157 related articles for article (PubMed ID: 25007124)
1. N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
Ramachandran S; Hameed P S; Srivastava A; Shanbhag G; Morayya S; Rautela N; Awasthy D; Kavanagh S; Bharath S; Reddy J; Panduga V; Prabhakar KR; Saralaya R; Nanduri R; Raichurkar A; Menasinakai S; Achar V; Jiménez-Díaz MB; Martínez MS; Angulo-Barturen I; Ferrer S; Sanz LM; Gamo FJ; Duffy S; Avery VM; Waterson D; Lee MC; Coburn-Flynn O; Fidock DA; Iyer PS; Narayanan S; Hosagrahara V; Sambandamurthy VK
J Med Chem; 2014 Aug; 57(15):6642-52. PubMed ID: 25007124
[TBL] [Abstract][Full Text] [Related]
2. Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.
Hameed P S; Chinnapattu M; Shanbag G; Manjrekar P; Koushik K; Raichurkar A; Patil V; Jatheendranath S; Rudrapatna SS; Barde SP; Rautela N; Awasthy D; Morayya S; Narayan C; Kavanagh S; Saralaya R; Bharath S; Viswanath P; Mukherjee K; Bandodkar B; Srivastava A; Panduga V; Reddy J; Prabhakar KR; Sinha A; Jiménez-Díaz MB; Martínez MS; Angulo-Barturen I; Ferrer S; Sanz LM; Gamo FJ; Duffy S; Avery VM; Magistrado PA; Lukens AK; Wirth DF; Waterson D; Balasubramanian V; Iyer PS; Narayanan S; Hosagrahara V; Sambandamurthy VK; Ramachandran S
J Med Chem; 2014 Jul; 57(13):5702-13. PubMed ID: 24914738
[TBL] [Abstract][Full Text] [Related]
3. Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
Younis Y; Douelle F; González Cabrera D; Le Manach C; Nchinda AT; Paquet T; Street LJ; White KL; Zabiulla KM; Joseph JT; Bashyam S; Waterson D; Witty MJ; Wittlin S; Charman SA; Chibale K
J Med Chem; 2013 Nov; 56(21):8860-71. PubMed ID: 24099149
[TBL] [Abstract][Full Text] [Related]
4. Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Singh K; Okombo J; Brunschwig C; Ndubi F; Barnard L; Wilkinson C; Njogu PM; Njoroge M; Laing L; Machado M; Prudêncio M; Reader J; Botha M; Nondaba S; Birkholtz LM; Lauterbach S; Churchyard A; Coetzer TL; Burrows JN; Yeates C; Denti P; Wiesner L; Egan TJ; Wittlin S; Chibale K
J Med Chem; 2017 Feb; 60(4):1432-1448. PubMed ID: 28094524
[TBL] [Abstract][Full Text] [Related]
5. Antimalarial pyrido[1,2-a]benzimidazoles.
Ndakala AJ; Gessner RK; Gitari PW; October N; White KL; Hudson A; Fakorede F; Shackleford DM; Kaiser M; Yeates C; Charman SA; Chibale K
J Med Chem; 2011 Jul; 54(13):4581-9. PubMed ID: 21644541
[TBL] [Abstract][Full Text] [Related]
6. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.
Norcross NR; Baragaña B; Wilson C; Hallyburton I; Osuna-Cabello M; Norval S; Riley J; Stojanovski L; Simeons FR; Porzelle A; Grimaldi R; Wittlin S; Duffy S; Avery VM; Meister S; Sanz L; Jiménez-Díaz B; Angulo-Barturen I; Ferrer S; Martínez MS; Gamo FJ; Frearson JA; Gray DW; Fairlamb AH; Winzeler EA; Waterson D; Campbell SF; Willis P; Read KD; Gilbert IH
J Med Chem; 2016 Jul; 59(13):6101-20. PubMed ID: 27314305
[TBL] [Abstract][Full Text] [Related]
7. 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
Younis Y; Douelle F; Feng TS; González Cabrera D; Le Manach C; Nchinda AT; Duffy S; White KL; Shackleford DM; Morizzi J; Mannila J; Katneni K; Bhamidipati R; Zabiulla KM; Joseph JT; Bashyam S; Waterson D; Witty MJ; Hardick D; Wittlin S; Avery V; Charman SA; Chibale K
J Med Chem; 2012 Apr; 55(7):3479-87. PubMed ID: 22390538
[TBL] [Abstract][Full Text] [Related]
8. Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
González Cabrera D; Douelle F; Younis Y; Feng TS; Le Manach C; Nchinda AT; Street LJ; Scheurer C; Kamber J; White KL; Montagnat OD; Ryan E; Katneni K; Zabiulla KM; Joseph JT; Bashyam S; Waterson D; Witty MJ; Charman SA; Wittlin S; Chibale K
J Med Chem; 2012 Dec; 55(24):11022-30. PubMed ID: 23189922
[TBL] [Abstract][Full Text] [Related]
9. Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans.
Malmquist NA; Sundriyal S; Caron J; Chen P; Witkowski B; Menard D; Suwanarusk R; Renia L; Nosten F; Jiménez-Díaz MB; Angulo-Barturen I; Santos Martínez M; Ferrer S; Sanz LM; Gamo FJ; Wittlin S; Duffy S; Avery VM; Ruecker A; Delves MJ; Sinden RE; Fuchter MJ; Scherf A
Antimicrob Agents Chemother; 2015 Feb; 59(2):950-9. PubMed ID: 25421480
[TBL] [Abstract][Full Text] [Related]
10. 3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.
Das U; Singh RS; Alcorn J; Hickman MR; Sciotti RJ; Leed SE; Lee PJ; Roncal N; Dimmock JR
Bioorg Med Chem; 2013 Dec; 21(23):7250-6. PubMed ID: 24139941
[TBL] [Abstract][Full Text] [Related]
11. Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
Le Manach C; Gonzàlez Cabrera D; Douelle F; Nchinda AT; Younis Y; Taylor D; Wiesner L; White KL; Ryan E; March C; Duffy S; Avery VM; Waterson D; Witty MJ; Wittlin S; Charman SA; Street LJ; Chibale K
J Med Chem; 2014 Mar; 57(6):2789-98. PubMed ID: 24568587
[TBL] [Abstract][Full Text] [Related]
12. Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.
Paquet T; Gordon R; Waterson D; Witty MJ; Chibale K
Future Med Chem; 2012 Dec; 4(18):2265-77. PubMed ID: 23234550
[TBL] [Abstract][Full Text] [Related]
13. Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
Zhang YK; Plattner JJ; Easom EE; Jacobs RT; Guo D; Freund YR; Berry P; Ciaravino V; Erve JCL; Rosenthal PJ; Campo B; Gamo FJ; Sanz LM; Cao J
J Med Chem; 2017 Jul; 60(13):5889-5908. PubMed ID: 28635296
[TBL] [Abstract][Full Text] [Related]
14. A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.
Le Manach C; Paquet T; Brunschwig C; Njoroge M; Han Z; Gonzàlez Cabrera D; Bashyam S; Dhinakaran R; Taylor D; Reader J; Botha M; Churchyard A; Lauterbach S; Coetzer TL; Birkholtz LM; Meister S; Winzeler EA; Waterson D; Witty MJ; Wittlin S; Jiménez-Díaz MB; Santos Martínez M; Ferrer S; Angulo-Barturen I; Street LJ; Chibale K
J Med Chem; 2015 Nov; 58(21):8713-22. PubMed ID: 26502160
[TBL] [Abstract][Full Text] [Related]
15. Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
Le Manach C; Nchinda AT; Paquet T; Gonzàlez Cabrera D; Younis Y; Han Z; Bashyam S; Zabiulla M; Taylor D; Lawrence N; White KL; Charman SA; Waterson D; Witty MJ; Wittlin S; Botha ME; Nondaba SH; Reader J; Birkholtz LM; Jiménez-Díaz MB; Martínez MS; Ferrer S; Angulo-Barturen I; Meister S; Antonova-Koch Y; Winzeler EA; Street LJ; Chibale K
J Med Chem; 2016 Nov; 59(21):9890-9905. PubMed ID: 27748596
[TBL] [Abstract][Full Text] [Related]
16. Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2.
Le Manach C; Paquet T; Gonzàlez Cabrera D; Younis Y; Taylor D; Wiesner L; Lawrence N; Schwager S; Waterson D; Witty MJ; Wittlin S; Street LJ; Chibale K
J Med Chem; 2014 Nov; 57(21):8839-48. PubMed ID: 25313449
[TBL] [Abstract][Full Text] [Related]
17. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.
Witschel MC; Rottmann M; Schwab A; Leartsakulpanich U; Chitnumsub P; Seet M; Tonazzi S; Schwertz G; Stelzer F; Mietzner T; McNamara C; Thater F; Freymond C; Jaruwat A; Pinthong C; Riangrungroj P; Oufir M; Hamburger M; Mäser P; Sanz-Alonso LM; Charman S; Wittlin S; Yuthavong Y; Chaiyen P; Diederich F
J Med Chem; 2015 Apr; 58(7):3117-30. PubMed ID: 25785478
[TBL] [Abstract][Full Text] [Related]
18. Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
Mayoka G; Njoroge M; Okombo J; Gibhard L; Sanches-Vaz M; Fontinha D; Birkholtz LM; Reader J; van der Watt M; Coetzer TL; Lauterbach S; Churchyard A; Bezuidenhout B; Egan TJ; Yeates C; Wittlin S; Prudêncio M; Chibale K
J Med Chem; 2019 Jan; 62(2):1022-1035. PubMed ID: 30562027
[TBL] [Abstract][Full Text] [Related]
19. Discovery and optimisation studies of antimalarial phenotypic hits.
Mital A; Murugesan D; Kaiser M; Yeates C; Gilbert IH
Eur J Med Chem; 2015 Oct; 103():530-8. PubMed ID: 26408453
[TBL] [Abstract][Full Text] [Related]
20. Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.
McConville M; Fernández J; Angulo-Barturen Í; Bahamontes-Rosa N; Ballell-Pages L; Castañeda P; de Cózar C; Crespo B; Guijarro L; Jiménez-Díaz MB; Martínez-Martínez MS; de Mercado J; Santos-Villarejo Á; Sanz LM; Frigerio M; Washbourn G; Ward SA; Nixon GL; Biagini GA; Berry NG; Blackman MJ; Calderón F; O'Neill PM
J Med Chem; 2015 Aug; 58(16):6448-55. PubMed ID: 26222445
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
