These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 25016230)

  • 1. Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.
    Coxon FP; Joachimiak L; Najumudeen AK; Breen G; Gmach J; Oetken-Lindholm C; Way R; Dunford JE; Abankwa D; Błażewska KM
    Eur J Med Chem; 2014 Sep; 84():77-89. PubMed ID: 25016230
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and Biological Evaluation of Imidazole-Bearing α-Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT).
    Joachimiak Ł; Marchwicka A; Gendaszewska-Darmach E; Błażewska KM
    ChemMedChem; 2018 Apr; 13(8):842-851. PubMed ID: 29498238
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors.
    Kaźmierczak A; Kusy D; Niinivehmas SP; Gmach J; Joachimiak Ł; Pentikäinen OT; Gendaszewska-Darmach E; Błażewska KM
    J Med Chem; 2017 Nov; 60(21):8781-8800. PubMed ID: 28953373
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates.
    Coxon FP; Taylor A; Stewart CA; Baron R; Seabra MC; Ebetino FH; Rogers MJ
    Bone; 2011 Jul; 49(1):111-21. PubMed ID: 21419243
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.
    Baron RA; Tavaré R; Figueiredo AC; Błazewska KM; Kashemirov BA; McKenna CE; Ebetino FH; Taylor A; Rogers MJ; Coxon FP; Seabra MC
    J Biol Chem; 2009 Mar; 284(11):6861-8. PubMed ID: 19074143
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.
    McKenna CE; Kashemirov BA; Błazewska KM; Mallard-Favier I; Stewart CA; Rojas J; Lundy MW; Ebetino FH; Baron RA; Dunford JE; Kirsten ML; Seabra MC; Bala JL; Marma MS; Rogers MJ; Coxon FP
    J Med Chem; 2010 May; 53(9):3454-64. PubMed ID: 20394422
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors.
    Błażewska KM; Ni F; Haiges R; Kashemirov BA; Coxon FP; Stewart CA; Baron R; Rogers MJ; Seabra MC; Ebetino FH; McKenna CE
    Eur J Med Chem; 2011 Oct; 46(10):4820-6. PubMed ID: 21889236
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo.
    Coxon FP; Ebetino FH; Mules EH; Seabra MC; McKenna CE; Rogers MJ
    Bone; 2005 Sep; 37(3):349-58. PubMed ID: 16006204
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase.
    Małolepsza J; Marchwicka A; Serwa RA; Niinivehmas SP; Pentikäinen OT; Gendaszewska-Darmach E; Błażewska KM
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):940-951. PubMed ID: 35354390
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Applying the prodrug strategy to α-phosphonocarboxylate inhibitors of Rab GGTase--synthesis and stability studies.
    Joachimiak Ł; Janczewski Ł; Ciekot J; Boratyński J; Błażewska K
    Org Biomol Chem; 2015 Jun; 13(24):6844-56. PubMed ID: 26018626
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.
    Tan KT; Guiu-Rozas E; Bon RS; Guo Z; Delon C; Wetzel S; Arndt S; Alexandrov K; Waldmann H; Goody RS; Wu YW; Blankenfeldt W
    J Med Chem; 2009 Dec; 52(24):8025-37. PubMed ID: 19894725
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.
    Temple KJ; Wright EN; Fierke CA; Gibbs RA
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3499-502. PubMed ID: 27342750
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase.
    Holstein SA; Cermak DM; Wiemer DF; Lewis K; Hohl RJ
    Bioorg Med Chem; 1998 Jun; 6(6):687-94. PubMed ID: 9681134
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.
    Baron RA; Seabra MC
    Biochem J; 2008 Oct; 415(1):67-75. PubMed ID: 18532927
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.
    Deraeve C; Guo Z; Bon RS; Blankenfeldt W; DiLucrezia R; Wolf A; Menninger S; Stigter EA; Wetzel S; Choidas A; Alexandrov K; Waldmann H; Goody RS; Wu YW
    J Am Chem Soc; 2012 May; 134(17):7384-91. PubMed ID: 22480322
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.
    Watanabe M; Fiji HD; Guo L; Chan L; Kinderman SS; Slamon DJ; Kwon O; Tamanoi F
    J Biol Chem; 2008 Apr; 283(15):9571-9. PubMed ID: 18230616
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.
    Coxon FP; Helfrich MH; Larijani B; Muzylak M; Dunford JE; Marshall D; McKinnon AD; Nesbitt SA; Horton MA; Seabra MC; Ebetino FH; Rogers MJ
    J Biol Chem; 2001 Dec; 276(51):48213-22. PubMed ID: 11581260
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.
    Leung KF; Baron R; Seabra MC
    J Lipid Res; 2006 Mar; 47(3):467-75. PubMed ID: 16401880
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase.
    Minutolo F; Asso V; Bertini S; Betti L; Gervasi G; Ghilardi E; Giannaccini G; Placanica G; Prota G; Rapposelli S; Macchia M
    Farmaco; 2004 Nov; 59(11):857-61. PubMed ID: 15544789
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids.
    Hohl RJ; Lewis KA; Cermak DM; Wiemer DF
    Lipids; 1998 Jan; 33(1):39-46. PubMed ID: 9470172
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.