155 related articles for article (PubMed ID: 24900881)
1. Kinesin spindle protein inhibitors with diaryl amine scaffolds: crystal packing analysis for improved aqueous solubility.
Takeuchi T; Oishi S; Kaneda M; Ohno H; Nakamura S; Nakanishi I; Yamane M; Sawada J; Asai A; Fujii N
ACS Med Chem Lett; 2014 May; 5(5):566-71. PubMed ID: 24900881
[TBL] [Abstract][Full Text] [Related]
2. Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.
Takeuchi T; Oishi S; Kaneda M; Misu R; Ohno H; Sawada J; Asai A; Nakamura S; Nakanishi I; Fujii N
Bioorg Med Chem; 2014 Jun; 22(12):3171-9. PubMed ID: 24794744
[TBL] [Abstract][Full Text] [Related]
3. Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
Cox CD; Torrent M; Breslin MJ; Mariano BJ; Whitman DB; Coleman PJ; Buser CA; Walsh ES; Hamilton K; Schaber MD; Lobell RB; Tao W; South VJ; Kohl NE; Yan Y; Kuo LC; Prueksaritanont T; Slaughter DE; Li C; Mahan E; Lu B; Hartman GD
Bioorg Med Chem Lett; 2006 Jun; 16(12):3175-9. PubMed ID: 16603356
[TBL] [Abstract][Full Text] [Related]
4. Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Fraley ME; Garbaccio RM; Arrington KL; Hoffman WF; Tasber ES; Coleman PJ; Buser CA; Walsh ES; Hamilton K; Fernandes C; Schaber MD; Lobell RB; Tao W; South VJ; Yan Y; Kuo LC; Prueksaritanont T; Shu C; Torrent M; Heimbrook DC; Kohl NE; Huber HE; Hartman GD
Bioorg Med Chem Lett; 2006 Apr; 16(7):1775-9. PubMed ID: 16439123
[TBL] [Abstract][Full Text] [Related]
5. Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.
Cox CD; Breslin MJ; Whitman DB; Coleman PJ; Garbaccio RM; Fraley ME; Zrada MM; Buser CA; Walsh ES; Hamilton K; Lobell RB; Tao W; Abrams MT; South VJ; Huber HE; Kohl NE; Hartman GD
Bioorg Med Chem Lett; 2007 May; 17(10):2697-702. PubMed ID: 17395460
[TBL] [Abstract][Full Text] [Related]
6. Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Coleman PJ; Schreier JD; Cox CD; Fraley ME; Garbaccio RM; Buser CA; Walsh ES; Hamilton K; Lobell RB; Rickert K; Tao W; Diehl RE; South VJ; Davide JP; Kohl NE; Yan Y; Kuo L; Prueksaritanont T; Li C; Mahan EA; Fernandez-Metzler C; Salata JJ; Hartman GD
Bioorg Med Chem Lett; 2007 Oct; 17(19):5390-5. PubMed ID: 17761419
[TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.
Takeuchi T; Oishi S; Watanabe T; Ohno H; Sawada J; Matsuno K; Asai A; Asada N; Kitaura K; Fujii N
J Med Chem; 2011 Jul; 54(13):4839-46. PubMed ID: 21599002
[TBL] [Abstract][Full Text] [Related]
8. Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Garbaccio RM; Fraley ME; Tasber ES; Olson CM; Hoffman WF; Arrington KL; Torrent M; Buser CA; Walsh ES; Hamilton K; Schaber MD; Fernandes C; Lobell RB; Tao W; South VJ; Yan Y; Kuo LC; Prueksaritanont T; Slaughter DE; Shu C; Heimbrook DC; Kohl NE; Huber HE; Hartman GD
Bioorg Med Chem Lett; 2006 Apr; 16(7):1780-3. PubMed ID: 16439122
[TBL] [Abstract][Full Text] [Related]
9. Ligand- and structure-based in silico studies to identify kinesin spindle protein (KSP) inhibitors as potential anticancer agents.
Balakumar C; Ramesh M; Tham CL; Khathi SP; Kozielski F; Srinivasulu C; Hampannavar GA; Sayyad N; Soliman ME; Karpoormath R
J Biomol Struct Dyn; 2018 Nov; 36(14):3687-3704. PubMed ID: 29064326
[TBL] [Abstract][Full Text] [Related]
10. Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
Rickert KW; Schaber M; Torrent M; Neilson LA; Tasber ES; Garbaccio R; Coleman PJ; Harvey D; Zhang Y; Yang Y; Marshall G; Lee L; Walsh ES; Hamilton K; Buser CA
Arch Biochem Biophys; 2008 Jan; 469(2):220-31. PubMed ID: 17999913
[TBL] [Abstract][Full Text] [Related]
11. Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.
Cox CD; Breslin MJ; Mariano BJ; Coleman PJ; Buser CA; Walsh ES; Hamilton K; Huber HE; Kohl NE; Torrent M; Yan Y; Kuo LC; Hartman GD
Bioorg Med Chem Lett; 2005 Apr; 15(8):2041-5. PubMed ID: 15808464
[TBL] [Abstract][Full Text] [Related]
12. ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
Luo L; Parrish CA; Nevins N; McNulty DE; Chaudhari AM; Carson JD; Sudakin V; Shaw AN; Lehr R; Zhao H; Sweitzer S; Lad L; Wood KW; Sakowicz R; Annan RS; Huang PS; Jackson JR; Dhanak D; Copeland RA; Auger KR
Nat Chem Biol; 2007 Nov; 3(11):722-6. PubMed ID: 17922005
[TBL] [Abstract][Full Text] [Related]
13. Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Roecker AJ; Coleman PJ; Mercer SP; Schreier JD; Buser CA; Walsh ES; Hamilton K; Lobell RB; Tao W; Diehl RE; South VJ; Davide JP; Kohl NE; Yan Y; Kuo LC; Li C; Fernandez-Metzler C; Mahan EA; Prueksaritanont T; Hartman GD
Bioorg Med Chem Lett; 2007 Oct; 17(20):5677-82. PubMed ID: 17766111
[TBL] [Abstract][Full Text] [Related]
14. Kinesin spindle protein inhibitors in cancer: a patent review (2008 - present).
Jiang C; You Q
Expert Opin Ther Pat; 2013 Dec; 23(12):1547-60. PubMed ID: 23978071
[TBL] [Abstract][Full Text] [Related]
15. Novel ATP-competitive kinesin spindle protein inhibitors.
Parrish CA; Adams ND; Auger KR; Burgess JL; Carson JD; Chaudhari AM; Copeland RA; Diamond MA; Donatelli CA; Duffy KJ; Faucette LF; Finer JT; Huffman WF; Hugger ED; Jackson JR; Knight SD; Luo L; Moore ML; Newlander KA; Ridgers LH; Sakowicz R; Shaw AN; Sung CM; Sutton D; Wood KW; Zhang SY; Zimmerman MN; Dhanak D
J Med Chem; 2007 Oct; 50(20):4939-52. PubMed ID: 17725339
[TBL] [Abstract][Full Text] [Related]
16. Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.
Dong JJ; Li QS; Liu ZP; Wang SF; Zhao MY; Yang YH; Wang XM; Zhu HL
Eur J Med Chem; 2013; 70():427-33. PubMed ID: 24184776
[TBL] [Abstract][Full Text] [Related]
17. Recent progress in the identification and clinical evaluation of inhibitors of the mitotic kinesin KSP.
Knight SD; Parrish CA
Curr Top Med Chem; 2008; 8(10):888-904. PubMed ID: 18673173
[TBL] [Abstract][Full Text] [Related]
18. Developments of kinesin spindle protein inhibitors as antitumor agents based on the five-membered heterocycle scaffolds.
Zhao GD; Wan RZ; Liu ZP
Curr Med Chem; 2014; 21(23):2691-701. PubMed ID: 24606497
[TBL] [Abstract][Full Text] [Related]
19. Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.
Ogo N; Ishikawa Y; Sawada J; Matsuno K; Hashimoto A; Asai A
ACS Med Chem Lett; 2015 Sep; 6(9):1004-9. PubMed ID: 26396688
[TBL] [Abstract][Full Text] [Related]
20. Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein.
Muthuraja P; Himesh M; Prakash S; Venkatasubramanian U; Manisankar P
Eur J Med Chem; 2018 Mar; 148():106-115. PubMed ID: 29454915
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]