157 related articles for article (PubMed ID: 25037914)
1. Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition.
Hanke T; Lamers C; Gomez RC; Schneider G; Werz O; Schubert-Zsilavecz M
Bioorg Med Chem Lett; 2014 Aug; 24(16):3757-63. PubMed ID: 25037914
[TBL] [Abstract][Full Text] [Related]
2. Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Hanke T; Dehm F; Liening S; Popella SD; Maczewsky J; Pillong M; Kunze J; Weinigel C; Barz D; Kaiser A; Wurglics M; Lämmerhofer M; Schneider G; Sautebin L; Schubert-Zsilavecz M; Werz O
J Med Chem; 2013 Nov; 56(22):9031-44. PubMed ID: 24171493
[TBL] [Abstract][Full Text] [Related]
3. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A; Zettl H; Greiner C; Wurglics M; Schubert-Zsilavecz M; Werz O
J Med Chem; 2008 Dec; 51(24):8068-76. PubMed ID: 19053751
[TBL] [Abstract][Full Text] [Related]
4. A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.
Hieke M; Greiner C; Thieme TM; Schubert-Zsilavecz M; Werz O; Zettl H
Bioorg Med Chem Lett; 2011 Mar; 21(5):1329-33. PubMed ID: 21310608
[TBL] [Abstract][Full Text] [Related]
5. Quinoline-based derivatives of pirinixic acid as dual PPAR alpha/gamma agonists.
Popescu L; Rau O; Böttcher J; Syha Y; Schubert-Zsilavecz M
Arch Pharm (Weinheim); 2007 Jul; 340(7):367-71. PubMed ID: 17610302
[TBL] [Abstract][Full Text] [Related]
6. Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.
Greiner C; Zettl H; Koeberle A; Pergola C; Northoff H; Schubert-Zsilavecz M; Werz O
Bioorg Med Chem; 2011 Jun; 19(11):3394-401. PubMed ID: 21570310
[TBL] [Abstract][Full Text] [Related]
7. Molecular determinants for improved activity at PPARα: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα.
Lamers C; Dittrich M; Steri R; Proschak E; Schubert-Zsilavecz M
Bioorg Med Chem Lett; 2014 Aug; 24(16):4048-52. PubMed ID: 25022880
[TBL] [Abstract][Full Text] [Related]
8. The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A; Rossi A; Zettl H; Pergola C; Dehm F; Bauer J; Greiner C; Reckel S; Hoernig C; Northoff H; Bernhard F; Dötsch V; Sautebin L; Schubert-Zsilavecz M; Werz O
J Pharmacol Exp Ther; 2010 Mar; 332(3):840-8. PubMed ID: 19934399
[TBL] [Abstract][Full Text] [Related]
9. Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
Schaible AM; Traber H; Temml V; Noha SM; Filosa R; Peduto A; Weinigel C; Barz D; Schuster D; Werz O
Biochem Pharmacol; 2013 Aug; 86(4):476-86. PubMed ID: 23623753
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.
Wiechmann K; Müller H; Huch V; Hartmann D; Werz O; Jauch J
Eur J Med Chem; 2015 Aug; 101():133-49. PubMed ID: 26123643
[TBL] [Abstract][Full Text] [Related]
11. Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.
Hieke M; Greiner C; Dittrich M; Reisen F; Schneider G; Schubert-Zsilavecz M; Werz O
J Med Chem; 2011 Jul; 54(13):4490-507. PubMed ID: 21591611
[TBL] [Abstract][Full Text] [Related]
12. Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.
Rau O; Syha Y; Zettl H; Kock M; Bock A; Schubert-Zsilavecz M
Arch Pharm (Weinheim); 2008 Mar; 341(3):191-5. PubMed ID: 18275039
[TBL] [Abstract][Full Text] [Related]
13. Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.
Thieme TM; Steri R; Proschak E; Paulke A; Schneider G; Schubert-Zsilavecz M
Bioorg Med Chem Lett; 2010 Apr; 20(8):2469-73. PubMed ID: 20307981
[TBL] [Abstract][Full Text] [Related]
14. Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1.
Napagoda M; Gerstmeier J; Koeberle A; Wesely S; Popella S; Lorenz S; Scheubert K; Böcker S; Svatoš A; Werz O
J Ethnopharmacol; 2014 Feb; 151(2):882-90. PubMed ID: 24315851
[TBL] [Abstract][Full Text] [Related]
15. Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.
Chini MG; De Simone R; Bruno I; Riccio R; Dehm F; Weinigel C; Barz D; Werz O; Bifulco G
Eur J Med Chem; 2012 Aug; 54():311-23. PubMed ID: 22683242
[TBL] [Abstract][Full Text] [Related]
16. Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy.
Gürses T; Olğaç A; Garscha U; Gür Maz T; Bal NB; Uludağ O; Çalışkan B; Schubert US; Werz O; Banoglu E
Bioorg Chem; 2021 Jul; 112():104861. PubMed ID: 33826984
[TBL] [Abstract][Full Text] [Related]
17. Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.
De Simone R; Bruno I; Riccio R; Stadler K; Bauer J; Schaible AM; Laufer S; Werz O
Bioorg Med Chem; 2012 Aug; 20(16):5012-6. PubMed ID: 22795900
[TBL] [Abstract][Full Text] [Related]
18. Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).
Liedtke AJ; Keck PR; Lehmann F; Koeberle A; Werz O; Laufer SA
J Med Chem; 2009 Aug; 52(15):4968-72. PubMed ID: 19719242
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.
Hanke T; Rörsch F; Thieme TM; Ferreiros N; Schneider G; Geisslinger G; Proschak E; Grösch S; Schubert-Zsilavecz M
Bioorg Med Chem; 2013 Dec; 21(24):7874-83. PubMed ID: 24183739
[TBL] [Abstract][Full Text] [Related]
20. Pirinixic acids: flexible fatty acid mimetics with various biological activities.
Merk D; Zettl M; Steinhilber D; Werz O; Schubert-Zsilavecz M
Future Med Chem; 2015 Aug; 7(12):1597-616. PubMed ID: 26313377
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
