BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

409 related articles for article (PubMed ID: 25056877)

  • 1. REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.
    Dennis MD; Coleman CS; Berg A; Jefferson LS; Kimball SR
    Sci Signal; 2014 Jul; 7(335):ra68. PubMed ID: 25056877
    [TBL] [Abstract][Full Text] [Related]  

  • 2. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).
    Dennis MD; McGhee NK; Jefferson LS; Kimball SR
    Cell Signal; 2013 Dec; 25(12):2709-16. PubMed ID: 24018049
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1.
    Watson A; Lipina C; McArdle HJ; Taylor PM; Hundal HS
    Cell Signal; 2016 May; 28(5):412-424. PubMed ID: 26827808
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.
    Gordon BS; Williamson DL; Lang CH; Jefferson LS; Kimball SR
    J Nutr; 2015 Apr; 145(4):708-13. PubMed ID: 25716553
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).
    Dan HC; Ebbs A; Pasparakis M; Van Dyke T; Basseres DS; Baldwin AS
    J Biol Chem; 2014 Sep; 289(36):25227-40. PubMed ID: 24990947
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.
    Li Y; Wang X; Yue P; Tao H; Ramalingam SS; Owonikoko TK; Deng X; Wang Y; Fu H; Khuri FR; Sun SY
    J Biol Chem; 2013 May; 288(19):13215-24. PubMed ID: 23536185
    [TBL] [Abstract][Full Text] [Related]  

  • 8. p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
    Cam M; Bid HK; Xiao L; Zambetti GP; Houghton PJ; Cam H
    J Biol Chem; 2014 Feb; 289(7):4083-94. PubMed ID: 24366874
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.
    Williamson DL; Li Z; Tuder RM; Feinstein E; Kimball SR; Dungan CM
    J Appl Physiol (1985); 2014 Aug; 117(3):246-56. PubMed ID: 24876363
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle.
    Steiner JL; Crowell KT; Kimball SR; Lang CH
    Am J Physiol Endocrinol Metab; 2015 Dec; 309(12):E981-94. PubMed ID: 26487002
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Renal tumours in a Tsc2(+/-) mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin.
    Yang J; Kalogerou M; Samsel PA; Zhang Y; Griffiths DF; Gallacher J; Sampson JR; Shen MH
    Oncogene; 2015 Feb; 34(7):922-31. PubMed ID: 24632604
    [TBL] [Abstract][Full Text] [Related]  

  • 12. mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A.
    Harwood FC; Shu L; Houghton PJ
    J Biol Chem; 2008 Feb; 283(5):2575-85. PubMed ID: 18056704
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
    Wolff NC; Vega-Rubin-de-Celis S; Xie XJ; Castrillon DH; Kabbani W; Brugarolas J
    Mol Cell Biol; 2011 May; 31(9):1870-84. PubMed ID: 21383064
    [TBL] [Abstract][Full Text] [Related]  

  • 14. CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling.
    Liao WT; Chiang YJ; Yang-Yen HF; Hsu LC; Chang ZF; Yen JJY
    J Biol Chem; 2023 Dec; 299(12):105455. PubMed ID: 37949232
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling.
    Winter JN; Jefferson LS; Kimball SR
    Am J Physiol Cell Physiol; 2011 May; 300(5):C1172-80. PubMed ID: 21289294
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
    Copps KD; Hançer NJ; Qiu W; White MF
    J Biol Chem; 2016 Apr; 291(16):8602-17. PubMed ID: 26846849
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP1.
    Wada R; Fujinuma S; Nakatsumi H; Matsumoto M; Nakayama KI
    J Biochem; 2023 Feb; 173(2):129-138. PubMed ID: 36477205
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction.
    Gordon BS; Steiner JL; Lang CH; Jefferson LS; Kimball SR
    Am J Physiol Endocrinol Metab; 2014 Oct; 307(8):E703-11. PubMed ID: 25159324
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
    Liu Z; Chen X; Wang Y; Peng H; Wang Y; Jing Y; Zhang H
    J Biol Chem; 2014 Oct; 289(43):29739-49. PubMed ID: 25164809
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fisetin regulates obesity by targeting mTORC1 signaling.
    Jung CH; Kim H; Ahn J; Jeon TI; Lee DH; Ha TY
    J Nutr Biochem; 2013 Aug; 24(8):1547-54. PubMed ID: 23517912
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.