BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 24849925)

  • 1. Effect of LX4211 on glucose homeostasis and body composition in preclinical models.
    Powell DR; DaCosta CM; Smith M; Doree D; Harris A; Buhring L; Heydorn W; Nouraldeen A; Xiong W; Yalamanchili P; Mseeh F; Wilson A; Shadoan M; Zambrowicz B; Ding ZM
    J Pharmacol Exp Ther; 2014 Aug; 350(2):232-42. PubMed ID: 24849925
    [TBL] [Abstract][Full Text] [Related]  

  • 2. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose.
    Powell DR; Smith M; Greer J; Harris A; Zhao S; DaCosta C; Mseeh F; Shadoan MK; Sands A; Zambrowicz B; Ding ZM
    J Pharmacol Exp Ther; 2013 May; 345(2):250-9. PubMed ID: 23487174
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effects of LX4211, a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects.
    Zambrowicz B; Ogbaa I; Frazier K; Banks P; Turnage A; Freiman J; Boehm KA; Ruff D; Powell D; Sands A
    Clin Ther; 2013 Aug; 35(8):1162-1173.e8. PubMed ID: 23911260
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of LX4211, a dual SGLT1/SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes.
    Zambrowicz B; Ding ZM; Ogbaa I; Frazier K; Banks P; Turnage A; Freiman J; Smith M; Ruff D; Sands A; Powell D
    Clin Ther; 2013 Mar; 35(3):273-285.e7. PubMed ID: 23433601
    [TBL] [Abstract][Full Text] [Related]  

  • 5. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial.
    Zambrowicz B; Freiman J; Brown PM; Frazier KS; Turnage A; Bronner J; Ruff D; Shadoan M; Banks P; Mseeh F; Rawlins DB; Goodwin NC; Mabon R; Harrison BA; Wilson A; Sands A; Powell DR
    Clin Pharmacol Ther; 2012 Aug; 92(2):158-69. PubMed ID: 22739142
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Improved glycemic control in mice lacking Sglt1 and Sglt2.
    Powell DR; DaCosta CM; Gay J; Ding ZM; Smith M; Greer J; Doree D; Jeter-Jones S; Mseeh F; Rodriguez LA; Harris A; Buhring L; Platt KA; Vogel P; Brommage R; Shadoan MK; Sands AT; Zambrowicz B
    Am J Physiol Endocrinol Metab; 2013 Jan; 304(2):E117-30. PubMed ID: 23149623
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor.
    Lapuerta P; Zambrowicz B; Strumph P; Sands A
    Diab Vasc Dis Res; 2015 Mar; 12(2):101-10. PubMed ID: 25690134
    [TBL] [Abstract][Full Text] [Related]  

  • 8. LX4211 therapy reduces postprandial glucose levels in patients with type 2 diabetes mellitus and renal impairment despite low urinary glucose excretion.
    Zambrowicz B; Lapuerta P; Strumph P; Banks P; Wilson A; Ogbaa I; Sands A; Powell D
    Clin Ther; 2015 Jan; 37(1):71-82.e12. PubMed ID: 25529979
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Intestinal Sodium Glucose Cotransporter 1 Inhibition Enhances Glucagon-Like Peptide-1 Secretion in Normal and Diabetic Rodents.
    Oguma T; Nakayama K; Kuriyama C; Matsushita Y; Yoshida K; Hikida K; Obokata N; Tsuda-Tsukimoto M; Saito A; Arakawa K; Ueta K; Shiotani M
    J Pharmacol Exp Ther; 2015 Sep; 354(3):279-89. PubMed ID: 26105952
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus.
    Song P; Onishi A; Koepsell H; Vallon V
    Expert Opin Ther Targets; 2016 Sep; 20(9):1109-25. PubMed ID: 26998950
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy.
    Rosenstock J; Cefalu WT; Lapuerta P; Zambrowicz B; Ogbaa I; Banks P; Sands A
    Diabetes Care; 2015 Mar; 38(3):431-8. PubMed ID: 25216510
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Sotagliflozin as a potential treatment for type 2 diabetes mellitus.
    Cariou B; Charbonnel B
    Expert Opin Investig Drugs; 2015; 24(12):1647-56. PubMed ID: 26548423
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors.
    Xu G; Du F; Kuo GH; Xu JZ; Liang Y; Demarest K; Gaul MD
    Bioorg Med Chem Lett; 2020 Sep; 30(17):127387. PubMed ID: 32738984
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Combined SGLT1 and SGLT2 Inhibitors and Their Role in Diabetes Care.
    Danne T; Biester T; Kordonouri O
    Diabetes Technol Ther; 2018 Jun; 20(S2):S269-S277. PubMed ID: 29916741
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Study design and rationale of a dose-ranging trial of LX4211, a dual inhibitor of SGLT1 and SGLT2, in type 2 diabetes inadequately controlled on metformin monotherapy.
    Lapuerta P; Rosenstock J; Zambrowicz B; Powell DR; Ogbaa I; Freiman J; Cefalu WT; Banks P; Frazier K; Kelly M; Sands A
    Clin Cardiol; 2013 Jul; 36(7):367-71. PubMed ID: 23630033
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents.
    Du F; Hinke SA; Cavanaugh C; Polidori D; Wallace N; Kirchner T; Jennis M; Lang W; Kuo GH; Gaul MD; Lenhard J; Demarest K; Ajami NJ; Liang Y; Hornby PJ
    J Pharmacol Exp Ther; 2018 Jun; 365(3):676-687. PubMed ID: 29674332
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats.
    Nagata T; Fukazawa M; Honda K; Yata T; Kawai M; Yamane M; Murao N; Yamaguchi K; Kato M; Mitsui T; Suzuki Y; Ikeda S; Kawabe Y
    Am J Physiol Endocrinol Metab; 2013 Feb; 304(4):E414-23. PubMed ID: 23249697
    [TBL] [Abstract][Full Text] [Related]  

  • 18. TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity.
    Yamamoto K; Uchida S; Kitano K; Fukuhara N; Okumura-Kitajima L; Gunji E; Kozakai A; Tomoike H; Kojima N; Asami J; Toyoda H; Arai M; Takahashi T; Takahashi K
    Br J Pharmacol; 2011 Sep; 164(1):181-91. PubMed ID: 21410690
    [TBL] [Abstract][Full Text] [Related]  

  • 19. LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2.
    Powell DR; Smith MG; Doree DD; Harris AL; Xiong WW; Mseeh F; Wilson A; Gopinathan S; Diaz D; Goodwin NC; Harrison B; Strobel E; Rawlins DB; Carson K; Zambrowicz B; Ding ZM
    Pharmacol Res Perspect; 2015 Mar; 3(2):e00129. PubMed ID: 26038705
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level.
    Katsuno K; Fujimori Y; Takemura Y; Hiratochi M; Itoh F; Komatsu Y; Fujikura H; Isaji M
    J Pharmacol Exp Ther; 2007 Jan; 320(1):323-30. PubMed ID: 17050778
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.