZH; Wang CN; Fang JH; Zhu L
    Eur J Med Chem; 2011 Mar; 46(3):901-6. PubMed ID: 21277655
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel nalidixic acid derivatives targeting topoisomerase II enzyme; Design, synthesis, anticancer activity and effect on cell cycle profile.
    Khalil OM; Gedawy EM; El-Malah AA; Adly ME
    Bioorg Chem; 2019 Mar; 83():262-276. PubMed ID: 30391699
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors.
    Zhang W; Zhang B; Zhang W; Yang T; Wang N; Gao C; Tan C; Liu H; Jiang Y
    Eur J Med Chem; 2016 Jun; 116():59-70. PubMed ID: 27060757
    [TBL] [Abstract][Full Text] [Related]  

  • 17. N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase.
    Baviskar AT; Madaan C; Preet R; Mohapatra P; Jain V; Agarwal A; Guchhait SK; Kundu CN; Banerjee UC; Bharatam PV
    J Med Chem; 2011 Jul; 54(14):5013-30. PubMed ID: 21644529
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents.
    Chen W; Shen Y; Li Z; Zhang M; Lu C; Shen Y
    Eur J Med Chem; 2014 Oct; 86():782-96. PubMed ID: 25240702
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.
    Yadav AA; Chee GL; Wu X; Patel D; Yalowich JC; Hasinoff BB
    Bioorg Med Chem; 2015 Jul; 23(13):3542-51. PubMed ID: 25922181
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.
    Xiao Z; Bastow KF; Vance JR; Lee KH
    Bioorg Med Chem; 2004 Jun; 12(12):3339-44. PubMed ID: 15158802
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.