BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

103 related articles for article (PubMed ID: 25016091)

  • 1. The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: possible role of metalloproteinases.
    Alcántara-Hernández R; Hernández-Méndez A; García-Sáinz JA
    Eur J Pharmacol; 2014 Oct; 740():88-96. PubMed ID: 25016091
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Roles of phosphoinositide-dependent kinase-1 in α1B-adrenoceptor phosphorylation and desensitization.
    Alcántara Hernández R; García-Sáinz JA
    Eur J Pharmacol; 2012 Jan; 674(2-3):179-87. PubMed ID: 22134004
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.
    Komander D; Kular GS; Bain J; Elliott M; Alessi DR; Van Aalten DM
    Biochem J; 2003 Oct; 375(Pt 2):255-62. PubMed ID: 12892559
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase.
    Porchia LM; Guerra M; Wang YC; Zhang Y; Espinosa AV; Shinohara M; Kulp SK; Kirschner LS; Saji M; Chen CS; Ringel MD
    Mol Pharmacol; 2007 Nov; 72(5):1124-31. PubMed ID: 17673571
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).
    Sato S; Fujita N; Tsuruo T
    Oncogene; 2002 Mar; 21(11):1727-38. PubMed ID: 11896604
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules.
    Baxter BK; DiDone L; Ogu D; Schor S; Krysan DJ
    ACS Chem Biol; 2011 May; 6(5):502-10. PubMed ID: 21294551
    [TBL] [Abstract][Full Text] [Related]  

  • 7. For a PDK1 inhibitor, the substrate matters.
    Knight ZA
    Biochem J; 2011 Jan; 433(2):e1-2. PubMed ID: 21175429
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
    Najafov A; Sommer EM; Axten JM; Deyoung MP; Alessi DR
    Biochem J; 2011 Jan; 433(2):357-69. PubMed ID: 21087210
    [TBL] [Abstract][Full Text] [Related]  

  • 9. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway.
    Facchinetti MM; De Siervi A; Toskos D; Senderowicz AM
    Cancer Res; 2004 May; 64(10):3629-37. PubMed ID: 15150122
    [TBL] [Abstract][Full Text] [Related]  

  • 10. G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.
    Akiyama T; Yoshida T; Tsujita T; Shimizu M; Mizukami T; Okabe M; Akinaga S
    Cancer Res; 1997 Apr; 57(8):1495-501. PubMed ID: 9108451
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The phosphoinositide-dependent kinase-1 inhibitor 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) prevents Y-box binding protein-1 from inducing epidermal growth factor receptor.
    To K; Zhao Y; Jiang H; Hu K; Wang M; Wu J; Lee C; Yokom DW; Stratford AL; Klinge U; Mertens PR; Chen CS; Bally M; Yapp D; Dunn SE
    Mol Pharmacol; 2007 Sep; 72(3):641-52. PubMed ID: 17595327
    [TBL] [Abstract][Full Text] [Related]  

  • 12. OSU-03012 in the treatment of glioblastoma.
    McCubrey JA; Lahair MM; Franklin RA
    Mol Pharmacol; 2006 Aug; 70(2):437-9. PubMed ID: 16675657
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Celecoxib enhances the radiosensitizing effect of 7-hydroxystaurosporine (UCN-01) in human lung cancer cell lines.
    Kim YM; Jeong IH; Pyo H
    Int J Radiat Oncol Biol Phys; 2012 Jul; 83(3):e399-407. PubMed ID: 22417802
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Survival-signaling pathway as a promising target for cancer chemotherapy.
    Fujita N; Tsuruo T
    Cancer Chemother Pharmacol; 2003 Jul; 52 Suppl 1():S24-8. PubMed ID: 12819931
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors.
    Chen T; Sorna V; Choi S; Call L; Bearss J; Carpenter K; Warner SL; Sharma S; Bearss DJ; Vankayalapati H
    Bioorg Med Chem Lett; 2017 Dec; 27(24):5473-5480. PubMed ID: 29150397
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor.
    Tseng PH; Wang YC; Weng SC; Weng JR; Chen CS; Brueggemeier RW; Shapiro CL; Chen CY; Dunn SE; Pollak M; Chen CS
    Mol Pharmacol; 2006 Nov; 70(5):1534-41. PubMed ID: 16887935
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).
    Sugiyama K; Akiyama T; Shimizu M; Tamaoki T; Courage C; Gescher A; Akinaga S
    Cancer Res; 1999 Sep; 59(17):4406-12. PubMed ID: 10485490
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport.
    Kondapaka SB; Zarnowski M; Yver DR; Sausville EA; Cushman SW
    Clin Cancer Res; 2004 Nov; 10(21):7192-8. PubMed ID: 15534092
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
    Medina JR; Becker CJ; Blackledge CW; Duquenne C; Feng Y; Grant SW; Heerding D; Li WH; Miller WH; Romeril SP; Scherzer D; Shu A; Bobko MA; Chadderton AR; Dumble M; Gardiner CM; Gilbert S; Liu Q; Rabindran SK; Sudakin V; Xiang H; Brady PG; Campobasso N; Ward P; Axten JM
    J Med Chem; 2011 Mar; 54(6):1871-95. PubMed ID: 21341675
    [TBL] [Abstract][Full Text] [Related]  

  • 20. UCN-01 (7-hydroxystaurosporine) induces apoptosis and G1 arrest of both primary and metastatic oral cancer cell lines in vitro.
    Otsubo A; Bhawal UK; Nomura Y; Mitani Y; Ozawa K; Kuniyasu H; Sugiyama M
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar; 103(3):391-7. PubMed ID: 17321452
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.