BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 25079348)

  • 1. Redesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomography.
    Muthu P; Chen HX; Lutz S
    ACS Chem Biol; 2014 Oct; 9(10):2326-33. PubMed ID: 25079348
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides.
    Sabini E; Hazra S; Konrad M; Lavie A
    J Med Chem; 2007 Jun; 50(13):3004-14. PubMed ID: 17530837
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues .
    Hazra S; Ort S; Konrad M; Lavie A
    Biochemistry; 2010 Aug; 49(31):6784-90. PubMed ID: 20614893
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificity.
    Iyidogan P; Lutz S
    Biochemistry; 2008 Apr; 47(16):4711-20. PubMed ID: 18361501
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.
    Verri A; Priori G; Spadari S; Tondelli L; Focher F
    Biochem J; 1997 Nov; 328 ( Pt 1)(Pt 1):317-20. PubMed ID: 9359870
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy.
    Johnsamuel J; Eriksson S; Oliveira M; Tjarks W
    Bioorg Med Chem; 2005 Jul; 13(13):4160-7. PubMed ID: 15876539
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of residues involved in the substrate specificity of human and murine dCK.
    Usova EV; Eriksson S
    Biochem Pharmacol; 2002 Dec; 64(11):1559-67. PubMed ID: 12429345
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs.
    Likar Y; Zurita J; Dobrenkov K; Shenker L; Cai S; Neschadim A; Medin JA; Sadelain M; Hricak H; Ponomarev V
    J Nucl Med; 2010 Sep; 51(9):1395-403. PubMed ID: 20810757
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel PET probes specific for deoxycytidine kinase.
    Shu CJ; Campbell DO; Lee JT; Tran AQ; Wengrod JC; Witte ON; Phelps ME; Satyamurthy N; Czernin J; Radu CG
    J Nucl Med; 2010 Jul; 51(7):1092-8. PubMed ID: 20554721
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene.
    McCracken MN; Gschweng EH; Nair-Gill E; McLaughlin J; Cooper AR; Riedinger M; Cheng D; Nosala C; Kohn DB; Witte ON
    Proc Natl Acad Sci U S A; 2013 Jan; 110(5):1857-62. PubMed ID: 23319634
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Substrate/inhibitor specificities of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2).
    Kierdaszuk B; Krawiec K; Kazimierczuk Z; Jacobsson U; Johansson NG; Munch-Petersen B; Eriksson S; Shugar D
    Adv Exp Med Biol; 1998; 431():623-7. PubMed ID: 9598140
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fluorescence energy transfer studies of human deoxycytidine kinase: role of cysteine 185 in the conformational changes that occur upon substrate binding.
    Mani RS; Usova EV; Cass CE; Eriksson S
    Biochemistry; 2006 Mar; 45(11):3534-41. PubMed ID: 16533034
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural basis for substrate promiscuity of dCK.
    Sabini E; Hazra S; Ort S; Konrad M; Lavie A
    J Mol Biol; 2008 May; 378(3):607-21. PubMed ID: 18377927
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O'-alkyl analogues.
    Kierdaszuk B; Krawiec K; Kazimierczuk Z; Jacobsson U; Johansson NG; Munch-Petersen B; Eriksson S; Shugar D
    Nucleosides Nucleotides; 1999 Aug; 18(8):1883-903. PubMed ID: 10478487
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.
    Campbell DO; Yaghoubi SS; Su Y; Lee JT; Auerbach MS; Herschman H; Satyamurthy N; Czernin J; Lavie A; Radu CG
    J Biol Chem; 2012 Jan; 287(1):446-454. PubMed ID: 22074768
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase.
    Sabini E; Hazra S; Konrad M; Burley SK; Lavie A
    Nucleic Acids Res; 2007; 35(1):186-92. PubMed ID: 17158155
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparative Analysis of Human Nucleoside Kinase-Based Reporter Systems for PET Imaging.
    Lee JT; Zhang H; Moroz MA; Likar Y; Shenker L; Sumzin N; Lobo J; Zurita J; Collins J; van Dam RM; Ponomarev V
    Mol Imaging Biol; 2017 Feb; 19(1):100-108. PubMed ID: 27393689
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases.
    Johansson NG; Eriksson S
    Acta Biochim Pol; 1996; 43(1):143-60. PubMed ID: 8790720
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Expression of human mitochondrial thymidine kinase in Escherichia coli: correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth.
    Wang J; Su C; Neuhard J; Eriksson S
    Biochem Pharmacol; 2000 Jun; 59(12):1583-8. PubMed ID: 10799656
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase.
    Sabini E; Hazra S; Konrad M; Lavie A
    J Med Chem; 2008 Jul; 51(14):4219-25. PubMed ID: 18570408
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.