BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 24810902)

  • 1. Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.
    Rotili D; Tarantino D; Marrocco B; Gros C; Masson V; Poughon V; Ausseil F; Chang Y; Labella D; Cosconati S; Di Maro S; Novellino E; Schnekenburger M; Grandjenette C; Bouvy C; Diederich M; Cheng X; Arimondo PB; Mai A
    PLoS One; 2014; 9(5):e96941. PubMed ID: 24810902
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
    Chang Y; Zhang X; Horton JR; Upadhyay AK; Spannhoff A; Liu J; Snyder JP; Bedford MT; Cheng X
    Nat Struct Mol Biol; 2009 Mar; 16(3):312-7. PubMed ID: 19219047
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
    Liu F; Chen X; Allali-Hassani A; Quinn AM; Wigle TJ; Wasney GA; Dong A; Senisterra G; Chau I; Siarheyeva A; Norris JL; Kireev DB; Jadhav A; Herold JM; Janzen WP; Arrowsmith CH; Frye SV; Brown PJ; Simeonov A; Vedadi M; Jin J
    J Med Chem; 2010 Aug; 53(15):5844-57. PubMed ID: 20614940
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening.
    Charles MRC; Mahesh A; Lin SY; Hsieh HP; Dhayalan A; Coumar MS
    Biochimie; 2020 Jan; 168():220-230. PubMed ID: 31756401
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma.
    Ren A; Qiu Y; Cui H; Fu G
    Biochem Biophys Res Commun; 2015 Mar; 459(1):10-7. PubMed ID: 25634693
    [TBL] [Abstract][Full Text] [Related]  

  • 6. G9a inhibition induced PKM2 regulates autophagic responses.
    Ahmad F; Dixit D; Joshi SD; Sen E
    Int J Biochem Cell Biol; 2016 Sep; 78():87-95. PubMed ID: 27417236
    [TBL] [Abstract][Full Text] [Related]  

  • 7. G9a - An Appealing Antineoplastic Target.
    Chen WL; Sun HP; Li DD; Wang ZH; You QD; Guo XK
    Curr Cancer Drug Targets; 2017; 17(6):555-568. PubMed ID: 27174055
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
    Kubicek S; O'Sullivan RJ; August EM; Hickey ER; Zhang Q; Teodoro ML; Rea S; Mechtler K; Kowalski JA; Homon CA; Kelly TA; Jenuwein T
    Mol Cell; 2007 Feb; 25(3):473-81. PubMed ID: 17289593
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells.
    Lu Z; Tian Y; Salwen HR; Chlenski A; Godley LA; Raj JU; Yang Q
    Anticancer Drugs; 2013 Jun; 24(5):484-93. PubMed ID: 23466651
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
    Liu F; Barsyte-Lovejoy D; Li F; Xiong Y; Korboukh V; Huang XP; Allali-Hassani A; Janzen WP; Roth BL; Frye SV; Arrowsmith CH; Brown PJ; Vedadi M; Jin J
    J Med Chem; 2013 Nov; 56(21):8931-42. PubMed ID: 24102134
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.
    Malmquist NA; Moss TA; Mecheri S; Scherf A; Fuchter MJ
    Proc Natl Acad Sci U S A; 2012 Oct; 109(41):16708-13. PubMed ID: 23011794
    [TBL] [Abstract][Full Text] [Related]  

  • 12. BIX-01294, a G9a inhibitor, suppresses cell proliferation by inhibiting autophagic flux in nasopharyngeal carcinoma cells.
    Li Q; Wang L; Ji D; Bao X; Tan G; Liang X; Deng P; Pi H; Lu Y; Chen C; He M; Zhang L; Zhou Z; Yu Z; Deng A
    Invest New Drugs; 2021 Jun; 39(3):686-696. PubMed ID: 33387131
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines.
    Kondengaden SM; Luo LF; Huang K; Zhu M; Zang L; Bataba E; Wang R; Luo C; Wang B; Li KK; Wang PG
    Eur J Med Chem; 2016 Oct; 122():382-393. PubMed ID: 27393948
    [TBL] [Abstract][Full Text] [Related]  

  • 14. IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo.
    Park KE; Johnson CM; Cabot RA
    Reprod Fertil Dev; 2012; 24(6):813-21. PubMed ID: 22781932
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
    Tao H; Li H; Su Y; Feng D; Wang X; Zhang C; Ma H; Hu Q
    Mol Cell Biochem; 2014 Sep; 394(1-2):23-30. PubMed ID: 24833465
    [TBL] [Abstract][Full Text] [Related]  

  • 16. An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases.
    Upadhyay AK; Rotili D; Han JW; Hu R; Chang Y; Labella D; Zhang X; Yoon YS; Mai A; Cheng X
    J Mol Biol; 2012 Feb; 416(3):319-27. PubMed ID: 22227394
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells.
    Wojtala M; Macierzyńska-Piotrowska E; Rybaczek D; Pirola L; Balcerczyk A
    Pharmacol Res; 2018 Feb; 128():252-263. PubMed ID: 29113759
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II).
    Lenstra DC; Al Temimi AHK; Mecinović J
    Bioorg Med Chem Lett; 2018 Apr; 28(7):1234-1238. PubMed ID: 29519735
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Beneficial effects of diazepin-quinazolin-amine derivative (BIX-01294) on preimplantation development and molecular characteristics of cloned mouse embryos.
    Huang Y; Jiang X; Yu M; Huang R; Yao J; Li M; Zheng F; Yang X
    Reprod Fertil Dev; 2017 Jun; 29(6):1260-1269. PubMed ID: 27477633
    [TBL] [Abstract][Full Text] [Related]  

  • 20. BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production.
    Kim Y; Kim YS; Kim DE; Lee JS; Song JH; Kim HG; Cho DH; Jeong SY; Jin DH; Jang SJ; Seol HS; Suh YA; Lee SJ; Kim CS; Koh JY; Hwang JJ
    Autophagy; 2013 Dec; 9(12):2126-39. PubMed ID: 24322755
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.