BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

313 related articles for article (PubMed ID: 24891519)

  • 1. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.
    Chhabra S; Chang SC; Nguyen HM; Huq R; Tanner MR; Londono LM; Estrada R; Dhawan V; Chauhan S; Upadhyay SK; Gindin M; Hotez PJ; Valenzuela JG; Mohanty B; Swarbrick JD; Wulff H; Iadonato SP; Gutman GA; Beeton C; Pennington MW; Norton RS; Chandy KG
    FASEB J; 2014 Sep; 28(9):3952-64. PubMed ID: 24891519
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases.
    Beeton C; Pennington MW; Norton RS
    Inflamm Allergy Drug Targets; 2011 Oct; 10(5):313-21. PubMed ID: 21824083
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.
    Beeton C; Pennington MW; Wulff H; Singh S; Nugent D; Crossley G; Khaytin I; Calabresi PA; Chen CY; Gutman GA; Chandy KG
    Mol Pharmacol; 2005 Apr; 67(4):1369-81. PubMed ID: 15665253
    [TBL] [Abstract][Full Text] [Related]  

  • 4. N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.
    Chang SC; Huq R; Chhabra S; Beeton C; Pennington MW; Smith BJ; Norton RS
    FEBS J; 2015 Jun; 282(12):2247-59. PubMed ID: 25864722
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.
    Matheu MP; Beeton C; Garcia A; Chi V; Rangaraju S; Safrina O; Monaghan K; Uemura MI; Li D; Pal S; de la Maza LM; Monuki E; Flügel A; Pennington MW; Parker I; Chandy KG; Cahalan MD
    Immunity; 2008 Oct; 29(4):602-14. PubMed ID: 18835197
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin.
    Pennington MW; Lanigan MD; Kalman K; Mahnir VM; Rauer H; McVaugh CT; Behm D; Donaldson D; Chandy KG; Kem WR; Norton RS
    Biochemistry; 1999 Nov; 38(44):14549-58. PubMed ID: 10545177
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.
    Beeton C; Smith BJ; Sabo JK; Crossley G; Nugent D; Khaytin I; Chi V; Chandy KG; Pennington MW; Norton RS
    J Biol Chem; 2008 Jan; 283(2):988-97. PubMed ID: 17984097
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes.
    Pennington MW; Beeton C; Galea CA; Smith BJ; Chi V; Monaghan KP; Garcia A; Rangaraju S; Giuffrida A; Plank D; Crossley G; Nugent D; Khaytin I; Lefievre Y; Peshenko I; Dixon C; Chauhan S; Orzel A; Inoue T; Hu X; Moore RV; Norton RS; Chandy KG
    Mol Pharmacol; 2009 Apr; 75(4):762-73. PubMed ID: 19122005
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.
    Tanner MR; Tajhya RB; Huq R; Gehrmann EJ; Rodarte KE; Atik MA; Norton RS; Pennington MW; Beeton C
    Clin Immunol; 2017 Jul; 180():45-57. PubMed ID: 28389388
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma.
    Koshy S; Huq R; Tanner MR; Atik MA; Porter PC; Khan FS; Pennington MW; Hanania NA; Corry DB; Beeton C
    J Biol Chem; 2014 May; 289(18):12623-32. PubMed ID: 24644290
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases.
    Norton RS; Pennington MW; Wulff H
    Curr Med Chem; 2004 Dec; 11(23):3041-52. PubMed ID: 15578998
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.
    Tarcha EJ; Chi V; Muñoz-Elías EJ; Bailey D; Londono LM; Upadhyay SK; Norton K; Banks A; Tjong I; Nguyen H; Hu X; Ruppert GW; Boley SE; Slauter R; Sams J; Knapp B; Kentala D; Hansen Z; Pennington MW; Beeton C; Chandy KG; Iadonato SP
    J Pharmacol Exp Ther; 2012 Sep; 342(3):642-53. PubMed ID: 22637724
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin.
    Rauer H; Pennington M; Cahalan M; Chandy KG
    J Biol Chem; 1999 Jul; 274(31):21885-92. PubMed ID: 10419508
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases.
    Ye F; Hu Y; Yu W; Xie Z; Hu J; Cao Z; Li W; Wu Y
    Toxins (Basel); 2016 Apr; 8(4):115. PubMed ID: 27104568
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis.
    Beeton C; Wulff H; Barbaria J; Clot-Faybesse O; Pennington M; Bernard D; Cahalan MD; Chandy KG; Béraud E
    Proc Natl Acad Sci U S A; 2001 Nov; 98(24):13942-7. PubMed ID: 11717451
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor.
    Harvey AJ; Gable RW; Baell JB
    Bioorg Med Chem Lett; 2005 Jul; 15(13):3193-6. PubMed ID: 15935664
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Conformational exchange in the potassium channel blocker ShK.
    Iwakawa N; Baxter NJ; Wai DCC; Fowler NJ; Morales RAV; Sugase K; Norton RS; Williamson MP
    Sci Rep; 2019 Dec; 9(1):19307. PubMed ID: 31848433
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.
    Schmitz A; Sankaranarayanan A; Azam P; Schmidt-Lassen K; Homerick D; Hänsel W; Wulff H
    Mol Pharmacol; 2005 Nov; 68(5):1254-70. PubMed ID: 16099841
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Designed peptide analogues of the potassium channel blocker ShK toxin.
    Lanigan MD; Pennington MW; Lefievre Y; Rauer H; Norton RS
    Biochemistry; 2001 Dec; 40(51):15528-37. PubMed ID: 11747428
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.
    Beeton C; Wulff H; Singh S; Botsko S; Crossley G; Gutman GA; Cahalan MD; Pennington M; Chandy KG
    J Biol Chem; 2003 Mar; 278(11):9928-37. PubMed ID: 12511563
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.