350 related articles for article (PubMed ID: 24889603)
1. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Hunter JC; Gurbani D; Ficarro SB; Carrasco MA; Lim SM; Choi HG; Xie T; Marto JA; Chen Z; Gray NS; Westover KD
Proc Natl Acad Sci U S A; 2014 Jun; 111(24):8895-900. PubMed ID: 24889603
[TBL] [Abstract][Full Text] [Related]
2. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.
Lim SM; Westover KD; Ficarro SB; Harrison RA; Choi HG; Pacold ME; Carrasco M; Hunter J; Kim ND; Xie T; Sim T; Jänne PA; Meyerson M; Marto JA; Engen JR; Gray NS
Angew Chem Int Ed Engl; 2014 Jan; 53(1):199-204. PubMed ID: 24259466
[TBL] [Abstract][Full Text] [Related]
3. Mutant-Specific Targeting of Ras G12C Activity by Covalently Reacting Small Molecules.
Goody RS; Müller MP; Rauh D
Cell Chem Biol; 2019 Oct; 26(10):1338-1348. PubMed ID: 31378709
[TBL] [Abstract][Full Text] [Related]
4. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Ostrem JM; Peters U; Sos ML; Wells JA; Shokat KM
Nature; 2013 Nov; 503(7477):548-51. PubMed ID: 24256730
[TBL] [Abstract][Full Text] [Related]
5.
Pálfy G; Vida I; Perczel A
Biomol NMR Assign; 2020 Apr; 14(1):1-7. PubMed ID: 31468366
[TBL] [Abstract][Full Text] [Related]
6. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Gentile DR; Rathinaswamy MK; Jenkins ML; Moss SM; Siempelkamp BD; Renslo AR; Burke JE; Shokat KM
Cell Chem Biol; 2017 Dec; 24(12):1455-1466.e14. PubMed ID: 29033317
[TBL] [Abstract][Full Text] [Related]
7. Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model.
Zhang B; Zhang Y; Shacter E; Zheng Y
Biochemistry; 2005 Feb; 44(7):2566-76. PubMed ID: 15709769
[TBL] [Abstract][Full Text] [Related]
8. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
Lu S; Banerjee A; Jang H; Zhang J; Gaponenko V; Nussinov R
J Biol Chem; 2015 Nov; 290(48):28887-900. PubMed ID: 26453300
[TBL] [Abstract][Full Text] [Related]
9. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Scheffzek K; Ahmadian MR; Kabsch W; Wiesmüller L; Lautwein A; Schmitz F; Wittinghofer A
Science; 1997 Jul; 277(5324):333-8. PubMed ID: 9219684
[TBL] [Abstract][Full Text] [Related]
10. G proteins, effectors and GAPs: structure and mechanism.
Sprang SR
Curr Opin Struct Biol; 1997 Dec; 7(6):849-56. PubMed ID: 9434906
[TBL] [Abstract][Full Text] [Related]
11. The structural basis for the transition from Ras-GTP to Ras-GDP.
Hall BE; Bar-Sagi D; Nassar N
Proc Natl Acad Sci U S A; 2002 Sep; 99(19):12138-42. PubMed ID: 12213964
[TBL] [Abstract][Full Text] [Related]
12. Inhibition of RAS: proven and potential vulnerabilities.
Zuberi M; Khan I; O'Bryan JP
Biochem Soc Trans; 2020 Oct; 48(5):1831-1841. PubMed ID: 32869838
[TBL] [Abstract][Full Text] [Related]
13. Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap.
Nicely NI; Kosak J; de Serrano V; Mattos C
Structure; 2004 Nov; 12(11):2025-36. PubMed ID: 15530367
[TBL] [Abstract][Full Text] [Related]
14. Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
Ihara K; Muraguchi S; Kato M; Shimizu T; Shirakawa M; Kuroda S; Kaibuchi K; Hakoshima T
J Biol Chem; 1998 Apr; 273(16):9656-66. PubMed ID: 9545299
[TBL] [Abstract][Full Text] [Related]
15. Structural basis for the unique biological function of small GTPase RHEB.
Yu Y; Li S; Xu X; Li Y; Guan K; Arnold E; Ding J
J Biol Chem; 2005 Apr; 280(17):17093-100. PubMed ID: 15728574
[TBL] [Abstract][Full Text] [Related]
16. What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
Filchtinski D; Sharabi O; Rüppel A; Vetter IR; Herrmann C; Shifman JM
J Mol Biol; 2010 Jun; 399(3):422-35. PubMed ID: 20361980
[TBL] [Abstract][Full Text] [Related]
17. Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.
Ye M; Shima F; Muraoka S; Liao J; Okamoto H; Yamamoto M; Tamura A; Yagi N; Ueki T; Kataoka T
J Biol Chem; 2005 Sep; 280(35):31267-75. PubMed ID: 15994326
[TBL] [Abstract][Full Text] [Related]
18. Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
Xiong Y; Lu J; Hunter J; Li L; Scott D; Choi HG; Lim SM; Manandhar A; Gondi S; Sim T; Westover KD; Gray NS
ACS Med Chem Lett; 2017 Jan; 8(1):61-66. PubMed ID: 28105276
[TBL] [Abstract][Full Text] [Related]
19. DRoP: a water analysis program identifies Ras-GTP-specific pathway of communication between membrane-interacting regions and the active site.
Kearney BM; Johnson CW; Roberts DM; Swartz P; Mattos C
J Mol Biol; 2014 Feb; 426(3):611-29. PubMed ID: 24189050
[TBL] [Abstract][Full Text] [Related]
20. 2'-Deoxy Guanosine Nucleotides Alter the Biochemical Properties of Ras.
Yun SD; Scott E; Moghadamchargari Z; Laganowsky A
Biochemistry; 2023 Aug; 62(16):2450-2460. PubMed ID: 37487239
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]