161 related articles for article (PubMed ID: 24998512)
1. TR-FRET assays of Huntingtin protein fragments reveal temperature and polyQ length-dependent conformational changes.
Cui X; Liang Q; Liang Y; Lu M; Ding Y; Lu B
Sci Rep; 2014 Jul; 4():5601. PubMed ID: 24998512
[TBL] [Abstract][Full Text] [Related]
2. Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.
Fodale V; Kegulian NC; Verani M; Cariulo C; Azzollini L; Petricca L; Daldin M; Boggio R; Padova A; Kuhn R; Pacifici R; Macdonald D; Schoenfeld RC; Park H; Isas JM; Langen R; Weiss A; Caricasole A
PLoS One; 2014; 9(12):e112262. PubMed ID: 25464275
[TBL] [Abstract][Full Text] [Related]
3. Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells.
Wilbertz JH; Frappier J; Muller S; Gratzer S; Englaro W; Stanek LM; Calamini B
SLAS Discov; 2022 Jun; 27(4):219-228. PubMed ID: 35058188
[TBL] [Abstract][Full Text] [Related]
4. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis.
Zheng S; Ghitani N; Blackburn JS; Liu JP; Zeitlin SO
Mol Brain; 2012 Aug; 5():28. PubMed ID: 22892315
[TBL] [Abstract][Full Text] [Related]
5. TR-FRET Assays for Endogenous Huntingtin Protein Level in Mouse Cells.
Liang Y; Yao Y; Lu M; Hou J; Yu S; Lu B
J Huntingtons Dis; 2014; 3(3):253-9. PubMed ID: 25300329
[TBL] [Abstract][Full Text] [Related]
6. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
Busch A; Engemann S; Lurz R; Okazawa H; Lehrach H; Wanker EE
J Biol Chem; 2003 Oct; 278(42):41452-61. PubMed ID: 12888569
[TBL] [Abstract][Full Text] [Related]
7. Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.
Legleiter J; Mitchell E; Lotz GP; Sapp E; Ng C; DiFiglia M; Thompson LM; Muchowski PJ
J Biol Chem; 2010 May; 285(19):14777-90. PubMed ID: 20220138
[TBL] [Abstract][Full Text] [Related]
8. Anti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1.
Owens GE; New DM; West AP; Bjorkman PJ
J Mol Biol; 2015 Jul; 427(15):2507-2519. PubMed ID: 26047735
[TBL] [Abstract][Full Text] [Related]
9. Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity.
Khoshnan A; Ko J; Patterson PH
Proc Natl Acad Sci U S A; 2002 Jan; 99(2):1002-7. PubMed ID: 11792860
[TBL] [Abstract][Full Text] [Related]
10. New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins.
Ko J; Ou S; Patterson PH
Brain Res Bull; 2001 Oct-Nov 1; 56(3-4):319-29. PubMed ID: 11719267
[TBL] [Abstract][Full Text] [Related]
11. Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.
Legleiter J; Lotz GP; Miller J; Ko J; Ng C; Williams GL; Finkbeiner S; Patterson PH; Muchowski PJ
J Biol Chem; 2009 Aug; 284(32):21647-58. PubMed ID: 19491400
[TBL] [Abstract][Full Text] [Related]
12. Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.
Hoop CL; Lin HK; Kar K; Hou Z; Poirier MA; Wetzel R; van der Wel PC
Biochemistry; 2014 Oct; 53(42):6653-66. PubMed ID: 25280367
[TBL] [Abstract][Full Text] [Related]
13. Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions.
Davranche A; Aviolat H; Zeder-Lutz G; Busso D; Altschuh D; Trottier Y; Klein FA
Hum Mol Genet; 2011 Jul; 20(14):2795-806. PubMed ID: 21518730
[TBL] [Abstract][Full Text] [Related]
14. Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
Sahoo B; Arduini I; Drombosky KW; Kodali R; Sanders LH; Greenamyre JT; Wetzel R
PLoS One; 2016; 11(6):e0155747. PubMed ID: 27271685
[TBL] [Abstract][Full Text] [Related]
15. Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils.
Isas JM; Langen R; Siemer AB
Biochemistry; 2015 Jun; 54(25):3942-9. PubMed ID: 26020223
[TBL] [Abstract][Full Text] [Related]
16. Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.
Banerjee M; Datta M; Bhattacharyya NP
Int J Biochem Cell Biol; 2017 Jan; 82():1-9. PubMed ID: 27840155
[TBL] [Abstract][Full Text] [Related]
17. Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease.
Barbaro BA; Lukacsovich T; Agrawal N; Burke J; Bornemann DJ; Purcell JM; Worthge SA; Caricasole A; Weiss A; Song W; Morozova OA; Colby DW; Marsh JL
Hum Mol Genet; 2015 Feb; 24(4):913-25. PubMed ID: 25305076
[TBL] [Abstract][Full Text] [Related]
18. scyllo-Inositol promotes robust mutant Huntingtin protein degradation.
Lai AY; Lan CP; Hasan S; Brown ME; McLaurin J
J Biol Chem; 2014 Feb; 289(6):3666-76. PubMed ID: 24352657
[TBL] [Abstract][Full Text] [Related]
19. Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.
Jayaraman M; Kodali R; Sahoo B; Thakur AK; Mayasundari A; Mishra R; Peterson CB; Wetzel R
J Mol Biol; 2012 Feb; 415(5):881-99. PubMed ID: 22178474
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
Gafni J; Hermel E; Young JE; Wellington CL; Hayden MR; Ellerby LM
J Biol Chem; 2004 May; 279(19):20211-20. PubMed ID: 14981075
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]