BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

128 related articles for article (PubMed ID: 25002748)

  • 1. Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells.
    Bachour-El Azzi P; Sharanek A; Abdel-Razzak Z; Antherieu S; Al-Attrache H; Savary CC; Lepage S; Morel I; Labbe G; Guguen-Guillouzo C; Guillouzo A
    Drug Metab Dispos; 2014 Sep; 42(9):1556-66. PubMed ID: 25002748
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.
    Anthérieu S; Bachour-El Azzi P; Dumont J; Abdel-Razzak Z; Guguen-Guillouzo C; Fromenty B; Robin MA; Guillouzo A
    Hepatology; 2013 Apr; 57(4):1518-29. PubMed ID: 23175273
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Janus kinase-dependent regulation of drug detoxifying protein expression by interleukin-22 in human hepatic cells.
    Le Vée M; Bruyère A; Jouan E; Fardel O
    Int Immunopharmacol; 2020 Jun; 83():106439. PubMed ID: 32234672
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line.
    Morgan K; Martucci N; Kozlowska A; Gamal W; Brzeszczyński F; Treskes P; Samuel K; Hayes P; Nelson L; Bagnaninchi P; Brzeszczynska J; Plevris J
    Biomed Pharmacother; 2019 Mar; 111():1408-1416. PubMed ID: 30841456
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients.
    Nakai K; Tanaka H; Hanada K; Ogata H; Suzuki F; Kumada H; Miyajima A; Ishida S; Sunouchi M; Habano W; Kamikawa Y; Kubota K; Kita J; Ozawa S; Ohno Y
    Drug Metab Dispos; 2008 Sep; 36(9):1786-93. PubMed ID: 18515332
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation.
    Sharanek A; Burban A; Humbert L; Guguen-Guillouzo C; Rainteau D; Guillouzo A
    Drug Metab Dispos; 2017 Dec; 45(12):1292-1303. PubMed ID: 28928138
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs.
    Mita S; Suzuki H; Akita H; Hayashi H; Onuki R; Hofmann AF; Sugiyama Y
    Drug Metab Dispos; 2006 Sep; 34(9):1575-81. PubMed ID: 16760228
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells.
    Sharanek A; Azzi PB; Al-Attrache H; Savary CC; Humbert L; Rainteau D; Guguen-Guillouzo C; Guillouzo A
    Toxicol Sci; 2014 Sep; 141(1):244-53. PubMed ID: 24973091
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chlorpromazine-induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin-Chen-Hao-Tang.
    Yang Q; Yang F; Tang X; Ding L; Xu Y; Xiong Y; Wang Z; Yang L
    BMC Complement Altern Med; 2015 Apr; 15():122. PubMed ID: 25887351
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs.
    Notenboom S; Weigand KM; Proost JH; van Lipzig MMH; van de Steeg E; van den Broek PHH; Greupink R; Russel FGM; Groothuis GMM
    Eur J Pharm Sci; 2018 Mar; 115():175-184. PubMed ID: 29309877
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta.
    Le Vee M; Gripon P; Stieger B; Fardel O
    Drug Metab Dispos; 2008 Feb; 36(2):217-22. PubMed ID: 17991769
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity.
    Saran C; Fu D; Ho H; Klein A; Fallon JK; Honkakoski P; Brouwer KLR
    Sci Rep; 2022 Aug; 12(1):14333. PubMed ID: 35995956
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Expression and transport function of drug uptake transporters in differentiated HepaRG cells.
    Kotani N; Maeda K; Debori Y; Camus S; Li R; Chesne C; Sugiyama Y
    Mol Pharm; 2012 Dec; 9(12):3434-41. PubMed ID: 22897388
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters.
    Nguyen TV; Ukairo O; Khetani SR; McVay M; Kanchagar C; Seghezzi W; Ayanoglu G; Irrechukwu O; Evers R
    Drug Metab Dispos; 2015 May; 43(5):774-85. PubMed ID: 25739975
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.
    Burbank MG; Burban A; Sharanek A; Weaver RJ; Guguen-Guillouzo C; Guillouzo A
    Drug Metab Dispos; 2016 Nov; 44(11):1780-1793. PubMed ID: 27538918
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular regulation of sinusoidal liver bile acid transporters during cholestasis.
    Gartung C; Matern S
    Yale J Biol Med; 1997; 70(4):355-63. PubMed ID: 9626756
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy.
    Miura T; Kimura N; Yamada T; Shimizu T; Nanashima N; Yamana D; Hakamada K; Tsuchida S
    J Hepatol; 2011 Aug; 55(2):407-14. PubMed ID: 21167233
    [TBL] [Abstract][Full Text] [Related]  

  • 18. HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.
    Rubin K; Janefeldt A; Andersson L; Berke Z; Grime K; Andersson TB
    Drug Metab Dispos; 2015 Jan; 43(1):119-25. PubMed ID: 25371393
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.
    Sharanek A; Burban A; Humbert L; Bachour-El Azzi P; Felix-Gomes N; Rainteau D; Guillouzo A
    Toxicol Sci; 2015 Oct; 147(2):573-87. PubMed ID: 26198044
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.
    Fickert P; Fuchsbichler A; Marschall HU; Wagner M; Zollner G; Krause R; Zatloukal K; Jaeschke H; Denk H; Trauner M
    Am J Pathol; 2006 Feb; 168(2):410-22. PubMed ID: 16436656
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.