These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 24900280)

  • 41. Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y(12) antagonists for inhibition of platelet aggregation.
    Caroff E; Meyer E; Treiber A; Hilpert K; Riederer MA
    Bioorg Med Chem Lett; 2014 Sep; 24(17):4323-31. PubMed ID: 25113932
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists.
    Xia M; Hou C; DeMong D; Pollack S; Pan M; Singer M; Matheis M; Murray W; Cavender D; Wachter M
    Bioorg Med Chem Lett; 2008 Dec; 18(24):6468-70. PubMed ID: 18990568
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5.
    Ogilvie P; Bardi G; Clark-Lewis I; Baggiolini M; Uguccioni M
    Blood; 2001 Apr; 97(7):1920-4. PubMed ID: 11264152
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2).
    Strunz AK; Zweemer AJ; Weiss C; Schepmann D; Junker A; Heitman LH; Koch M; Wünsch B
    Bioorg Med Chem; 2015 Jul; 23(14):4034-49. PubMed ID: 25766632
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile.
    Hughes RO; Rogier DJ; Devraj R; Zheng C; Cao G; Feng H; Xia M; Anand R; Xing L; Glenn J; Zhang K; Covington M; Morton PA; Hutzler JM; Davis JW; Scherle P; Baribaud F; Bahinski A; Mo ZL; Newton R; Metcalf B; Xue CB
    Bioorg Med Chem Lett; 2011 May; 21(9):2626-30. PubMed ID: 21315584
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Structure prediction and molecular dynamics simulations of a G-protein coupled receptor: human CCR2 receptor.
    Singh R; Sobhia ME
    J Biomol Struct Dyn; 2013; 31(7):694-715. PubMed ID: 22909007
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle.
    Mirzadegan T; Diehl F; Ebi B; Bhakta S; Polsky I; McCarley D; Mulkins M; Weatherhead GS; Lapierre JM; Dankwardt J; Morgans D; Wilhelm R; Jarnagin K
    J Biol Chem; 2000 Aug; 275(33):25562-71. PubMed ID: 10770925
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Isolation and structures of novel fungal metabolites as chemokine receptor (CCR2) antagonists.
    Herath KB; Jayasuriya H; Ondeyka JG; Polishook JD; Bills GF; Dombrowski AW; Cabello A; Vicario PP; Zweerink H; Guan Z; Singh SB
    J Antibiot (Tokyo); 2005 Nov; 58(11):686-94. PubMed ID: 16466022
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.
    Zheng Y; Qin L; Zacarías NV; de Vries H; Han GW; Gustavsson M; Dabros M; Zhao C; Cherney RJ; Carter P; Stamos D; Abagyan R; Cherezov V; Stevens RC; IJzerman AP; Heitman LH; Tebben A; Kufareva I; Handel TM
    Nature; 2016 Dec; 540(7633):458-461. PubMed ID: 27926736
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
    Barlaam B; Cadogan E; Campbell A; Colclough N; Dishington A; Durant S; Goldberg K; Hassall LA; Hughes GD; MacFaul PA; McGuire TM; Pass M; Patel A; Pearson S; Petersen J; Pike KG; Robb G; Stratton N; Xin G; Zhai B
    ACS Med Chem Lett; 2018 Aug; 9(8):809-814. PubMed ID: 30128072
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
    Scott JS; Moss TA; Balazs A; Barlaam B; Breed J; Carbajo RJ; Chiarparin E; Davey PRJ; Delpuech O; Fawell S; Fisher DI; Gagrica S; Gangl ET; Grebe T; Greenwood RD; Hande S; Hatoum-Mokdad H; Herlihy K; Hughes S; Hunt TA; Huynh H; Janbon SLM; Johnson T; Kavanagh S; Klinowska T; Lawson M; Lister AS; Marden S; McGinnity DF; Morrow CJ; Nissink JWM; O'Donovan DH; Peng B; Polanski R; Stead DS; Stokes S; Thakur K; Throner SR; Tucker MJ; Varnes J; Wang H; Wilson DM; Wu D; Wu Y; Yang B; Yang W
    J Med Chem; 2020 Dec; 63(23):14530-14559. PubMed ID: 32910656
    [TBL] [Abstract][Full Text] [Related]  

  • 52. In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist.
    af Forselles KJ; Root J; Clarke T; Davey D; Aughton K; Dack K; Pullen N
    Br J Pharmacol; 2011 Dec; 164(7):1847-56. PubMed ID: 21595651
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication.
    Skerlj R; Bridger G; Zhou Y; Bourque E; McEachern E; Danthi S; Langille J; Harwig C; Veale D; Carpenter B; Ba T; Bey M; Baird I; Wilson T; Metz M; MacFarland R; Mosi R; Bodart V; Wong R; Fricker S; Huskens D; Schols D
    ACS Med Chem Lett; 2012 Mar; 3(3):216-21. PubMed ID: 24900457
    [TBL] [Abstract][Full Text] [Related]  

  • 54. 4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.
    Butora G; Morriello GJ; Kothandaraman S; Guiadeen D; Pasternak A; Parsons WH; MacCoss M; Vicario PP; Cascieri MA; Yang L
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4715-22. PubMed ID: 16870431
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.
    Moree WJ; Kataoka K; Ramirez-Weinhouse MM; Shiota T; Imai M; Tsutsumi T; Sudo M; Endo N; Muroga Y; Hada T; Fanning D; Saunders J; Kato Y; Myers PL; Tarby CM
    Bioorg Med Chem Lett; 2008 Mar; 18(6):1869-73. PubMed ID: 18313297
    [TBL] [Abstract][Full Text] [Related]  

  • 56. CCR2 antagonists.
    Struthers M; Pasternak A
    Curr Top Med Chem; 2010; 10(13):1278-98. PubMed ID: 20536421
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Identification of the first potent, selective and bioavailable PPARα antagonist.
    Bravo Y; Baccei CS; Broadhead A; Bundey R; Chen A; Clark R; Correa L; Jacintho JD; Lorrain DS; Messmer D; Stebbins K; Prasit P; Stock N
    Bioorg Med Chem Lett; 2014 May; 24(10):2267-72. PubMed ID: 24745969
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability.
    Johnson PS; Ryckmans T; Bryans J; Beal DM; Dack KN; Feeder N; Harrison A; Lewis M; Mason HJ; Mills J; Newman J; Pasquinet C; Rawson DJ; Roberts LR; Russell R; Spark D; Stobie A; Underwood TJ; Ward R; Wheeler S
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5684-7. PubMed ID: 21885275
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity.
    Kawai M; Nakamura H; Sakurada I; Shimokawa H; Tanaka H; Matsumizu M; Ando K; Hattori K; Ohta A; Nukui S; Omura A; Kawamura M
    Bioorg Med Chem Lett; 2007 Oct; 17(20):5533-6. PubMed ID: 17768047
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.
    Brown AR; Bosies M; Cameron H; Clark J; Cowley A; Craighead M; Elmore MA; Firth A; Goodwin R; Goutcher S; Grant E; Grassie M; Grove SJ; Hamilton NM; Hampson H; Hillier A; Ho KK; Kiczun M; Kingsbury C; Kultgen SG; Littlewood PT; Lusher SJ; Macdonald S; McIntosh L; McIntyre T; Mistry A; Morphy JR; Nimz O; Ohlmeyer M; Pick J; Rankovic Z; Sherborne B; Smith A; Speake M; Spinks G; Thomson F; Watson L; Weston M
    Bioorg Med Chem Lett; 2011 Jan; 21(1):137-40. PubMed ID: 21129964
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.