BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

202 related articles for article (PubMed ID: 25023329)

  • 1. Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model.
    Van Overbeke W; Verhelle A; Everaert I; Zwaenepoel O; Vandekerckhove J; Cuvelier C; Derave W; Gettemans J
    Mol Ther; 2014 Oct; 22(10):1768-78. PubMed ID: 25023329
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model.
    Van Overbeke W; Wongsantichon J; Everaert I; Verhelle A; Zwaenepoel O; Loonchanta A; Burtnick LD; De Ganck A; Hochepied T; Haigh J; Cuvelier C; Derave W; Robinson RC; Gettemans J
    Hum Mol Genet; 2015 May; 24(9):2492-507. PubMed ID: 25601851
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Non-Invasive Imaging of Amyloid Deposits in a Mouse Model of AGel Using
    Verhelle A; Van Overbeke W; Peleman C; De Smet R; Zwaenepoel O; Lahoutte T; Van Dorpe J; Devoogdt N; Gettemans J
    Mol Imaging Biol; 2016 Dec; 18(6):887-897. PubMed ID: 27130233
    [TBL] [Abstract][Full Text] [Related]  

  • 4. AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model.
    Verhelle A; Nair N; Everaert I; Van Overbeke W; Supply L; Zwaenepoel O; Peleman C; Van Dorpe J; Lahoutte T; Devoogdt N; Derave W; Chuah MK; VandenDriessche T; Gettemans J
    Hum Mol Genet; 2017 Apr; 26(7):1353-1364. PubMed ID: 28334940
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant.
    Giorgino T; Mattioni D; Hassan A; Milani M; Mastrangelo E; Barbiroli A; Verhelle A; Gettemans J; Barzago MM; Diomede L; de Rosa M
    Biochim Biophys Acta Mol Basis Dis; 2019 Mar; 1865(3):648-660. PubMed ID: 30625383
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic.
    Solomon JP; Yonemoto IT; Murray AN; Price JL; Powers ET; Balch WE; Kelly JW
    Biochemistry; 2009 Dec; 48(48):11370-80. PubMed ID: 19904968
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention.
    Solomon JP; Page LJ; Balch WE; Kelly JW
    Crit Rev Biochem Mol Biol; 2012; 47(3):282-96. PubMed ID: 22360545
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Metalloendoprotease cleavage triggers gelsolin amyloidogenesis.
    Page LJ; Suk JY; Huff ME; Lim HJ; Venable J; Yates J; Kelly JW; Balch WE
    EMBO J; 2005 Dec; 24(23):4124-32. PubMed ID: 16281052
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins.
    Page LJ; Suk JY; Bazhenova L; Fleming SM; Wood M; Jiang Y; Guo LT; Mizisin AP; Kisilevsky R; Shelton GD; Balch WE; Kelly JW
    Proc Natl Acad Sci U S A; 2009 Jul; 106(27):11125-30. PubMed ID: 19549824
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rational Design of a Peptidomimetic Inhibitor of Gelsolin Amyloid Aggregation.
    Bollati M; Peqini K; Barone L; Natale C; Beeg M; Gobbi M; Diomede L; Trucchi M; de Rosa M; Pellegrino S
    Int J Mol Sci; 2022 Nov; 23(22):. PubMed ID: 36430461
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Ca2+ binding protects against gelsolin amyloidosis.
    Page LJ; Huff ME; Kelly JW; Balch WE
    Biochem Biophys Res Commun; 2004 Oct; 322(4):1105-10. PubMed ID: 15336957
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type.
    Huff ME; Page LJ; Balch WE; Kelly JW
    J Mol Biol; 2003 Nov; 334(1):119-27. PubMed ID: 14596804
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The amyloidogenicity of gelsolin is controlled by proteolysis and pH.
    Ratnaswamy G; Koepf E; Bekele H; Yin H; Kelly JW
    Chem Biol; 1999 May; 6(5):293-304. PubMed ID: 10322122
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization.
    Chen CD; Huff ME; Matteson J; Page L; Phillips R; Kelly JW; Balch WE
    EMBO J; 2001 Nov; 20(22):6277-87. PubMed ID: 11707399
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pathological and functional amyloid formation orchestrated by the secretory pathway.
    Huff ME; Balch WE; Kelly JW
    Curr Opin Struct Biol; 2003 Dec; 13(6):674-82. PubMed ID: 14675544
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Fibrillogenesis in gelsolin-related familial amyloidosis.
    Maury CP; Nurmiaho-Lassila EL; Boysen G; Liljeström M
    Amyloid; 2003 Aug; 10 Suppl 1():21-5. PubMed ID: 14640038
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of proprotein convertases in the pathogenic processing of the amyloidosis-associated form of secretory gelsolin.
    Kangas H; Seidah NG; Paunio T
    Amyloid; 2002 Jun; 9(2):83-7. PubMed ID: 12440480
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Danish type gelsolin related amyloidosis: 654G-T mutation is associated with a disease pathogenetically and clinically similar to that caused by the 654G-A mutation (familial amyloidosis of the Finnish type).
    Maury CP; Liljeström M; Boysen G; Törnroth T; de la Chapelle A; Nurmiaho-Lassila EL
    J Clin Pathol; 2000 Feb; 53(2):95-9. PubMed ID: 10767822
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type.
    Kazmirski SL; Isaacson RL; An C; Buckle A; Johnson CM; Daggett V; Fersht AR
    Nat Struct Biol; 2002 Feb; 9(2):112-6. PubMed ID: 11753432
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension.
    Solomon JP; Bourgault S; Powers ET; Kelly JW
    Biochemistry; 2011 Apr; 50(13):2486-98. PubMed ID: 21348501
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.