These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

83 related articles for article (PubMed ID: 24968066)

  • 1. Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides.
    Xin BT; de Bruin G; Verdoes M; Filippov DV; van der Marel GA; Overkleeft HS
    Org Biomol Chem; 2014 Aug; 12(30):5710-8. PubMed ID: 24968066
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of Novel Epoxyketone Peptides as Lipase Inhibitors.
    Almaliti J; Alzweiri M; Alhindy M; Al-Helo T; Daoud I; Deknash R; Naman CB; Abu-Irmaileh B; Bustanji Y; Hamad I
    Molecules; 2022 Mar; 27(7):. PubMed ID: 35408660
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.
    Kawamura S; Unno Y; Asai A; Arisawa M; Shuto S
    Bioorg Med Chem; 2014 Jun; 22(12):3091-5. PubMed ID: 24814885
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif.
    Stein ML; Cui H; Beck P; Dubiella C; Voss C; Krüger A; Schmidt B; Groll M
    Angew Chem Int Ed Engl; 2014 Feb; 53(6):1679-83. PubMed ID: 24403024
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development of peptide epoxyketones as selective immunoproteasome inhibitors.
    Li X; Hong D; Zhang M; Xu L; Zhou Y; Li J; Liu T
    Eur J Med Chem; 2021 Oct; 221():113556. PubMed ID: 34087498
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.
    Huber EM; de Bruin G; Heinemeyer W; Paniagua Soriano G; Overkleeft HS; Groll M
    J Am Chem Soc; 2015 Jun; 137(24):7835-42. PubMed ID: 26020686
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors.
    Zhang J; Cao J; Xu L; Zhou Y; Liu T; Li J; Hu Y
    Bioorg Med Chem; 2014 Jun; 22(11):2955-65. PubMed ID: 24767818
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Epoxomicin and Eponemycin Biosynthesis Involves gem-Dimethylation and an Acyl-CoA Dehydrogenase-Like Enzyme.
    Zettler J; Zubeil F; Kulik A; Grond S; Kaysser L
    Chembiochem; 2016 May; 17(9):792-8. PubMed ID: 26789439
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.
    Owen JG; Charlop-Powers Z; Smith AG; Ternei MA; Calle PY; Reddy BV; Montiel D; Brady SF
    Proc Natl Acad Sci U S A; 2015 Apr; 112(14):4221-6. PubMed ID: 25831524
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Peptido sulfonyl fluorides as new powerful proteasome inhibitors.
    Brouwer AJ; Jonker A; Werkhoven P; Kuo E; Li N; Gallastegui N; Kemmink J; Florea BI; Groll M; Overkleeft HS; Liskamp RM
    J Med Chem; 2012 Dec; 55(24):10995-1003. PubMed ID: 23170994
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF.
    Corless BC; Geißen R; Prescott NA; David Y; Scheinberg DA; Tan DS
    ACS Chem Biol; 2023 Jun; 18(6):1360-1367. PubMed ID: 37172287
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of Degradation of an α-Keto-Epoxide, a Model for the Warhead for Various Proteasome Inhibitor Anticancer Agents.
    Phizackerley KM; Jumaa M; Lopalco A; Wolfe BH; Ablan CD; Stella VJ
    J Pharm Sci; 2017 Apr; 106(4):1051-1061. PubMed ID: 28007565
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors.
    Risseeuw MD; Florea BI; van der Marel GA; Overkleeft HS; Overhand M
    Bioorg Chem; 2010 Oct; 38(5):202-9. PubMed ID: 20493511
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells.
    Federspiel JD; Codreanu SG; Goyal S; Albertolle ME; Lowe E; Teague J; Wong H; Guengerich FP; Liebler DC
    Mol Cell Proteomics; 2016 Oct; 15(10):3233-3242. PubMed ID: 27503896
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.
    Schorn M; Zettler J; Noel JP; Dorrestein PC; Moore BS; Kaysser L
    ACS Chem Biol; 2014 Jan; 9(1):301-9. PubMed ID: 24168704
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones.
    van der Linden WA; Willems LI; Shabaneh TB; Li N; Ruben M; Florea BI; van der Marel GA; Kaiser M; Kisselev AF; Overkleeft HS
    Org Biomol Chem; 2012 Jan; 10(1):181-94. PubMed ID: 22105930
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides.
    Brouwer AJ; Herrero Álvarez N; Ciaffoni A; van de Langemheen H; Liskamp RM
    Bioorg Med Chem; 2016 Aug; 24(16):3429-35. PubMed ID: 27316540
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome.
    Keller L; Plaza A; Dubiella C; Groll M; Kaiser M; Müller R
    J Am Chem Soc; 2015 Jul; 137(25):8121-30. PubMed ID: 26050527
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of the 26S proteasome by peptide mimics of the coiled-coil region of its ATPase subunits.
    Inobe T; Genmei R
    Biochem Biophys Res Commun; 2015 Dec 4-11; 468(1-2):143-50. PubMed ID: 26522225
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases).
    James KE; Götz MG; Caffrey CR; Hansell E; Carter W; Barrett AJ; McKerrow JH; Powers JC
    Biol Chem; 2003 Dec; 384(12):1613-8. PubMed ID: 14719804
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.