BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

443 related articles for article (PubMed ID: 24922508)

  • 1. Computational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.
    Blacklock K; Verkhivker GM
    PLoS Comput Biol; 2014 Jun; 10(6):e1003679. PubMed ID: 24922508
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Allosteric regulation of the Hsp90 dynamics and stability by client recruiter cochaperones: protein structure network modeling.
    Blacklock K; Verkhivker GM
    PLoS One; 2014; 9(1):e86547. PubMed ID: 24466147
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Exploring Mechanisms of Allosteric Regulation and Communication Switching in the Multiprotein Regulatory Complexes of the Hsp90 Chaperone with Cochaperones and Client Proteins: Atomistic Insights from Integrative Biophysical Modeling and Network Analysis of Conformational Landscapes.
    Verkhivker GM
    J Mol Biol; 2022 Sep; 434(17):167506. PubMed ID: 35202628
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dynamics-based community analysis and perturbation response scanning of allosteric interaction networks in the TRAP1 chaperone structures dissect molecular linkage between conformational asymmetry and sequential ATP hydrolysis.
    Verkhivker GM
    Biochim Biophys Acta Proteins Proteom; 2018 Aug; 1866(8):899-912. PubMed ID: 29684503
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.
    Dixit A; Verkhivker GM
    PLoS One; 2012; 7(5):e37605. PubMed ID: 22624053
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Differential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.
    Blacklock K; Verkhivker GM
    PLoS One; 2013; 8(8):e71936. PubMed ID: 23977182
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90.
    Rehn A; Moroni E; Zierer BK; Tippel F; Morra G; John C; Richter K; Colombo G; Buchner J
    J Mol Biol; 2016 Nov; 428(22):4559-4571. PubMed ID: 27663270
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.
    Stetz G; Tse A; Verkhivker GM
    PLoS One; 2017; 12(11):e0186089. PubMed ID: 29095844
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Allosteric Mechanism of the Hsp90 Chaperone Interactions with Cochaperones and Client Proteins by Modulating Communication Spines of Coupled Regulatory Switches: Integrative Atomistic Modeling of Hsp90 Signaling in Dynamic Interaction Networks.
    Astl L; Stetz G; Verkhivker GM
    J Chem Inf Model; 2020 Jul; 60(7):3616-3631. PubMed ID: 32519853
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Experimentally guided structural modeling and dynamics analysis of Hsp90-p53 interactions: allosteric regulation of the Hsp90 chaperone by a client protein.
    Blacklock K; Verkhivker GM
    J Chem Inf Model; 2013 Nov; 53(11):2962-78. PubMed ID: 24191708
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional Role and Hierarchy of the Intermolecular Interactions in Binding of Protein Kinase Clients to the Hsp90-Cdc37 Chaperone: Structure-Based Network Modeling of Allosteric Regulation.
    Stetz G; Verkhivker GM
    J Chem Inf Model; 2018 Feb; 58(2):405-421. PubMed ID: 29432007
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dissecting Molecular Principles of the Hsp90 Chaperone Regulation by Allosteric Modulators Using a Hierarchical Simulation Approach and Network Modeling of Allosteric Interactions: Conformational Selection Dictates the Diversity of Protein Responses and Ligand-Specific Functional Mechanisms.
    Astl L; Stetz G; Verkhivker GM
    J Chem Theory Comput; 2020 Oct; 16(10):6656-6677. PubMed ID: 32941034
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins.
    Stetz G; Verkhivker GM
    PLoS One; 2015; 10(11):e0143752. PubMed ID: 26619280
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains.
    Czemeres J; Buse K; Verkhivker GM
    PLoS One; 2017; 12(12):e0190267. PubMed ID: 29267381
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Exploring Mechanisms of Communication Switching in the Hsp90-Cdc37 Regulatory Complexes with Client Kinases through Allosteric Coupling of Phosphorylation Sites: Perturbation-Based Modeling and Hierarchical Community Analysis of Residue Interaction Networks.
    Stetz G; Astl L; Verkhivker GM
    J Chem Theory Comput; 2020 Jul; 16(7):4706-4725. PubMed ID: 32492340
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication.
    Stetz G; Verkhivker GM
    PLoS Comput Biol; 2017 Jan; 13(1):e1005299. PubMed ID: 28095400
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure and mechanism of the Hsp90 molecular chaperone machinery.
    Pearl LH; Prodromou C
    Annu Rev Biochem; 2006; 75():271-94. PubMed ID: 16756493
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?
    LaPointe P; Mercier R; Wolmarans A
    Biol Chem; 2020 Mar; 401(4):423-434. PubMed ID: 31782942
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.
    James KA; Verkhivker GM
    PLoS One; 2014; 9(11):e113488. PubMed ID: 25427151
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dissecting Structure-Encoded Determinants of Allosteric Cross-Talk between Post-Translational Modification Sites in the Hsp90 Chaperones.
    Stetz G; Tse A; Verkhivker GM
    Sci Rep; 2018 May; 8(1):6899. PubMed ID: 29720613
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.