189 related articles for article (PubMed ID: 24997604)
1. A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.
Nolte WM; Fortin JP; Stevens BD; Aspnes GE; Griffith DA; Hoth LR; Ruggeri RB; Mathiowetz AM; Limberakis C; Hepworth D; Carpino PA
Nat Chem Biol; 2014 Aug; 10(8):629-31. PubMed ID: 24997604
[TBL] [Abstract][Full Text] [Related]
2. Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor.
Eng H; Sharma R; McDonald TS; Edmonds DJ; Fortin JP; Li X; Stevens BD; Griffith DA; Limberakis C; Nolte WM; Price DA; Jackson M; Kalgutkar AS
Drug Metab Dispos; 2013 Aug; 41(8):1470-9. PubMed ID: 23653442
[TBL] [Abstract][Full Text] [Related]
3. Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles.
Bueno AB; Showalter AD; Wainscott DB; Stutsman C; Marín A; Ficorilli J; Cabrera O; Willard FS; Sloop KW
J Biol Chem; 2016 May; 291(20):10700-15. PubMed ID: 26975372
[TBL] [Abstract][Full Text] [Related]
4. Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP: A novel tool to probe GLP-1R pharmacology.
Willard FS; Ho JD; Sloop KW
Adv Pharmacol; 2020; 88():173-191. PubMed ID: 32416867
[TBL] [Abstract][Full Text] [Related]
5. Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.
Koole C; Wootten D; Simms J; Miller LJ; Christopoulos A; Sexton PM
J Pharmacol Exp Ther; 2015 Apr; 353(1):52-63. PubMed ID: 25630467
[TBL] [Abstract][Full Text] [Related]
6. Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently.
Cheong YH; Kim MK; Son MH; Kaang BK
Biochem Biophys Res Commun; 2012 Jan; 417(1):558-63. PubMed ID: 22177947
[TBL] [Abstract][Full Text] [Related]
7. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.
Koole C; Wootten D; Simms J; Miller LJ; Christopoulos A; Sexton PM
J Biol Chem; 2012 Feb; 287(6):3642-58. PubMed ID: 22147710
[TBL] [Abstract][Full Text] [Related]
8. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
Koole C; Wootten D; Simms J; Savage EE; Miller LJ; Christopoulos A; Sexton PM
J Biol Chem; 2012 Feb; 287(6):3659-73. PubMed ID: 22147709
[TBL] [Abstract][Full Text] [Related]
9. A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors.
Morris LC; Days EL; Turney M; Mi D; Lindsley CW; Weaver CD; Niswender KD
J Biomol Screen; 2014 Jul; 19(6):847-58. PubMed ID: 24525870
[TBL] [Abstract][Full Text] [Related]
10. Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.
Koole C; Wootten D; Simms J; Valant C; Miller LJ; Christopoulos A; Sexton PM
Mol Pharmacol; 2011 Sep; 80(3):486-97. PubMed ID: 21616920
[TBL] [Abstract][Full Text] [Related]
11. Transmembrane α-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor.
Rye Underwood C; Møller Knudsen S; Schjellerup Wulff B; Bräuner-Osborne H; Lau J; Knudsen LB; Peters GH; Reedtz-Runge S
Pharmacology; 2011; 88(5-6):340-8. PubMed ID: 22134089
[TBL] [Abstract][Full Text] [Related]
12. Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(7-36) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor.
Coopman K; Huang Y; Johnston N; Bradley SJ; Wilkinson GF; Willars GB
J Pharmacol Exp Ther; 2010 Sep; 334(3):795-808. PubMed ID: 20507928
[TBL] [Abstract][Full Text] [Related]
13. Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor.
Cong Z; Chen LN; Ma H; Zhou Q; Zou X; Ye C; Dai A; Liu Q; Huang W; Sun X; Wang X; Xu P; Zhao L; Xia T; Zhong W; Yang D; Eric Xu H; Zhang Y; Wang MW
Nat Commun; 2021 Jun; 12(1):3763. PubMed ID: 34145245
[TBL] [Abstract][Full Text] [Related]
14. A small molecule ligand of the glucagon-like peptide 1 receptor targets its amino-terminal hormone binding domain.
Tibaduiza EC; Chen C; Beinborn M
J Biol Chem; 2001 Oct; 276(41):37787-93. PubMed ID: 11498540
[TBL] [Abstract][Full Text] [Related]
15. Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.
Willard FS; Wootten D; Showalter AD; Savage EE; Ficorilli J; Farb TB; Bokvist K; Alsina-Fernandez J; Furness SG; Christopoulos A; Sexton PM; Sloop KW
Mol Pharmacol; 2012 Dec; 82(6):1066-73. PubMed ID: 22930710
[TBL] [Abstract][Full Text] [Related]
16. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Zhang M; Robitaille M; Showalter AD; Huang X; Liu Y; Bhattacharjee A; Willard FS; Han J; Froese S; Wei L; Gaisano HY; Angers S; Sloop KW; Dai FF; Wheeler MB
Mol Cell Proteomics; 2014 Nov; 13(11):3049-62. PubMed ID: 25044020
[TBL] [Abstract][Full Text] [Related]
17. Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for
Wang H; Hu W; Liu D; Wüthrich K
FEBS J; 2021 Jul; 288(13):4053-4063. PubMed ID: 33369025
[TBL] [Abstract][Full Text] [Related]
18. Discovery of small molecule positive allosteric modulators of the secretin receptor.
Dengler DG; Harikumar KG; Pollari S; Sun Q; Brown BT; Shinoki-Iwaya A; Ardecky R; Miller LJ; Sergienko EA
Biochem Pharmacol; 2021 Mar; 185():114451. PubMed ID: 33545115
[TBL] [Abstract][Full Text] [Related]
19. Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain.
West GM; Willard FS; Sloop KW; Showalter AD; Pascal BD; Griffin PR
PLoS One; 2014; 9(9):e105683. PubMed ID: 25180755
[TBL] [Abstract][Full Text] [Related]
20. Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor.
Coopman K; Wallis R; Robb G; Brown AJ; Wilkinson GF; Timms D; Willars GB
Mol Endocrinol; 2011 Oct; 25(10):1804-18. PubMed ID: 21868452
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
