These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 24900289)

  • 1. Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.
    Ghisaidoobe A; Bikker P; de Bruijn AC; Godschalk FD; Rogaar E; Guijt MC; Hagens P; Halma JM; Van't Hart SM; Luitjens SB; van Rixel VH; Wijzenbroek M; Zweegers T; Donker-Koopman WE; Strijland A; Boot R; van der Marel G; Overkleeft HS; Aerts JM; van den Berg RJ
    ACS Med Chem Lett; 2011 Feb; 2(2):119-23. PubMed ID: 24900289
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.
    Ghisaidoobe AT; van den Berg RJ; Butt SS; Strijland A; Donker-Koopman WE; Scheij S; van den Nieuwendijk AM; Koomen GJ; van Loevezijn A; Leemhuis M; Wennekes T; van der Stelt M; van der Marel GA; van Boeckel CA; Aerts JM; Overkleeft HS
    J Med Chem; 2014 Nov; 57(21):9096-104. PubMed ID: 25250725
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors.
    van den Berg RJ; van Rijssel ER; Ferraz MJ; Houben J; Strijland A; Donker-Koopman WE; Wennekes T; Bonger KM; Ghisaidoobe AB; Hoogendoorn S; van der Marel GA; Codée JD; Overkleeft HS; Aerts JM
    ChemMedChem; 2015 Dec; 10(12):2042-62. PubMed ID: 26492941
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.
    Lahav D; Liu B; van den Berg RJBHN; van den Nieuwendijk AMCH; Wennekes T; Ghisaidoobe AT; Breen I; Ferraz MJ; Kuo CL; Wu L; Geurink PP; Ovaa H; van der Marel GA; van der Stelt M; Boot RG; Davies GJ; Aerts JMFG; Overkleeft HS
    J Am Chem Soc; 2017 Oct; 139(40):14192-14197. PubMed ID: 28937220
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish.
    Lelieveld LT; Mirzaian M; Kuo CL; Artola M; Ferraz MJ; Peter REA; Akiyama H; Greimel P; van den Berg RJBHN; Overkleeft HS; Boot RG; Meijer AH; Aerts JMFG
    J Lipid Res; 2019 Nov; 60(11):1851-1867. PubMed ID: 31562193
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.
    van den Berg RJ; Wennekes T; Ghisaidoobe A; Donker-Koopman WE; Strijland A; Boot RG; van der Marel GA; Aerts JM; Overkleeft HS
    ACS Med Chem Lett; 2011 Jul; 2(7):519-22. PubMed ID: 24900342
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease.
    Yildiz Y; Hoffmann P; Vom Dahl S; Breiden B; Sandhoff R; Niederau C; Horwitz M; Karlsson S; Filocamo M; Elstein D; Beck M; Sandhoff K; Mengel E; Gonzalez MC; Nöthen MM; Sidransky E; Zimran A; Mattheisen M
    Orphanet J Rare Dis; 2013 Sep; 8():151. PubMed ID: 24070122
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Beta-glucosidase 1 (GBA1) is a second bile acid β-glucosidase in addition to β-glucosidase 2 (GBA2). Study in β-glucosidase deficient mice and humans.
    Harzer K; Blech-Hermoni Y; Goldin E; Felderhoff-Mueser U; Igney C; Sidransky E; Yildiz Y
    Biochem Biophys Res Commun; 2012 Jun; 423(2):308-12. PubMed ID: 22659419
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes.
    Burke DG; Rahim AA; Waddington SN; Karlsson S; Enquist I; Bhatia K; Mehta A; Vellodi A; Heales S
    J Inherit Metab Dis; 2013 Sep; 36(5):869-72. PubMed ID: 23151684
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann-Pick C mice.
    Nietupski JB; Pacheco JJ; Chuang WL; Maratea K; Li L; Foley J; Ashe KM; Cooper CG; Aerts JM; Copeland DP; Scheule RK; Cheng SH; Marshall J
    Mol Genet Metab; 2012 Apr; 105(4):621-8. PubMed ID: 22366055
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Assay of β-glucosidase 2 (GBA2) activity using lithocholic acid β-3-O-glucoside substrate for cultured fibroblasts and glucosylceramide for brain tissue.
    Harzer K; Yildiz Y; Beck-Wödl S
    Biol Chem; 2019 May; 400(6):745-752. PubMed ID: 30864417
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals.
    Rugen MD; Vernet MMJL; Hantouti L; Soenens A; Andriotis VME; Rejzek M; Brett P; van den Berg RJBHN; Aerts JMFG; Overkleeft HS; Field RA
    Sci Rep; 2018 Nov; 8(1):16421. PubMed ID: 30401902
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ubiquitous transgene expression of the glucosylceramide-synthesizing enzyme accelerates glucosylceramide accumulation and storage cells in a Gaucher disease mouse model.
    Barnes S; Xu YH; Zhang W; Liou B; Setchell KD; Bao L; Grabowski GA; Sun Y
    PLoS One; 2014; 9(12):e116023. PubMed ID: 25551612
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.
    Schonauer S; Körschen HG; Penno A; Rennhack A; Breiden B; Sandhoff K; Gutbrod K; Dörmann P; Raju DN; Haberkant P; Gerl MJ; Brügger B; Zigdon H; Vardi A; Futerman AH; Thiele C; Wachten D
    J Biol Chem; 2017 Apr; 292(15):6177-6189. PubMed ID: 28258214
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-Activity Studies of N-Butyl-1-deoxynojirimycin (NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2.
    Gu X; Gupta V; Yang Y; Zhu JY; Carlson EJ; Kingsley C; Tash JS; Schönbrunn E; Hawkinson J; Georg GI
    ChemMedChem; 2017 Dec; 12(23):1977-1984. PubMed ID: 28975712
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.
    Ashe KM; Bangari D; Li L; Cabrera-Salazar MA; Bercury SD; Nietupski JB; Cooper CG; Aerts JM; Lee ER; Copeland DP; Cheng SH; Scheule RK; Marshall J
    PLoS One; 2011; 6(6):e21758. PubMed ID: 21738789
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors.
    Baudoin-Dehoux C; Castellan T; Rodriguez F; Rives A; Stauffert F; Garcia V; Levade T; Compain P; Génisson Y
    Molecules; 2019 Jan; 24(2):. PubMed ID: 30669468
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The non-lysosomal β-glucosidase GBA2 is a non-integral membrane-associated protein at the endoplasmic reticulum (ER) and Golgi.
    Körschen HG; Yildiz Y; Raju DN; Schonauer S; Bönigk W; Jansen V; Kremmer E; Kaupp UB; Wachten D
    J Biol Chem; 2013 Feb; 288(5):3381-93. PubMed ID: 23250757
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Glucosylceramide mimics: highly potent GCase inhibitors and selective pharmacological chaperones for mutations associated with types 1 and 2 Gaucher disease.
    Schönemann W; Gallienne E; Ikeda-Obatake K; Asano N; Nakagawa S; Kato A; Adachi I; Górecki M; Frelek J; Martin OR
    ChemMedChem; 2013 Nov; 8(11):1805-17. PubMed ID: 24115322
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.
    Wennekes T; van den Berg RJ; Donker W; van der Marel GA; Strijland A; Aerts JM; Overkleeft HS
    J Org Chem; 2007 Feb; 72(4):1088-97. PubMed ID: 17243712
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.