BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

415 related articles for article (PubMed ID: 24946055)

  • 1. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains.
    Hay DA; Fedorov O; Martin S; Singleton DC; Tallant C; Wells C; Picaud S; Philpott M; Monteiro OP; Rogers CM; Conway SJ; Rooney TP; Tumber A; Yapp C; Filippakopoulos P; Bunnage ME; Müller S; Knapp S; Schofield CJ; Brennan PE
    J Am Chem Soc; 2014 Jul; 136(26):9308-19. PubMed ID: 24946055
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
    Brand M; Clayton J; Moroglu M; Schiedel M; Picaud S; Bluck JP; Skwarska A; Bolland H; Chan AKN; Laurin CMC; Scorah AR; See L; Rooney TPC; Andrews KH; Fedorov O; Perell G; Kalra P; Vinh KB; Cortopassi WA; Heitel P; Christensen KE; Cooper RI; Paton RS; Pomerantz WCK; Biggin PC; Hammond EM; Filippakopoulos P; Conway SJ
    J Med Chem; 2021 Jul; 64(14):10102-10123. PubMed ID: 34255515
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of Dimethylisoxazole-Attached Imidazo[1,2-
    Muthengi A; Wimalasena VK; Yosief HO; Bikowitz MJ; Sigua LH; Wang T; Li D; Gaieb Z; Dhawan G; Liu S; Erickson J; Amaro RE; Schönbrunn E; Qi J; Zhang W
    J Med Chem; 2021 May; 64(9):5787-5801. PubMed ID: 33872011
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain.
    Chen Y; Bi X; Zhang F; Sun Z; Xu P; Jiang H; Lu W; Lu T; Ding H; Zhang N; Jiang H; Chen K; Zhou B; Luo C
    Bioorg Chem; 2020 Aug; 101():103991. PubMed ID: 32559581
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
    Ghosh S; Taylor A; Chin M; Huang HR; Conery AR; Mertz JA; Salmeron A; Dakle PJ; Mele D; Cote A; Jayaram H; Setser JW; Poy F; Hatzivassiliou G; DeAlmeida-Nagata D; Sandy P; Hatton C; Romero FA; Chiang E; Reimer T; Crawford T; Pardo E; Watson VG; Tsui V; Cochran AG; Zawadzke L; Harmange JC; Audia JE; Bryant BM; Cummings RT; Magnuson SR; Grogan JL; Bellon SF; Albrecht BK; Sims RJ; Lora JM
    J Biol Chem; 2016 Jun; 291(25):13014-27. PubMed ID: 27056325
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening.
    Zhang FC; Sun ZY; Liao LP; Zuo Y; Zhang D; Wang J; Chen YT; Xiao SH; Jiang H; Lu T; Xu P; Yue LY; Du DH; Zhang H; Liu CP; Luo C
    Acta Pharmacol Sin; 2020 Feb; 41(2):286-292. PubMed ID: 31253937
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
    Unzue A; Zhao H; Lolli G; Dong J; Zhu J; Zechner M; Dolbois A; Caflisch A; Nevado C
    J Med Chem; 2016 Apr; 59(7):3087-97. PubMed ID: 26982797
    [TBL] [Abstract][Full Text] [Related]  

  • 8. CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
    Hammitzsch A; Tallant C; Fedorov O; O'Mahony A; Brennan PE; Hay DA; Martinez FO; Al-Mossawi MH; de Wit J; Vecellio M; Wells C; Wordsworth P; Müller S; Knapp S; Bowness P
    Proc Natl Acad Sci U S A; 2015 Aug; 112(34):10768-73. PubMed ID: 26261308
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.
    Chaikuad A; Lang S; Brennan PE; Temperini C; Fedorov O; Hollander J; Nachane R; Abell C; Müller S; Siegal G; Knapp S
    J Med Chem; 2016 Feb; 59(4):1648-53. PubMed ID: 26731131
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
    Hewings DS; Wang M; Philpott M; Fedorov O; Uttarkar S; Filippakopoulos P; Picaud S; Vuppusetty C; Marsden B; Knapp S; Conway SJ; Heightman TD
    J Med Chem; 2011 Oct; 54(19):6761-70. PubMed ID: 21851057
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.
    Ebrahimi A; Sevinç K; Gürhan Sevinç G; Cribbs AP; Philpott M; Uyulur F; Morova T; Dunford JE; Göklemez S; Arı Ş; Oppermann U; Önder TT
    Nat Chem Biol; 2019 May; 15(5):519-528. PubMed ID: 30962627
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.
    Vannam R; Sayilgan J; Ojeda S; Karakyriakou B; Hu E; Kreuzer J; Morris R; Herrera Lopez XI; Rai S; Haas W; Lawrence M; Ott CJ
    Cell Chem Biol; 2021 Apr; 28(4):503-514.e12. PubMed ID: 33400925
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of 8-Methyl-pyrrolo[1,2-
    Li Z; Xiao S; Yang Y; Chen C; Lu T; Chen Z; Jiang H; Chen S; Luo C; Zhou B
    J Med Chem; 2020 Apr; 63(8):3956-3975. PubMed ID: 32208600
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD.
    Wei L; Jamonnak N; Choy J; Wang Z; Zheng W
    Biochem Biophys Res Commun; 2008 Apr; 368(2):279-84. PubMed ID: 18222173
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Classical molecular dynamics and metadynamics simulations decipher the mechanism of CBP30 selectively inhibiting CBP/p300 bromodomains.
    Wang Q; An X; Xu J; Wang Y; Liu L; Leung EL; Yao X
    Org Biomol Chem; 2018 Sep; 16(35):6521-6530. PubMed ID: 30160288
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.
    Chekler EL; Pellegrino JA; Lanz TA; Denny RA; Flick AC; Coe J; Langille J; Basak A; Liu S; Stock IA; Sahasrabudhe P; Bonin PD; Lee K; Pletcher MT; Jones LH
    Chem Biol; 2015 Dec; 22(12):1588-96. PubMed ID: 26670081
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites.
    Olp MD; Sprague DJ; Goetz CJ; Kathman SG; Wynia-Smith SL; Shishodia S; Summers SB; Xu Z; Statsyuk AV; Smith BC
    ACS Chem Biol; 2020 Apr; 15(4):1036-1049. PubMed ID: 32149490
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia.
    Imayoshi N; Yoshioka M; Tanaka K; Yang SM; Akahane K; Toda Y; Hosogi S; Inukai T; Okada S; Maloney DJ; Nakahata T; Takita J; Kato I; Ashihara E
    Biochem Biophys Res Commun; 2022 Jan; 590():49-54. PubMed ID: 34971957
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
    Yang Y; Zhang R; Li Z; Mei L; Wan S; Ding H; Chen Z; Xing J; Feng H; Han J; Jiang H; Zheng M; Luo C; Zhou B
    J Med Chem; 2020 Feb; 63(3):1337-1360. PubMed ID: 31910017
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.
    Denny RA; Flick AC; Coe J; Langille J; Basak A; Liu S; Stock I; Sahasrabudhe P; Bonin P; Hay DA; Brennan PE; Pletcher M; Jones LH; Chekler ELP
    J Med Chem; 2017 Jul; 60(13):5349-5363. PubMed ID: 28375629
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.