BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 24856614)

  • 21. Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004.
    Huynh T; Valant C; Crosby IT; Sexton PM; Christopoulos A; Capuano B
    ACS Chem Neurosci; 2015 Jun; 6(6):838-44. PubMed ID: 25857219
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor.
    Avlani VA; Langmead CJ; Guida E; Wood MD; Tehan BG; Herdon HJ; Watson JM; Sexton PM; Christopoulos A
    Mol Pharmacol; 2010 Jul; 78(1):94-104. PubMed ID: 20413650
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy.
    Wakeham MCL; Davie BJ; Chalmers DK; Christopoulos A; Capuano B; Valant C; Scammells PJ
    ACS Chem Neurosci; 2022 Jan; 13(1):97-111. PubMed ID: 34905693
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Bitopic Binding Mode of an M
    Bradley SJ; Molloy C; Bundgaard C; Mogg AJ; Thompson KJ; Dwomoh L; Sanger HE; Crabtree MD; Brooke SM; Sexton PM; Felder CC; Christopoulos A; Broad LM; Tobin AB; Langmead CJ
    Mol Pharmacol; 2018 Jun; 93(6):645-656. PubMed ID: 29695609
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites.
    Schober DA; Croy CH; Xiao H; Christopoulos A; Felder CC
    Mol Pharmacol; 2014 Jul; 86(1):116-23. PubMed ID: 24807966
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects.
    Valant C; Felder CC; Sexton PM; Christopoulos A
    Mol Pharmacol; 2012 Jan; 81(1):41-52. PubMed ID: 21989256
    [TBL] [Abstract][Full Text] [Related]  

  • 27. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).
    Nawaratne V; Leach K; Suratman N; Loiacono RE; Felder CC; Armbruster BN; Roth BL; Sexton PM; Christopoulos A
    Mol Pharmacol; 2008 Oct; 74(4):1119-31. PubMed ID: 18628403
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice.
    Gould RW; Dencker D; Grannan M; Bubser M; Zhan X; Wess J; Xiang Z; Locuson C; Lindsley CW; Conn PJ; Jones CK
    ACS Chem Neurosci; 2015 Oct; 6(10):1683-95. PubMed ID: 26176846
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Dronedarone Modulates M1 and M3 Muscarinic Receptors with Subtype Selectivity, Functional Selectivity, and Probe Dependence.
    Jayasuriya GM; Elmslie G; Burstein ES; Ellis J
    Pharmacology; 2017; 99(3-4):128-138. PubMed ID: 27992867
    [TBL] [Abstract][Full Text] [Related]  

  • 30. The pharmacologic characterization of allosteric molecules: Gq protein activation.
    Bdioui S; Verdi J; Pierre N; Trinquet E; Roux T; Kenakin T
    J Recept Signal Transduct Res; 2019 Apr; 39(2):106-113. PubMed ID: 31322035
    [No Abstract]   [Full Text] [Related]  

  • 31. SAR studies on carboxylic acid series M(1) selective positive allosteric modulators (PAMs).
    Kuduk SD; Beshore DC
    Curr Top Med Chem; 2014; 14(15):1738-54. PubMed ID: 25176125
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Allosteric modulation of a chemogenetically modified G protein-coupled receptor.
    Abdul-Ridha A; Lane JR; Sexton PM; Canals M; Christopoulos A
    Mol Pharmacol; 2013 Feb; 83(2):521-30. PubMed ID: 23197649
    [TBL] [Abstract][Full Text] [Related]  

  • 33. An Approach to Discovering Novel Muscarinic M
    Kurimoto E; Matsuda S; Shimizu Y; Sako Y; Mandai T; Sugimoto T; Sakamoto H; Kimura H
    J Pharmacol Exp Ther; 2018 Jan; 364(1):28-37. PubMed ID: 29025977
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1.
    Langmead CJ; Austin NE; Branch CL; Brown JT; Buchanan KA; Davies CH; Forbes IT; Fry VA; Hagan JJ; Herdon HJ; Jones GA; Jeggo R; Kew JN; Mazzali A; Melarange R; Patel N; Pardoe J; Randall AD; Roberts C; Roopun A; Starr KR; Teriakidis A; Wood MD; Whittington M; Wu Z; Watson J
    Br J Pharmacol; 2008 Jul; 154(5):1104-15. PubMed ID: 18454168
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor.
    Suratman S; Leach K; Sexton P; Felder C; Loiacono R; Christopoulos A
    Br J Pharmacol; 2011 Apr; 162(7):1659-70. PubMed ID: 21198541
    [TBL] [Abstract][Full Text] [Related]  

  • 36. THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner.
    Steinfeld T; Hughes AD; Klein U; Smith JA; Mammen M
    Mol Pharmacol; 2011 Mar; 79(3):389-99. PubMed ID: 21139051
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Investigation of the interaction of a putative allosteric modulator, N-(2,3-diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) methanamine hydrobromide (SCH-202676), with M1 muscarinic acetylcholine receptors.
    Lanzafame A; Christopoulos A
    J Pharmacol Exp Ther; 2004 Mar; 308(3):830-7. PubMed ID: 14617684
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Rational design of partial agonists for the muscarinic m1 acetylcholine receptor.
    Chen X; Klöckner J; Holze J; Zimmermann C; Seemann WK; Schrage R; Bock A; Mohr K; Tränkle C; Holzgrabe U; Decker M
    J Med Chem; 2015 Jan; 58(2):560-76. PubMed ID: 25478907
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.
    Kuduk SD; Chang RK; Di Marco CN; Pitts DR; Greshock TJ; Ma L; Wittmann M; Seager MA; Koeplinger KA; Thompson CD; Hartman GD; Bilodeau MT; Ray WJ
    J Med Chem; 2011 Jul; 54(13):4773-80. PubMed ID: 21682298
    [TBL] [Abstract][Full Text] [Related]  

  • 40. FRET Studies of Quinolone-Based Bitopic Ligands and Their Structural Analogues at the Muscarinic M
    Messerer R; Kauk M; Volpato D; Alonso Canizal MC; Klöckner J; Zabel U; Nuber S; Hoffmann C; Holzgrabe U
    ACS Chem Biol; 2017 Mar; 12(3):833-843. PubMed ID: 28117571
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.