BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

237 related articles for article (PubMed ID: 25041251)

  • 1. Erythropoietin increases bioavailability of tetrahydrobiopterin and protects cerebral microvasculature against oxidative stress induced by eNOS uncoupling.
    Santhanam AV; d'Uscio LV; Katusic ZS
    J Neurochem; 2014 Nov; 131(4):521-9. PubMed ID: 25041251
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Erythropoietin prevents endothelial dysfunction in GTP-cyclohydrolase I-deficient hph1 mice.
    dʼUscio LV; Santhanam AV; Katusic ZS
    J Cardiovasc Pharmacol; 2014 Dec; 64(6):514-21. PubMed ID: 25490417
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice.
    Santhanam AV; d'Uscio LV; He T; Das P; Younkin SG; Katusic ZS
    J Neurochem; 2015 Sep; 134(6):1129-38. PubMed ID: 26111938
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase I.
    Santhanam AV; d'Uscio LV; Katusic ZS
    Brain Res; 2015 Nov; 1625():198-205. PubMed ID: 26343845
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice.
    Santhanam AV; d'Uscio LV; He T; Katusic ZS
    Brain Res; 2012 Nov; 1483():89-95. PubMed ID: 22982594
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
    Crabtree MJ; Tatham AL; Hale AB; Alp NJ; Channon KM
    J Biol Chem; 2009 Oct; 284(41):28128-28136. PubMed ID: 19666465
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
    Crabtree MJ; Tatham AL; Al-Wakeel Y; Warrick N; Hale AB; Cai S; Channon KM; Alp NJ
    J Biol Chem; 2009 Jan; 284(2):1136-44. PubMed ID: 19011239
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
    Crabtree MJ; Hale AB; Channon KM
    Free Radic Biol Med; 2011 Jun; 50(11):1639-46. PubMed ID: 21402147
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.
    Schmidt K; Kolesnik B; Gorren AC; Werner ER; Mayer B
    Biochem Pharmacol; 2014 Aug; 90(3):246-53. PubMed ID: 24863258
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
    Benson MA; Batchelor H; Chuaiphichai S; Bailey J; Zhu H; Stuehr DJ; Bhattacharya S; Channon KM; Crabtree MJ
    J Biol Chem; 2013 Oct; 288(41):29836-45. PubMed ID: 23965989
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.
    Sugiyama T; Levy BD; Michel T
    J Biol Chem; 2009 May; 284(19):12691-700. PubMed ID: 19286667
    [TBL] [Abstract][Full Text] [Related]  

  • 12. GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.
    Xie HH; Zhou S; Chen DD; Channon KM; Su DF; Chen AF
    Hypertension; 2010 Dec; 56(6):1137-44. PubMed ID: 21059996
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice.
    Santhanam AV; d'Uscio LV; Smith LA; Katusic ZS
    J Neurochem; 2012 Sep; 122(6):1211-8. PubMed ID: 22784235
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Computational analysis of interactions of oxidative stress and tetrahydrobiopterin reveals instability in eNOS coupling.
    Joshi S; Kar S; Kavdia M
    Microvasc Res; 2017 Nov; 114():114-128. PubMed ID: 28729163
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
    Chuaiphichai S; Crabtree MJ; Mcneill E; Hale AB; Trelfa L; Channon KM; Douglas G
    Br J Pharmacol; 2017 Apr; 174(8):657-671. PubMed ID: 28128438
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
    Crabtree MJ; Brixey R; Batchelor H; Hale AB; Channon KM
    J Biol Chem; 2013 Jan; 288(1):561-9. PubMed ID: 23139420
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase.
    Abdelghany TM; Ismail RS; Mansoor FA; Zweier JR; Lowe F; Zweier JL
    Nitric Oxide; 2018 Jun; 76():113-121. PubMed ID: 29524646
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.
    d'Uscio LV; Smith LA; Katusic ZS
    Am J Physiol Heart Circ Physiol; 2011 Dec; 301(6):H2227-34. PubMed ID: 21963838
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
    Bendall JK; Alp NJ; Warrick N; Cai S; Adlam D; Rockett K; Yokoyama M; Kawashima S; Channon KM
    Circ Res; 2005 Oct; 97(9):864-71. PubMed ID: 16179591
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.
    Wang S; Xu J; Song P; Wu Y; Zhang J; Chul Choi H; Zou MH
    Hypertension; 2008 Sep; 52(3):484-90. PubMed ID: 18645049
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.