BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

233 related articles for article (PubMed ID: 24840303)

  • 1. Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs.
    Himmel DM; Myshakina NS; Ilina T; Van Ry A; Ho WC; Parniak MA; Arnold E
    J Mol Biol; 2014 Jul; 426(14):2617-31. PubMed ID: 24840303
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.
    Wang L; Sarafianos SG; Wang Z
    Acc Chem Res; 2020 Jan; 53(1):218-230. PubMed ID: 31880912
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase.
    Boyer PL; Smith SJ; Zhao XZ; Das K; Gruber K; Arnold E; Burke TR; Hughes SH
    J Virol; 2018 Jul; 92(13):. PubMed ID: 29643235
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular Docking and Molecular Dynamics Simulation Based Approach to Explore the Dual Inhibitor Against HIV-1 Reverse Transcriptase and Integrase.
    Chander S; Pandey RK; Penta A; Choudhary BS; Sharma M; Malik R; Prajapati VK; Murugesan S
    Comb Chem High Throughput Screen; 2017; 20(8):734-746. PubMed ID: 28641512
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.
    Tang J; Vernekar SKV; Chen YL; Miller L; Huber AD; Myshakina N; Sarafianos SG; Parniak MA; Wang Z
    Eur J Med Chem; 2017 Jun; 133():85-96. PubMed ID: 28384548
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.
    Cuzzucoli Crucitti G; Métifiot M; Pescatori L; Messore A; Madia VN; Pupo G; Saccoliti F; Scipione L; Tortorella S; Esposito F; Corona A; Cadeddu M; Marchand C; Pommier Y; Tramontano E; Costi R; Di Santo R
    J Med Chem; 2015 Feb; 58(4):1915-28. PubMed ID: 25629256
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 1,2,4-Triazolo[1,5-
    Desantis J; Massari S; Corona A; Astolfi A; Sabatini S; Manfroni G; Palazzotti D; Cecchetti V; Pannecouque C; Tramontano E; Tabarrini O
    Molecules; 2020 Mar; 25(5):. PubMed ID: 32151066
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6.
    Corona A; Meleddu R; Esposito F; Distinto S; Bianco G; Masaoka T; Maccioni E; Menéndez-Arias L; Alcaro S; Le Grice SF; Tramontano E
    PLoS One; 2016; 11(1):e0147225. PubMed ID: 26800261
    [TBL] [Abstract][Full Text] [Related]  

  • 9. HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
    Himmel DM; Sarafianos SG; Dharmasena S; Hossain MM; McCoy-Simandle K; Ilina T; Clark AD; Knight JL; Julias JG; Clark PK; Krogh-Jespersen K; Levy RM; Hughes SH; Parniak MA; Arnold E
    ACS Chem Biol; 2006 Dec; 1(11):702-12. PubMed ID: 17184135
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.
    Shaw-Reid CA; Feuston B; Munshi V; Getty K; Krueger J; Hazuda DJ; Parniak MA; Miller MD; Lewis D
    Biochemistry; 2005 Feb; 44(5):1595-606. PubMed ID: 15683243
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
    Kankanala J; Kirby KA; Huber AD; Casey MC; Wilson DJ; Sarafianos SG; Wang Z
    Eur J Med Chem; 2017 Dec; 141():149-161. PubMed ID: 29031062
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase.
    Yanagita H; Urano E; Matsumoto K; Ichikawa R; Takaesu Y; Ogata M; Murakami T; Wu H; Chiba J; Komano J; Hoshino T
    Bioorg Med Chem; 2011 Jan; 19(2):816-25. PubMed ID: 21193314
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones.
    Arion D; Sluis-Cremer N; Min KL; Abram ME; Fletcher RS; Parniak MA
    J Biol Chem; 2002 Jan; 277(2):1370-4. PubMed ID: 11684697
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions.
    Corona A; Onnis V; Deplano A; Bianco G; Demurtas M; Distinto S; Cheng YC; Alcaro S; Esposito F; Tramontano E
    Pathog Dis; 2017 Aug; 75(6):. PubMed ID: 28859311
    [TBL] [Abstract][Full Text] [Related]  

  • 15. (3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase.
    Meleddu R; Distinto S; Corona A; Bianco G; Cannas V; Esposito F; Artese A; Alcaro S; Matyus P; Bogdan D; Cottiglia F; Tramontano E; Maccioni E
    Eur J Med Chem; 2015 Mar; 93():452-60. PubMed ID: 25728026
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
    Himmel DM; Maegley KA; Pauly TA; Bauman JD; Das K; Dharia C; Clark AD; Ryan K; Hickey MJ; Love RA; Hughes SH; Bergqvist S; Arnold E
    Structure; 2009 Dec; 17(12):1625-1635. PubMed ID: 20004166
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase.
    Kirby KA; Myshakina NA; Christen MT; Chen YL; Schmidt HA; Huber AD; Xi Z; Kim S; Rao RK; Kramer ST; Yang Q; Singh K; Parniak MA; Wang Z; Ishima R; Sarafianos SG
    Antimicrob Agents Chemother; 2017 Oct; 61(10):. PubMed ID: 28760905
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases.
    Esposito F; Kharlamova T; Distinto S; Zinzula L; Cheng YC; Dutschman G; Floris G; Markt P; Corona A; Tramontano E
    FEBS J; 2011 May; 278(9):1444-57. PubMed ID: 21348941
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase.
    Meleddu R; Cannas V; Distinto S; Sarais G; Del Vecchio C; Esposito F; Bianco G; Corona A; Cottiglia F; Alcaro S; Parolin C; Artese A; Scalise D; Fresta M; Arridu A; Ortuso F; Maccioni E; Tramontano E
    ChemMedChem; 2014 Aug; 9(8):1869-79. PubMed ID: 24850787
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Combinatorial selection, inhibition, and antiviral activity of DNA thioaptamers targeting the RNase H domain of HIV-1 reverse transcriptase.
    Somasunderam A; Ferguson MR; Rojo DR; Thiviyanathan V; Li X; O'Brien WA; Gorenstein DG
    Biochemistry; 2005 Aug; 44(30):10388-95. PubMed ID: 16042416
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.