These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
491 related articles for article (PubMed ID: 24819116)
1. Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. Johnson TW; Richardson PF; Bailey S; Brooun A; Burke BJ; Collins MR; Cui JJ; Deal JG; Deng YL; Dinh D; Engstrom LD; He M; Hoffman J; Hoffman RL; Huang Q; Kania RS; Kath JC; Lam H; Lam JL; Le PT; Lingardo L; Liu W; McTigue M; Palmer CL; Sach NW; Smeal T; Smith GL; Stewart AE; Timofeevski S; Zhu H; Zhu J; Zou HY; Edwards MP J Med Chem; 2014 Jun; 57(11):4720-44. PubMed ID: 24819116 [TBL] [Abstract][Full Text] [Related]
2. Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of anaplastic lymphoma kinase and c-Ros oncogene 1. Yamazaki S; Lam JL; Zou HY; Wang H; Smeal T; Vicini P J Pharmacol Exp Ther; 2014 Oct; 351(1):67-76. PubMed ID: 25073473 [TBL] [Abstract][Full Text] [Related]
3. Mechanistic understanding of translational pharmacokinetic-pharmacodynamic relationships in nonclinical tumor models: a case study of orally available novel inhibitors of anaplastic lymphoma kinase. Yamazaki S; Lam JL; Zou HY; Wang H; Smeal T; Vicini P Drug Metab Dispos; 2015 Jan; 43(1):54-62. PubMed ID: 25349124 [TBL] [Abstract][Full Text] [Related]
4. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. Zou HY; Li Q; Engstrom LD; West M; Appleman V; Wong KA; McTigue M; Deng YL; Liu W; Brooun A; Timofeevski S; McDonnell SR; Jiang P; Falk MD; Lappin PB; Affolter T; Nichols T; Hu W; Lam J; Johnson TW; Smeal T; Charest A; Fantin VR Proc Natl Acad Sci U S A; 2015 Mar; 112(11):3493-8. PubMed ID: 25733882 [TBL] [Abstract][Full Text] [Related]
5. Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R. Wang Y; Chen S; Hu G; Wang J; Gou W; Zuo D; Gu Y; Gong P; Zhai X Eur J Med Chem; 2018 Jan; 143():123-136. PubMed ID: 29174809 [TBL] [Abstract][Full Text] [Related]
6. First macrocyclic 3 Basit S; Ashraf Z; Lee K; Latif M Eur J Med Chem; 2017 Jul; 134():348-356. PubMed ID: 28431340 [TBL] [Abstract][Full Text] [Related]
7. Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor. Menichincheri M; Ardini E; Magnaghi P; Avanzi N; Banfi P; Bossi R; Buffa L; Canevari G; Ceriani L; Colombo M; Corti L; Donati D; Fasolini M; Felder E; Fiorelli C; Fiorentini F; Galvani A; Isacchi A; Borgia AL; Marchionni C; Nesi M; Orrenius C; Panzeri A; Pesenti E; Rusconi L; Saccardo MB; Vanotti E; Perrone E; Orsini P J Med Chem; 2016 Apr; 59(7):3392-408. PubMed ID: 27003761 [TBL] [Abstract][Full Text] [Related]
8. PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models. Zou HY; Friboulet L; Kodack DP; Engstrom LD; Li Q; West M; Tang RW; Wang H; Tsaparikos K; Wang J; Timofeevski S; Katayama R; Dinh DM; Lam H; Lam JL; Yamazaki S; Hu W; Patel B; Bezwada D; Frias RL; Lifshits E; Mahmood S; Gainor JF; Affolter T; Lappin PB; Gukasyan H; Lee N; Deng S; Jain RK; Johnson TW; Shaw AT; Fantin VR; Smeal T Cancer Cell; 2015 Jul; 28(1):70-81. PubMed ID: 26144315 [TBL] [Abstract][Full Text] [Related]
9. Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors. Davare MA; Vellore NA; Wagner JP; Eide CA; Goodman JR; Drilon A; Deininger MW; O'Hare T; Druker BJ Proc Natl Acad Sci U S A; 2015 Sep; 112(39):E5381-90. PubMed ID: 26372962 [TBL] [Abstract][Full Text] [Related]
10. NPM/ALK mutants resistant to ASP3026 display variable sensitivity to alternative ALK inhibitors but succumb to the novel compound PF-06463922. Mologni L; Ceccon M; Pirola A; Chiriano G; Piazza R; Scapozza L; Gambacorti-Passerini C Oncotarget; 2015 Mar; 6(8):5720-34. PubMed ID: 25749034 [TBL] [Abstract][Full Text] [Related]
11. Design, synthesis and biological evaluations of 2-amino-4-(1-piperidine) pyridine derivatives as novel anti crizotinib-resistant ALK/ROS1 dual inhibitors. Liu S; Jiang Y; Yan R; Li Z; Wan S; Zhang T; Wu X; Hou J; Zhu Z; Tian Y; Zhang J Eur J Med Chem; 2019 Oct; 179():358-375. PubMed ID: 31260890 [TBL] [Abstract][Full Text] [Related]
12. Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. Huang Q; Johnson TW; Bailey S; Brooun A; Bunker KD; Burke BJ; Collins MR; Cook AS; Cui JJ; Dack KN; Deal JG; Deng YL; Dinh D; Engstrom LD; He M; Hoffman J; Hoffman RL; Johnson PS; Kania RS; Lam H; Lam JL; Le PT; Li Q; Lingardo L; Liu W; Lu MW; McTigue M; Palmer CL; Richardson PF; Sach NW; Shen H; Smeal T; Smith GL; Stewart AE; Timofeevski S; Tsaparikos K; Wang H; Zhu H; Zhu J; Zou HY; Edwards MP J Med Chem; 2014 Feb; 57(4):1170-87. PubMed ID: 24432909 [TBL] [Abstract][Full Text] [Related]
13. Investigation on the binding mechanism of loratinib with the c-ros oncogene 1 (ROS1) receptor tyrosine kinase via molecular dynamics simulation and binding free energy calculations. Wu X; Wang Y; Wan S; Zhang J J Biomol Struct Dyn; 2018 Sep; 36(12):3106-3113. PubMed ID: 28893136 [TBL] [Abstract][Full Text] [Related]
15. The preclinical profile of crizotinib for the treatment of non-small-cell lung cancer and other neoplastic disorders. Roskoski R Expert Opin Drug Discov; 2013 Sep; 8(9):1165-79. PubMed ID: 23805942 [TBL] [Abstract][Full Text] [Related]
16. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Guo M; Zuo D; Zhang J; Xing L; Gou W; Jiang F; Jiang N; Zhang D; Zhai X Eur J Med Chem; 2018 Oct; 158():322-333. PubMed ID: 30223120 [TBL] [Abstract][Full Text] [Related]
17. The ALK/ROS1 Inhibitor PF-06463922 Overcomes Primary Resistance to Crizotinib in ALK-Driven Neuroblastoma. Infarinato NR; Park JH; Krytska K; Ryles HT; Sano R; Szigety KM; Li Y; Zou HY; Lee NV; Smeal T; Lemmon MA; Mossé YP Cancer Discov; 2016 Jan; 6(1):96-107. PubMed ID: 26554404 [TBL] [Abstract][Full Text] [Related]
18. The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN. Guan J; Tucker ER; Wan H; Chand D; Danielson LS; Ruuth K; El Wakil A; Witek B; Jamin Y; Umapathy G; Robinson SP; Johnson TW; Smeal T; Martinsson T; Chesler L; Palmer RH; Hallberg B Dis Model Mech; 2016 Sep; 9(9):941-52. PubMed ID: 27483357 [TBL] [Abstract][Full Text] [Related]
19. ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway. Ou SH; Tan J; Yen Y; Soo RA Expert Rev Anticancer Ther; 2012 Apr; 12(4):447-56. PubMed ID: 22500682 [TBL] [Abstract][Full Text] [Related]
20. An interaction map of small-molecule kinase inhibitors with anaplastic lymphoma kinase (ALK) mutants in ALK-positive non-small cell lung cancer. Ai X; Shen S; Shen L; Lu S Biochimie; 2015 May; 112():111-20. PubMed ID: 25769414 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]