BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 25016157)

  • 1. Synthesis and σ receptor affinity of regioisomeric spirocyclic furopyridines.
    Miyata K; Schepmann D; Wünsch B
    Eur J Med Chem; 2014 Aug; 83():709-16. PubMed ID: 25016157
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pyridine analogues of spirocyclic σ₁ receptor ligands.
    Miyata K; Möller G; Schepmann D; Wünsch B
    Bioorg Med Chem; 2014 Aug; 22(15):4277-84. PubMed ID: 24913984
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pd-catalyzed direct C-H bond functionalization of spirocyclic σ1 ligands: generation of a pharmacophore model and analysis of the reverse binding mode by docking into a 3D homology model of the σ1 receptor.
    Meyer C; Schepmann D; Yanagisawa S; Yamaguchi J; Dal Col V; Laurini E; Itami K; Pricl S; Wünsch B
    J Med Chem; 2012 Sep; 55(18):8047-65. PubMed ID: 22913577
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance.
    Jasper A; Schepmann D; Lehmkuhl K; Vela JM; Buschmann H; Holenz J; Wünsch B
    Eur J Med Chem; 2012 Jul; 53():327-36. PubMed ID: 22578786
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability.
    Grosse Maestrup E; Wiese C; Schepmann D; Hiller A; Fischer S; Scheunemann M; Brust P; Wünsch B
    Bioorg Med Chem; 2009 May; 17(10):3630-41. PubMed ID: 19394833
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.
    Jasper A; Schepmann D; Lehmkuhl K; Vela JM; Buschmann H; Holenz J; Wünsch B
    Eur J Med Chem; 2009 Nov; 44(11):4306-14. PubMed ID: 19709783
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity.
    Oberdorf C; Schepmann D; Vela JM; Buschmann H; Holenz J; Wünsch B
    J Med Chem; 2012 Jun; 55(11):5350-60. PubMed ID: 22515405
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans].
    Oberdorf C; Schepmann D; Vela JM; Diaz JL; Holenz J; Wünsch B
    J Med Chem; 2008 Oct; 51(20):6531-7. PubMed ID: 18816044
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1.
    Maier CA; Wünsch B
    J Med Chem; 2002 Jan; 45(2):438-48. PubMed ID: 11784148
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.
    Schläger T; Schepmann D; Würthwein EU; Wünsch B
    Bioorg Med Chem; 2008 Mar; 16(6):2992-3001. PubMed ID: 18221879
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands.
    Huang Y; Hammond PS; Whirrett BR; Kuhner RJ; Wu L; Childers SR; Mach RH
    J Med Chem; 1998 Jun; 41(13):2361-70. PubMed ID: 9632369
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands.
    Moussa IA; Banister SD; Beinat C; Giboureau N; Reynolds AJ; Kassiou M
    J Med Chem; 2010 Aug; 53(16):6228-39. PubMed ID: 20662542
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Oxa-Pictet-Spengler reaction as key step in the synthesis of novel σ receptor ligands with 2-benzopyran structure.
    Knappmann I; Schepmann D; Wünsch B
    Bioorg Med Chem; 2016 Sep; 24(18):4045-4055. PubMed ID: 27396684
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones.
    Meyer C; Neue B; Schepmann D; Yanagisawa S; Yamaguchi J; Würthwein EU; Itami K; Wünsch B
    Bioorg Med Chem; 2013 Apr; 21(7):1844-56. PubMed ID: 23462714
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3.
    Maier CA; Wünsch B
    J Med Chem; 2002 Oct; 45(22):4923-30. PubMed ID: 12383018
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers.
    Bergkemper M; Schepmann D; Wünsch B
    ChemMedChem; 2021 Apr; 16(7):1184-1197. PubMed ID: 33332704
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.
    Bergkemper M; Kronenberg E; Thum S; Börgel F; Daniliuc C; Schepmann D; Nieto FR; Brust P; Reinoso RF; Alvarez I; Wünsch B
    J Med Chem; 2018 Nov; 61(21):9666-9690. PubMed ID: 30350997
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging.
    Li Y; Wang X; Zhang J; Deuther-Conrad W; Xie F; Zhang X; Liu J; Qiao J; Cui M; Steinbach J; Brust P; Liu B; Jia H
    J Med Chem; 2013 May; 56(9):3478-91. PubMed ID: 23566245
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands.
    Zampieri D; Laurini E; Vio L; Golob S; Fermeglia M; Pricl S; Mamolo MG
    Bioorg Med Chem Lett; 2014 Feb; 24(4):1021-5. PubMed ID: 24486131
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ(1) receptor ligands with a (2-fluoroethyl) residue in 3-position.
    Maestrup EG; Wiese C; Schepmann D; Brust P; Wünsch B
    Bioorg Med Chem; 2011 Jan; 19(1):393-405. PubMed ID: 21126878
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.