190 related articles for article (PubMed ID: 24975935)
1. Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.
Shaw GX; Li Y; Shi G; Wu Y; Cherry S; Needle D; Zhang D; Tropea JE; Waugh DS; Yan H; Ji X
FEBS J; 2014 Sep; 281(18):4123-37. PubMed ID: 24975935
[TBL] [Abstract][Full Text] [Related]
2. Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis.
Pemble CW; Mehta PK; Mehra S; Li Z; Nourse A; Lee RE; White SW
PLoS One; 2010 Nov; 5(11):e14165. PubMed ID: 21152407
[TBL] [Abstract][Full Text] [Related]
3. 8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.
Dennis ML; Lee MD; Harjani JR; Ahmed M; DeBono AJ; Pitcher NP; Wang ZC; Chhabra S; Barlow N; Rahmani R; Cleary B; Dolezal O; Hattarki M; Aurelio L; Shonberg J; Graham B; Peat TS; Baell JB; Swarbrick JD
Chemistry; 2018 Feb; 24(8):1922-1930. PubMed ID: 29171692
[TBL] [Abstract][Full Text] [Related]
4. Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from
Yogavel M; Nettleship JE; Sharma A; Harlos K; Jamwal A; Chaturvedi R; Sharma M; Jain V; Chhibber-Goel J; Sharma A
J Biol Chem; 2018 Sep; 293(39):14962-14972. PubMed ID: 30104413
[TBL] [Abstract][Full Text] [Related]
5. Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities.
Mouillon JM; Ravanel S; Douce R; Rébeillé F
Biochem J; 2002 Apr; 363(Pt 2):313-9. PubMed ID: 11931659
[TBL] [Abstract][Full Text] [Related]
6. Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action.
Baca AM; Sirawaraporn R; Turley S; Sirawaraporn W; Hol WG
J Mol Biol; 2000 Oct; 302(5):1193-212. PubMed ID: 11007651
[TBL] [Abstract][Full Text] [Related]
7. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies.
Shi G; Blaszczyk J; Ji X; Yan H
J Med Chem; 2001 Apr; 44(9):1364-71. PubMed ID: 11311059
[TBL] [Abstract][Full Text] [Related]
8. Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase.
de Beer TA; Louw AI; Joubert F
Bioorg Med Chem; 2006 Jul; 14(13):4433-43. PubMed ID: 16517168
[TBL] [Abstract][Full Text] [Related]
9. Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution.
Blaszczyk J; Shi G; Yan H; Ji X
Structure; 2000 Oct; 8(10):1049-58. PubMed ID: 11080626
[TBL] [Abstract][Full Text] [Related]
10. Probing the roles of non-homologous insertions in the N-terminal domain of Plasmodium falciparum hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase.
Rattanachuen W; Jönsson M; Swedberg G; Sirawaraporn W
Mol Biochem Parasitol; 2009 Dec; 168(2):135-42. PubMed ID: 19631695
[TBL] [Abstract][Full Text] [Related]
11. Purification, properties, and crystallization of Saccharomyces cerevisiae dihydropterin pyrophosphokinase-dihydropteroate synthase.
Berglez J; Pilling P; Macreadie I; Fernley RT
Protein Expr Purif; 2005 Jun; 41(2):355-62. PubMed ID: 15866722
[TBL] [Abstract][Full Text] [Related]
12. Structure of aspartate β-semialdehyde dehydrogenase from Francisella tularensis.
Mank NJ; Pote S; Majorek KA; Arnette AK; Klapper VG; Hurlburt BK; Chruszcz M
Acta Crystallogr F Struct Biol Commun; 2018 Jan; 74(Pt 1):14-22. PubMed ID: 29372903
[TBL] [Abstract][Full Text] [Related]
13. Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).
Mehboob S; Song J; Hevener KE; Su PC; Boci T; Brubaker L; Truong L; Mistry T; Deng J; Cook JL; Santarsiero BD; Ghosh AK; Johnson ME
Bioorg Med Chem Lett; 2015 Mar; 25(6):1292-6. PubMed ID: 25677657
[TBL] [Abstract][Full Text] [Related]
14. The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae.
Lawrence MC; Iliades P; Fernley RT; Berglez J; Pilling PA; Macreadie IG
J Mol Biol; 2005 May; 348(3):655-70. PubMed ID: 15826662
[TBL] [Abstract][Full Text] [Related]
15. Crystal structures of APRT from Francisella tularensis - an N-H···N hydrogen bond imparts adenine specificity in adenine phosporibosyltransferases.
Pavithra GC; Ramagopal UA
FEBS J; 2018 Jun; 285(12):2306-2318. PubMed ID: 29694705
[TBL] [Abstract][Full Text] [Related]
16. Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.
Dennis ML; Chhabra S; Wang ZC; Debono A; Dolezal O; Newman J; Pitcher NP; Rahmani R; Cleary B; Barlow N; Hattarki M; Graham B; Peat TS; Baell JB; Swarbrick JD
J Med Chem; 2014 Nov; 57(22):9612-26. PubMed ID: 25357262
[TBL] [Abstract][Full Text] [Related]
17. Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors.
Mehboob S; Hevener KE; Truong K; Boci T; Santarsiero BD; Johnson ME
J Med Chem; 2012 Jun; 55(12):5933-41. PubMed ID: 22642319
[TBL] [Abstract][Full Text] [Related]
18. Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam.
Vadlamani G; Sukhoverkov KV; Haywood J; Breese KJ; Fisher MF; Stubbs KA; Bond CS; Mylne JS
Plant Commun; 2022 Jul; 3(4):100322. PubMed ID: 35605193
[TBL] [Abstract][Full Text] [Related]
19. The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
Chitnumsub P; Jaruwat A; Talawanich Y; Noytanom K; Liwnaree B; Poen S; Yuthavong Y
FEBS J; 2020 Aug; 287(15):3273-3297. PubMed ID: 31883412
[TBL] [Abstract][Full Text] [Related]
20. The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Yun MK; Hoagland D; Kumar G; Waddell MB; Rock CO; Lee RE; White SW
Bioorg Med Chem; 2014 Apr; 22(7):2157-65. PubMed ID: 24613625
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]