BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 24819406)

  • 1. Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors.
    Dohle W; Leese MP; Jourdan FL; Chapman CJ; Hamel E; Ferrandis E; Potter BV
    ChemMedChem; 2014 Aug; 9(8):1783-93. PubMed ID: 24819406
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolines.
    Dohle W; Leese MP; Jourdan FL; Major MR; Bai R; Hamel E; Ferrandis E; Kasprzyk PG; Fiore A; Newman SP; Purohit A; Potter BV
    ChemMedChem; 2014 Feb; 9(2):350-70. PubMed ID: 24436228
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors.
    Leese MP; Jourdan FL; Major MR; Dohle W; Hamel E; Ferrandis E; Fiore A; Kasprzyk PG; Potter BV
    ChemMedChem; 2014 Jan; 9(1):85-108, 1. PubMed ID: 24124095
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.
    Dohle W; Prota AE; Menchon G; Hamel E; Steinmetz MO; Potter BVL
    ACS Omega; 2019 Jan; 4(1):755-764. PubMed ID: 30775645
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.
    Romagnoli R; Kimatrai Salvador M; Schiaffino Ortega S; Baraldi PG; Oliva P; Baraldi S; Lopez-Cara LC; Brancale A; Ferla S; Hamel E; Balzarini J; Liekens S; Mattiuzzo E; Basso G; Viola G
    Eur J Med Chem; 2018 Jan; 143():683-698. PubMed ID: 29220790
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.
    Dohle W; Jourdan FL; Menchon G; Prota AE; Foster PA; Mannion P; Hamel E; Thomas MP; Kasprzyk PG; Ferrandis E; Steinmetz MO; Leese MP; Potter BVL
    J Med Chem; 2018 Feb; 61(3):1031-1044. PubMed ID: 29227648
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biology-oriented synthesis of a tetrahydroisoquinoline-based compound collection targeting microtubule polymerization.
    Zimmermann TJ; Roy S; Martinez NE; Ziegler S; Hedberg C; Waldmann H
    Chembiochem; 2013 Feb; 14(3):295-300. PubMed ID: 23364933
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization.
    Prota AE; Danel F; Bachmann F; Bargsten K; Buey RM; Pohlmann J; Reinelt S; Lane H; Steinmetz MO
    J Mol Biol; 2014 Apr; 426(8):1848-60. PubMed ID: 24530796
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate.
    Zhu P; Ye W; Li J; Zhang Y; Huang W; Cheng M; Wang Y; Zhang Y; Liu H; Zuo J
    Chem Biol Drug Des; 2017 Mar; 89(3):443-455. PubMed ID: 27717183
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of 1-phenyl-1,2,3,4-dihydroisoquinoline compounds as tubulin polymerization inhibitors.
    Zheng CH; Chen J; Liu J; Zhou XT; Liu N; Shi D; Huang JJ; Lv JG; Zhu J; Zhou YJ
    Arch Pharm (Weinheim); 2012 Jun; 345(6):454-62. PubMed ID: 22415658
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones.
    Leese MP; Jourdan FL; Major MR; Dohle W; Thomas MP; Hamel E; Ferrandis E; Mahon MF; Newman SP; Purohit A; Potter BV
    ChemMedChem; 2014 Apr; 9(4):798-812. PubMed ID: 24596315
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors.
    Sardaru MC; Craciun AM; Al Matarneh CM; Sandu IA; Amarandi RM; Popovici L; Ciobanu CI; Peptanariu D; Pinteala M; Mangalagiu II; Danac R
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):1581-1595. PubMed ID: 32752898
    [TBL] [Abstract][Full Text] [Related]  

  • 13. β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells.
    Malebari AM; Fayne D; Nathwani SM; O'Connell F; Noorani S; Twamley B; O'Boyle NM; O'Sullivan J; Zisterer DM; Meegan MJ
    Eur J Med Chem; 2020 Mar; 189():112050. PubMed ID: 31954879
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antiproliferative benzothiazoles incorporating a trimethoxyphenyl scaffold as novel colchicine site tubulin polymerisation inhibitors.
    Fu DJ; Liu SM; Li FH; Yang JJ; Li J
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):1050-1059. PubMed ID: 32299262
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents.
    Stefański T; Mikstacka R; Kurczab R; Dutkiewicz Z; Kucińska M; Murias M; Zielińska-Przyjemska M; Cichocki M; Teubert A; Kaczmarek M; Hogendorf A; Sobiak S
    Eur J Med Chem; 2018 Jan; 144():797-816. PubMed ID: 29291446
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
    Ibrahim TS; Hawwas MM; Malebari AM; Taher ES; Omar AM; Neamatallah T; Abdel-Samii ZK; Safo MK; Elshaier YAMM
    J Enzyme Inhib Med Chem; 2021 Dec; 36(1):802-818. PubMed ID: 33730937
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors.
    Wang G; Fan M; Liu W; He M; Li Y; Peng Z
    J Enzyme Inhib Med Chem; 2021 Dec; 36(1):1402-1410. PubMed ID: 34157927
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation.
    Liu W; He Y; Guo Z; Wang M; Han X; Jia H; He J; Miao S; Wang S
    J Enzyme Inhib Med Chem; 2023 Dec; 38(1):2155815. PubMed ID: 36629423
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 4- and 5-aroylindoles as novel classes of potent antitubulin agents.
    Liou JP; Wu CY; Hsieh HP; Chang CY; Chen CM; Kuo CC; Chang JY
    J Med Chem; 2007 Sep; 50(18):4548-52. PubMed ID: 17685504
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Thiazolidinone Constraint Combretastatin Analogs as Novel Antitubulin Agents: Design, Synthesis, Biological Evaluation and Docking Studies.
    Sharma S; Gupta MK; Saxena AK; Bedi PM
    Anticancer Agents Med Chem; 2017; 17(2):230-240. PubMed ID: 27141882
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.