BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

74 related articles for article (PubMed ID: 25047940)

  • 1. Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.
    Edupuganti R; Wang Q; Tavares CD; Chitjian CA; Bachman JL; Ren P; Anslyn EV; Dalby KN
    Bioorg Med Chem; 2014 Sep; 22(17):4910-6. PubMed ID: 25047940
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy.
    Guan Y; Jiang S; Ye W; Ren X; Wang X; Zhang Y; Yin M; Wang K; Tao Y; Yang J; Cao D; Cheng Y
    Cell Death Dis; 2020 Nov; 11(11):948. PubMed ID: 33144562
    [TBL] [Abstract][Full Text] [Related]  

  • 3. ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin.
    Piserchio A; Long KJ; Browning LS; Bohanon AL; Isiorho EA; Dalby KN; Ghose R
    Proc Natl Acad Sci U S A; 2023 Apr; 120(17):e2300902120. PubMed ID: 37068230
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition.
    Piserchio A; Will N; Giles DH; Hajredini F; Dalby KN; Ghose R
    J Mol Biol; 2019 Jul; 431(15):2700-2717. PubMed ID: 31108082
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Revealing eEF-2 kinase: recent structural insights into function.
    Piserchio A; Dalby KN; Ghose R
    Trends Biochem Sci; 2024 Feb; 49(2):169-182. PubMed ID: 38103971
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, Herbicidal Activity, Mode of Action, and In Silico Analysis of Novel Pyrido[2,3-
    Min L; Liang W; Bajsa-Hirschel J; Ye P; Wang Q; Sun X; Cantrell CL; Han L; Sun N; Duke SO; Liu X
    Molecules; 2023 Oct; 28(21):. PubMed ID: 37959782
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery and development of a small molecule library with lumazine synthase inhibitory activity.
    Talukdar A; Breen M; Bacher A; Illarionov B; Fischer M; Georg G; Ye QZ; Cushman M
    J Org Chem; 2009 Aug; 74(15):5123-34. PubMed ID: 19552377
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and biological evaluation of pyrido[3,2-d]pyrimidine derivatives as novel ATR inhibitors.
    Duan Y; Zhuang L; Xu Y; Cheng H; Xia J; Lu T; Chen Y
    Bioorg Chem; 2023 Jul; 136():106535. PubMed ID: 37086581
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis, anticancer activity and molecular docking of new quinolines, quinazolines and 1,2,4-triazoles with pyrido[2,3-
    Abu-Hashem AA; Hakami O; Amri N
    Heliyon; 2024 Mar; 10(5):e26735. PubMed ID: 38468950
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of novel bioactive pyrido[2,3-
    Tantawy ES; Nafie MS; Morsy HA; El-Sayed HA; Moustafa AH; Mohammed SM
    RSC Adv; 2024 Apr; 14(16):11098-11111. PubMed ID: 38586446
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and cytotoxicity evaluation of novel pyrido[3,4-
    Wei L; Malhotra SV
    Medchemcomm; 2012 Oct; 3(10):1250-1257. PubMed ID: 25429348
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7(8H)-one derivatives as potent USP1 inhibitors.
    Li H; Liu BJ; Xu J; Song SS; Ba R; Zhang J; Huan XJ; Wang D; Miao ZH; Liu T; He JX; Xiong B
    Eur J Med Chem; 2024 Jun; 275():116568. PubMed ID: 38889606
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of a new pyrido[2,3-
    Rosa FA; Gonçalves DS; Pianoski KE; da Silva MJV; Ames FQ; Aguiar RP; Volpato H; Lazarin-Bidóia D; Nakamura CV; Bersani-Amado CA
    RSC Med Chem; 2024 Mar; 15(3):1038-1045. PubMed ID: 38516591
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and cyclometalation of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold.
    Mulcahy SP; Carroll PJ; Meggers E
    Tetrahedron Lett; 2006 Dec; 47(50):8877-8880. PubMed ID: 18071577
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis.
    Wang Q; Edupuganti R; Tavares CD; Dalby KN; Ren P
    Front Mol Biosci; 2015; 2():9. PubMed ID: 25988177
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine.
    Warthaka M; Adelmann CH; Kaoud TS; Edupuganti R; Yan C; Johnson WH; Ferguson S; Tavares CD; Pence LJ; Anslyn EV; Ren P; Tsai KY; Dalby KN
    ACS Med Chem Lett; 2015 Jan; 6(1):47-52. PubMed ID: 25589929
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reversible covalent inhibition of eEF-2K by carbonitriles.
    Devkota AK; Edupuganti R; Yan C; Shi Y; Jose J; Wang Q; Kaoud TS; Cho EJ; Ren P; Dalby KN
    Chembiochem; 2014 Nov; 15(16):2435-42. PubMed ID: 25224652
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
    Piserchio A; Isiorho EA; Dalby KN; Ghose R
    J Biol Chem; 2023 Jun; 299(6):104813. PubMed ID: 37172726
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel etodolac derivatives as eukaryotic elongation factor 2 kinase (eEF2K) inhibitors for targeted cancer therapy.
    Comert Onder F; Siyah P; Durdagi S; Ay M; Ozpolat B
    RSC Med Chem; 2022 Jul; 13(7):840-849. PubMed ID: 35923718
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Irreversible Antagonists for the Adenosine A
    Temirak A; Schlegel JG; Voss JH; Vaaßen VJ; Vielmuth C; Claff T; Müller CE
    Molecules; 2022 Jun; 27(12):. PubMed ID: 35744918
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.