BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

279 related articles for article (PubMed ID: 24927996)

  • 21. Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.
    Jiang F; Wang HJ; Bao QC; Wang L; Jin YH; Zhang Q; Jiang D; You QD; Xu XL
    Bioorg Med Chem; 2016 Nov; 24(21):5431-5439. PubMed ID: 27647369
    [TBL] [Abstract][Full Text] [Related]  

  • 22. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells.
    Zhang T; Hamza A; Cao X; Wang B; Yu S; Zhan CG; Sun D
    Mol Cancer Ther; 2008 Jan; 7(1):162-70. PubMed ID: 18202019
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Expression and purification of recombinant NRL-Hsp90α and Cdc37-CRL proteins for in vitro Hsp90/Cdc37 inhibitors screening.
    He J; Niu X; Hu C; Zhang H; Guo Y; Ge Y; Wang G; Jiang Y
    Protein Expr Purif; 2013 Nov; 92(1):119-27. PubMed ID: 24056254
    [TBL] [Abstract][Full Text] [Related]  

  • 24. CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.
    Xu XL; Bao QC; Jia JM; Liu F; Guo XK; Zhang MY; Wei JL; Lu MC; Xu LL; Zhang XJ; You QD; Sun HP
    Sci Rep; 2016 Jan; 6():19004. PubMed ID: 26743233
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.
    Wang L; Li L; Zhou ZH; Jiang ZY; You QD; Xu XL
    Eur J Med Chem; 2017 Aug; 136():63-73. PubMed ID: 28482218
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance.
    Jin L; Huang R; Huang X; Zhang B; Ji M; Wang H
    Bioorg Med Chem; 2018 May; 26(8):1759-1775. PubMed ID: 29486954
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning.
    Smith JR; Workman P
    Cell Cycle; 2009 Feb; 8(3):362-72. PubMed ID: 19177013
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Medium-Throughput Detection of Hsp90/Cdc37 Protein-Protein Interaction Inhibitors Using a Split
    Siddiqui FA; Parkkola H; Manoharan GB; Abankwa D
    SLAS Discov; 2020 Feb; 25(2):195-206. PubMed ID: 31662027
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.
    Wang L; Jiang J; Zhang L; Zhang Q; Zhou J; Li L; Xu X; You Q
    J Med Chem; 2020 Feb; 63(3):1281-1297. PubMed ID: 31935086
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
    Yu Y; Hamza A; Zhang T; Gu M; Zou P; Newman B; Li Y; Gunatilaka AA; Zhan CG; Sun D
    Biochem Pharmacol; 2010 Feb; 79(4):542-51. PubMed ID: 19769945
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.
    Ota A; Zhang J; Ping P; Han J; Wang Y
    Circ Res; 2010 Apr; 106(8):1404-12. PubMed ID: 20299663
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.
    Zhang H; Wu W; Du Y; Santos SJ; Conrad SE; Watson JT; Grammatikakis N; Gallo KA
    J Biol Chem; 2004 May; 279(19):19457-63. PubMed ID: 15001580
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.
    Donnelly A; Blagg BS
    Curr Med Chem; 2008; 15(26):2702-17. PubMed ID: 18991631
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.
    Eckl JM; Rutz DA; Haslbeck V; Zierer BK; Reinstein J; Richter K
    J Biol Chem; 2013 May; 288(22):16032-42. PubMed ID: 23569206
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.
    Li R; Yuan F; Fu W; Zhang L; Zhang N; Wang Y; Ma K; Li X; Wang L; Zhu WG; Zhao Y
    J Biol Chem; 2017 Feb; 292(7):2830-2841. PubMed ID: 28073914
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines.
    Zhao YR; Li HM; Zhu M; Li J; Ma T; Huo Q; Hong YS; Wu CZ
    J Microbiol Biotechnol; 2018 Apr; 28(4):542-550. PubMed ID: 29618179
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy.
    Sreeramulu S; Jonker HR; Langer T; Richter C; Lancaster CR; Schwalbe H
    J Biol Chem; 2009 Feb; 284(6):3885-96. PubMed ID: 19073599
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor.
    Li T; Chen X; Dai XY; Wei B; Weng QJ; Chen X; Ouyang DF; Yan R; Huang ZJ; Jiang HL; Zhu H; Lu JJ
    Toxicol Appl Pharmacol; 2017 Sep; 330():65-73. PubMed ID: 28711525
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites.
    Eckl JM; Scherr MJ; Freiburger L; Daake MA; Sattler M; Richter K
    J Biol Chem; 2015 Dec; 290(52):30843-54. PubMed ID: 26511315
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90.
    Mehta PP; Whalen P; Baxi SM; Kung PP; Yamazaki S; Yin MJ
    Clin Cancer Res; 2011 Aug; 17(16):5432-42. PubMed ID: 21715568
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.