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2. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Boone MA; Taslim C; Crow JC; Selich-Anderson J; Byrum AK; Showpnil IA; Sunkel BD; Wang M; Stanton BZ; Theisen ER; Lessnick SL Oncogene; 2021 Jul; 40(29):4759-4769. PubMed ID: 34145397 [TBL] [Abstract][Full Text] [Related]
3. EWS-FLI-1 regulates the neuronal repressor gene REST, which controls Ewing sarcoma growth and vascular morphology. Zhou Z; Yu L; Kleinerman ES Cancer; 2014 Feb; 120(4):579-88. PubMed ID: 24415532 [TBL] [Abstract][Full Text] [Related]
4. Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma. Sankar S; Bell R; Stephens B; Zhuo R; Sharma S; Bearss DJ; Lessnick SL Oncogene; 2013 Oct; 32(42):5089-100. PubMed ID: 23178492 [TBL] [Abstract][Full Text] [Related]
5. High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability. He T; Surdez D; Rantala JK; Haapa-Paananen S; Ban J; Kauer M; Tomazou E; Fey V; Alonso J; Kovar H; Delattre O; Iljin K Gene; 2017 Jan; 596():137-146. PubMed ID: 27760381 [TBL] [Abstract][Full Text] [Related]
6. EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma. Showpnil IA; Selich-Anderson J; Taslim C; Boone MA; Crow JC; Theisen ER; Lessnick SL Nucleic Acids Res; 2022 Sep; 50(17):9814-9837. PubMed ID: 36124657 [TBL] [Abstract][Full Text] [Related]
7. The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation. Li X; McGee-Lawrence ME; Decker M; Westendorf JJ J Cell Biochem; 2010 Nov; 111(4):933-43. PubMed ID: 20665663 [TBL] [Abstract][Full Text] [Related]
8. Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model. Takigami I; Ohno T; Kitade Y; Hara A; Nagano A; Kawai G; Saitou M; Matsuhashi A; Yamada K; Shimizu K Int J Cancer; 2011 Jan; 128(1):216-26. PubMed ID: 20648560 [TBL] [Abstract][Full Text] [Related]
9. EWS-FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma. Shimizu R; Tanaka M; Tsutsumi S; Aburatani H; Yamazaki Y; Homme M; Kitagawa Y; Nakamura T Cancer Sci; 2018 Sep; 109(9):2907-2918. PubMed ID: 29945296 [TBL] [Abstract][Full Text] [Related]
11. Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma. Wang S; Huo X; Yang Y; Mo Y; Kollipara RK; Kittler R Cancer Lett; 2023 Jan; 552():215984. PubMed ID: 36330954 [TBL] [Abstract][Full Text] [Related]
14. FOXM1 is an oncogenic mediator in Ewing Sarcoma. Christensen L; Joo J; Lee S; Wai D; Triche TJ; May WA PLoS One; 2013; 8(1):e54556. PubMed ID: 23365673 [TBL] [Abstract][Full Text] [Related]
15. Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue. Gierisch ME; Pfistner F; Lopez-Garcia LA; Harder L; Schäfer BW; Niggli FK J Biol Chem; 2016 Dec; 291(52):26922-26933. PubMed ID: 27875302 [TBL] [Abstract][Full Text] [Related]
16. Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription. Patel M; Simon JM; Iglesia MD; Wu SB; McFadden AW; Lieb JD; Davis IJ Genome Res; 2012 Feb; 22(2):259-70. PubMed ID: 22086061 [TBL] [Abstract][Full Text] [Related]
17. EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma. Tanner JM; Bensard C; Wei P; Krah NM; Schell JC; Gardiner J; Schiffman J; Lessnick SL; Rutter J Mol Cancer Res; 2017 Nov; 15(11):1517-1530. PubMed ID: 28720588 [TBL] [Abstract][Full Text] [Related]
18. Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis. Showpnil IA; Miller KR; Taslim C; Pishas KI; Lessnick SL; Theisen ER J Vis Exp; 2020 Jun; (160):. PubMed ID: 32658189 [TBL] [Abstract][Full Text] [Related]
19. EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Gorthi A; Romero JC; Loranc E; Cao L; Lawrence LA; Goodale E; Iniguez AB; Bernard X; Masamsetti VP; Roston S; Lawlor ER; Toretsky JA; Stegmaier K; Lessnick SL; Chen Y; Bishop AJR Nature; 2018 Mar; 555(7696):387-391. PubMed ID: 29513652 [TBL] [Abstract][Full Text] [Related]