BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 24799397)

  • 1. Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.
    Yang K; Brouwer KL
    Drug Metab Dispos; 2014 Jul; 42(7):1219-26. PubMed ID: 24799397
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.
    Lee JK; Marion TL; Abe K; Lim C; Pollock GM; Brouwer KL
    J Pharmacol Exp Ther; 2010 Jan; 332(1):26-34. PubMed ID: 19801447
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.
    Yang K; Pfeifer ND; Hardwick RN; Yue W; Stewart PW; Brouwer KL
    Mol Pharm; 2014 Mar; 11(3):766-75. PubMed ID: 24410402
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.
    Cheng Y; Chen S; Freeden C; Chen W; Zhang Y; Abraham P; Nelson DM; Humphreys WG; Gan J; Lai Y
    J Pharmacol Exp Ther; 2017 Sep; 362(3):385-394. PubMed ID: 28645914
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats.
    Yue W; Lee JK; Abe K; Sugiyama Y; Brouwer KL
    Drug Metab Dispos; 2011 Mar; 39(3):441-7. PubMed ID: 21106720
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.
    Funk C; Ponelle C; Scheuermann G; Pantze M
    Mol Pharmacol; 2001 Mar; 59(3):627-35. PubMed ID: 11179459
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.
    Enokizono J; Kusuhara H; Sugiyama Y
    Drug Metab Dispos; 2007 Feb; 35(2):209-14. PubMed ID: 17093005
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion.
    Yue W; Abe K; Brouwer KL
    Mol Pharm; 2009; 6(1):134-43. PubMed ID: 19105722
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.
    Marion TL; Perry CH; St Claire RL; Yue W; Brouwer KL
    Toxicol Sci; 2011 Apr; 120(2):371-80. PubMed ID: 21262925
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate.
    Funk C; Pantze M; Jehle L; Ponelle C; Scheuermann G; Lazendic M; Gasser R
    Toxicology; 2001 Oct; 167(1):83-98. PubMed ID: 11557132
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury.
    Yang K; Pfeifer ND; Köck K; Brouwer KL
    J Pharmacol Exp Ther; 2015 May; 353(2):415-23. PubMed ID: 25711339
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes.
    Li N; Bi YA; Duignan DB; Lai Y
    Mol Pharm; 2009; 6(4):1180-9. PubMed ID: 19545175
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes.
    Swift B; Yue W; Brouwer KL
    Pharm Res; 2010 Sep; 27(9):1987-98. PubMed ID: 20652625
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
    Tettey JN; Maggs JL; Rapeport WG; Pirmohamed M; Park BK
    Chem Res Toxicol; 2001 Aug; 14(8):965-74. PubMed ID: 11511170
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The effect of troglitazone biliary excretion on metabolite distribution and cholestasis in transporter-deficient rats.
    Kostrubsky VE; Vore M; Kindt E; Burliegh J; Rogers K; Peter G; Altrogge D; Sinz MW
    Drug Metab Dispos; 2001 Dec; 29(12):1561-6. PubMed ID: 11717175
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.
    Tian X; Li J; Zamek-Gliszczynski MJ; Bridges AS; Zhang P; Patel NJ; Raub TJ; Pollack GM; Brouwer KL
    Antimicrob Agents Chemother; 2007 Sep; 51(9):3230-4. PubMed ID: 17576841
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport.
    Wolf KK; Vora S; Webster LO; Generaux GT; Polli JW; Brouwer KL
    Toxicol In Vitro; 2010 Feb; 24(1):297-309. PubMed ID: 19706322
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat.
    Zamek-Gliszczynski MJ; Hoffmaster KA; Humphreys JE; Tian X; Nezasa K; Brouwer KL
    J Pharmacol Exp Ther; 2006 Oct; 319(1):459-67. PubMed ID: 16857726
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.
    Lepist EI; Gillies H; Smith W; Hao J; Hubert C; St Claire RL; Brouwer KR; Ray AS
    PLoS One; 2014; 9(1):e87548. PubMed ID: 24498134
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.
    Zamek-Gliszczynski MJ; Hoffmaster KA; Tian X; Zhao R; Polli JW; Humphreys JE; Webster LO; Bridges AS; Kalvass JC; Brouwer KL
    Drug Metab Dispos; 2005 Aug; 33(8):1158-65. PubMed ID: 15860656
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.