BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 2500406)

  • 1. Folinic acid modulation of fluorouracil: tissue kinetics of bolus administration.
    Spears CP; Gustavsson BG; Frösing R
    Invest New Drugs; 1989 Apr; 7(1):27-36. PubMed ID: 2500406
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil.
    Berger SH; Hakala MT
    Mol Pharmacol; 1984 Mar; 25(2):303-9. PubMed ID: 6608049
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.
    Spears CP; Gustavsson BG; Mitchell MS; Spicer D; Berne M; Bernstein L; Danenberg PV
    Cancer Res; 1984 Sep; 44(9):4144-50. PubMed ID: 6744325
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.
    Spears CP; Gustavsson BG; Berne M; Frösing R; Bernstein L; Hayes AA
    Cancer Res; 1988 Oct; 48(20):5894-900. PubMed ID: 3167844
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.
    Spears CP; Hayes AA; Shahinian AH; Danenberg PV; Frösing R; Gustavsson BG
    Biochem Pharmacol; 1989 Sep; 38(18):2985-93. PubMed ID: 2783153
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
    van der Wilt CL; Pinedo HM; Smid K; Cloos J; Noordhuis P; Peters GJ
    Semin Oncol; 1992 Apr; 19(2 Suppl 3):16-25. PubMed ID: 1532671
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
    Spears CP; Shahinian AH; Moran RG; Heidelberger C; Corbett TH
    Cancer Res; 1982 Feb; 42(2):450-6. PubMed ID: 6173112
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin.
    Allegra CJ; Chabner BA; Sholar PW; Bagley C; Drake JC; Lippman ME
    NCI Monogr; 1987; (5):199-202. PubMed ID: 3501543
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
    Ren Q; Van Groeningen CJ; Hardcastle A; Aherne GW; Geoffroy F; Allegra CJ; Johnston PG; Grem JL
    Oncol Res; 1997; 9(2):77-88. PubMed ID: 9167189
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin.
    Peters GJ; van Groeningen CJ; van der Wilt CL; Meijer S; Smid K; Laurensse E; Pinedo HM
    Semin Oncol; 1992 Apr; 19(2 Suppl 3):26-35. PubMed ID: 1557655
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma.
    Berne MH; Gustavsson BG; Almersjö O; Spears PC; Frösing R
    Cancer Chemother Pharmacol; 1986; 16(3):237-42. PubMed ID: 3698165
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.
    Peters GJ; van der Wilt CL; van Groeningen CJ; Smid K; Meijer S; Pinedo HM
    J Clin Oncol; 1994 Oct; 12(10):2035-42. PubMed ID: 7931471
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
    Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
    Houghton JA; Schmidt C; Houghton PJ
    Eur J Cancer Clin Oncol; 1982 Apr; 18(4):347-54. PubMed ID: 6889511
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Methods for thymidylate synthase pharmacodynamics: serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu assays.
    Spears CP; Gustavsson BG
    Adv Exp Med Biol; 1988; 244():97-106. PubMed ID: 3150252
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas.
    Van Laar JA; Rustum YM; Van der Wilt CL; Smid K; Kuiper CM; Pinedo HM; Peters GJ
    Cancer Chemother Pharmacol; 1996; 39(1-2):79-89. PubMed ID: 8995503
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells.
    Chen TL; Erlichman C
    Cancer Chemother Pharmacol; 1992; 30(5):370-6. PubMed ID: 1380407
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.
    Houghton JA; Maroda SJ; Phillips JO; Houghton PJ
    Cancer Res; 1981 Jan; 41(1):144-9. PubMed ID: 7448754
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase.
    van der Wilt CL; Smid K; Peters GJ
    Biochem Pharmacol; 2002 Aug; 64(4):669-75. PubMed ID: 12167486
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas.
    Houghton JA; Weiss KD; Williams LG; Torrance PM; Houghton PJ
    Biochem Pharmacol; 1986 Apr; 35(8):1351-8. PubMed ID: 3008760
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.