Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 24933731)

  • 1. Phosphorylation of Akt at the C-terminal tail triggers Akt activation.
    Liu P; Wang Z; Wei W
    Cell Cycle; 2014; 13(14):2162-4. PubMed ID: 24933731
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
    Liu P; Begley M; Michowski W; Inuzuka H; Ginzberg M; Gao D; Tsou P; Gan W; Papa A; Kim BM; Wan L; Singh A; Zhai B; Yuan M; Wang Z; Gygi SP; Lee TH; Lu KP; Toker A; Pandolfi PP; Asara JM; Kirschner MW; Sicinski P; Cantley L; Wei W
    Nature; 2014 Apr; 508(7497):541-5. PubMed ID: 24670654
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK; Pizzo SV
    PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.
    Yang G; Murashige DS; Humphrey SJ; James DE
    Cell Rep; 2015 Aug; 12(6):937-43. PubMed ID: 26235620
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.
    Zhang J; Xu K; Liu P; Geng Y; Wang B; Gan W; Guo J; Wu F; Chin YR; Berrios C; Lien EC; Toker A; DeCaprio JA; Sicinski P; Wei W
    Mol Cell; 2016 Jun; 62(6):929-942. PubMed ID: 27237051
    [TBL] [Abstract][Full Text] [Related]  

  • 6. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
    Woo SY; Kim DH; Jun CB; Kim YM; Haar EV; Lee SI; Hegg JW; Bandhakavi S; Griffin TJ; Kim DH
    J Biol Chem; 2007 Aug; 282(35):25604-12. PubMed ID: 17599906
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.
    Zhao X; Lu S; Nie J; Hu X; Luo W; Wu X; Liu H; Feng Q; Chang Z; Liu Y; Cao Y; Sun H; Li X; Hu Y; Yang Z
    Mol Cell Biol; 2014 Jun; 34(11):1966-75. PubMed ID: 24662050
    [TBL] [Abstract][Full Text] [Related]  

  • 8. mTOR complex 2 mediates Akt phosphorylation that requires PKCε in adult cardiac muscle cells.
    Moschella PC; McKillop J; Pleasant DL; Harston RK; Balasubramanian S; Kuppuswamy D
    Cell Signal; 2013 Sep; 25(9):1904-12. PubMed ID: 23673367
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.
    Chen CH; Kiyan V; Zhylkibayev AA; Kazyken D; Bulgakova O; Page KE; Bersimbaev RI; Spooner E; Sarbassov DD
    J Biol Chem; 2013 Sep; 288(38):27019-27030. PubMed ID: 23928304
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
    Najafov A; Shpiro N; Alessi DR
    Biochem J; 2012 Dec; 448(2):285-95. PubMed ID: 23030823
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
    Liu P; Gan W; Inuzuka H; Lazorchak AS; Gao D; Arojo O; Liu D; Wan L; Zhai B; Yu Y; Yuan M; Kim BM; Shaik S; Menon S; Gygi SP; Lee TH; Asara JM; Manning BD; Blenis J; Su B; Wei W
    Nat Cell Biol; 2013 Nov; 15(11):1340-50. PubMed ID: 24161930
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
    Misra UK; Pizzo SV
    J Cell Biochem; 2012 May; 113(5):1488-500. PubMed ID: 22173835
    [TBL] [Abstract][Full Text] [Related]  

  • 13. BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
    Yao Y; Suraokar M; Darnay BG; Hollier BG; Shaiken TE; Asano T; Chen CH; Chang BH; Lu Y; Mills GB; Sarbassov D; Mani SA; Abbruzzese JL; Reddy SA
    Sci Signal; 2013 Jan; 6(257):ra2. PubMed ID: 23300339
    [TBL] [Abstract][Full Text] [Related]  

  • 14. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy.
    Das F; Ghosh-Choudhury N; Mariappan MM; Kasinath BS; Choudhury GG
    Am J Physiol Cell Physiol; 2016 Apr; 310(7):C583-96. PubMed ID: 26739493
    [TBL] [Abstract][Full Text] [Related]  

  • 16. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
    Kim SJ; DeStefano MA; Oh WJ; Wu CC; Vega-Cotto NM; Finlan M; Liu D; Su B; Jacinto E
    Mol Cell; 2012 Dec; 48(6):875-87. PubMed ID: 23142081
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.
    Chan TO; Zhang J; Tiegs BC; Blumhof B; Yan L; Keny N; Penny M; Li X; Pascal JM; Armen RS; Rodeck U; Penn RB
    Biochem J; 2015 Oct; 471(1):37-51. PubMed ID: 26201515
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation.
    Lee CJ; Jang JH; Lee JY; Lee MH; Li Y; Ryu HW; Choi KI; Dong Z; Lee HS; Oh SR; Surh YJ; Cho YY
    Carcinogenesis; 2015 Oct; 36(10):1223-34. PubMed ID: 26243309
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.
    Lee SL; Chou CC; Chuang HC; Hsu EC; Chiu PC; Kulp SK; Byrd JC; Chen CS
    PLoS One; 2013; 8(6):e67149. PubMed ID: 23840605
    [TBL] [Abstract][Full Text] [Related]  

  • 20. RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.
    Cailliau K; Lescuyer A; Burnol AF; Cuesta-Marbán Á; Widmann C; Browaeys-Poly E
    J Biol Chem; 2015 Aug; 290(32):19653-65. PubMed ID: 26109071
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.