These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

200 related articles for article (PubMed ID: 25002580)

  • 1. Deciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin.
    Avital-Shmilovici M; Whittaker J; Weiss MA; Kent SB
    J Biol Chem; 2014 Aug; 289(34):23683-92. PubMed ID: 25002580
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications.
    Yang Y; Glidden MD; Dhayalan B; Zaykov AN; Chen YS; Wickramasinghe NP; DiMarchi RD; Weiss MA
    Front Endocrinol (Lausanne); 2022; 13():821091. PubMed ID: 35299958
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.
    Sun J; Cui J; He Q; Chen Z; Arvan P; Liu M
    Mol Aspects Med; 2015 Apr; 42():105-18. PubMed ID: 25579745
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Diabetes-Associated Mutations in Proinsulin Provide a "Molecular Rheostat" of Nascent Foldability.
    Dhayalan B; Weiss MA
    Curr Diab Rep; 2022 Feb; 22(2):85-94. PubMed ID: 35119630
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation.
    Dhayalan B; Glidden MD; Zaykov AN; Chen YS; Yang Y; Phillips NB; Ismail-Beigi F; Jarosinski MA; DiMarchi RD; Weiss MA
    Front Endocrinol (Lausanne); 2022; 13():821069. PubMed ID: 35299972
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.
    Park SY; Ye H; Steiner DF; Bell GI
    Biochem Biophys Res Commun; 2010 Jan; 391(3):1449-54. PubMed ID: 20034470
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Diabetes mellitus due to the toxic misfolding of proinsulin variants.
    Weiss MA
    FEBS Lett; 2013 Jun; 587(13):1942-50. PubMed ID: 23669362
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural Lessons From the Mutant Proinsulin Syndrome.
    Dhayalan B; Chatterjee D; Chen YS; Weiss MA
    Front Endocrinol (Lausanne); 2021; 12():754693. PubMed ID: 34659132
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormone.
    Liu M; Hua QX; Hu SQ; Jia W; Yang Y; Saith SE; Whittaker J; Arvan P; Weiss MA
    J Biol Chem; 2010 Oct; 285(40):30989-1001. PubMed ID: 20663888
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations.
    Wang H; Saint-Martin C; Xu J; Ding L; Wang R; Feng W; Liu M; Shu H; Fan Z; Haataja L; Arvan P; Bellanné-Chantelot C; Cui J; Huang Y
    Mol Cell Endocrinol; 2020 Dec; 518():111025. PubMed ID: 32916194
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Distinct states of proinsulin misfolding in MIDY.
    Haataja L; Arunagiri A; Hassan A; Regan K; Tsai B; Dhayalan B; Weiss MA; Liu M; Arvan P
    Cell Mol Life Sci; 2021 Aug; 78(16):6017-6031. PubMed ID: 34245311
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Proinsulin and the genetics of diabetes mellitus.
    Weiss MA
    J Biol Chem; 2009 Jul; 284(29):19159-63. PubMed ID: 19395706
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.
    Rajan S; Eames SC; Park SY; Labno C; Bell GI; Prince VE; Philipson LH
    Am J Physiol Endocrinol Metab; 2010 Mar; 298(3):E403-10. PubMed ID: 19952343
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.
    Wright J; Birk J; Haataja L; Liu M; Ramming T; Weiss MA; Appenzeller-Herzog C; Arvan P
    J Biol Chem; 2013 Oct; 288(43):31010-8. PubMed ID: 24022479
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Proinsulin entry and transit through the endoplasmic reticulum in pancreatic beta cells.
    Liu M; Wright J; Guo H; Xiong Y; Arvan P
    Vitam Horm; 2014; 95():35-62. PubMed ID: 24559913
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain.
    Nakagawa SH; Zhao M; Hua QX; Hu SQ; Wan ZL; Jia W; Weiss MA
    Biochemistry; 2005 Apr; 44(13):4984-99. PubMed ID: 15794637
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evolution of insulin at the edge of foldability and its medical implications.
    Rege NK; Liu M; Yang Y; Dhayalan B; Wickramasinghe NP; Chen YS; Rahimi L; Guo H; Haataja L; Sun J; Ismail-Beigi F; Phillips NB; Arvan P; Weiss MA
    Proc Natl Acad Sci U S A; 2020 Nov; 117(47):29618-29628. PubMed ID: 33154160
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.
    Liu M; Hodish I; Haataja L; Lara-Lemus R; Rajpal G; Wright J; Arvan P
    Trends Endocrinol Metab; 2010 Nov; 21(11):652-9. PubMed ID: 20724178
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.
    Arunagiri A; Haataja L; Cunningham CN; Shrestha N; Tsai B; Qi L; Liu M; Arvan P
    Ann N Y Acad Sci; 2018 Apr; 1418(1):5-19. PubMed ID: 29377149
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural analysis of proinsulin hexamer assembly by hydroxyl radical footprinting and computational modeling.
    Kiselar JG; Datt M; Chance MR; Weiss MA
    J Biol Chem; 2011 Dec; 286(51):43710-43716. PubMed ID: 22033917
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.