BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

137 related articles for article (PubMed ID: 25082125)

  • 1. Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists.
    Jeon MK; Lee KM; Kim IH; Jang YK; Kang SK; Lee JM; Jung KY; Kumar JA; Rhee SD; Jung WH; Song JS; Bae MA; Kim KR; Ahn JH
    Bioorg Med Chem Lett; 2014 Sep; 24(17):4281-5. PubMed ID: 25082125
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists.
    Kim H; Cho SJ; Yoo M; Kang SK; Kim KR; Lee HH; Song JS; Rhee SD; Jung WH; Ahn JH; Jung JK; Jung KY
    Bioorg Med Chem Lett; 2017 Dec; 27(23):5213-5220. PubMed ID: 29103971
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists.
    Jang YK; Lee KM; Jung KY; Kang SK; Pagire SH; Lee JM; Pagire HS; Kim KR; Bae MA; Lee H; Rhee SD; Ahn JH
    Bioorg Med Chem Lett; 2017 Aug; 27(16):3909-3914. PubMed ID: 28666737
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and structure-activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists.
    Negoro K; Yonetoku Y; Moritomo A; Hayakawa M; Iikubo K; Yoshida S; Takeuchi M; Ohta M
    Bioorg Med Chem; 2012 Nov; 20(21):6442-51. PubMed ID: 23010456
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists.
    Fang Y; Xiong L; Hu J; Zhang S; Xie S; Tu L; Wan Y; Jin Y; Li X; Hu S; Yang Z
    Bioorg Chem; 2019 May; 86():103-111. PubMed ID: 30685641
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists.
    Gillespie P; Goodnow RA; Saha G; Bose G; Moulik K; Zwingelstein C; Myers M; Conde-Knape K; Pietranico-Cole S; So SS
    Bioorg Med Chem Lett; 2014 Feb; 24(3):949-53. PubMed ID: 24412066
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Optimization of a novel series of potent and orally bioavailable GPR119 agonists.
    Koshizawa T; Morimoto T; Watanabe G; Watanabe T; Yamasaki N; Sawada Y; Fukuda T; Okuda A; Shibuya K; Ohgiya T
    Bioorg Med Chem Lett; 2017 Aug; 27(15):3249-3253. PubMed ID: 28648463
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of novel pyrimido[5,4-d]pyrimidine derivatives as GPR119 agonist for treatment of type 2 diabetes.
    Fang Y; Xu J; Li Z; Yang Z; Xiong L; Jin Y; Wang Q; Xie S; Zhu W; Chang S
    Bioorg Med Chem; 2018 Aug; 26(14):4080-4087. PubMed ID: 30100020
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design and synthesis of tetrahydropyridopyrimidine derivatives as dual GPR119 and DPP-4 modulators.
    Fang Y; Zhang S; Wu W; Liu Y; Yang J; Li Y; Li M; Dong H; Jin Y; Liu R; Yang Z
    Bioorg Chem; 2020 Jan; 94():103390. PubMed ID: 31662212
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists.
    Negoro K; Yonetoku Y; Misawa-Mukai H; Hamaguchi W; Maruyama T; Yoshida S; Takeuchi M; Ohta M
    Bioorg Med Chem; 2012 Sep; 20(17):5235-46. PubMed ID: 22836190
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-
    Fang Y; Zhang S; Li M; Xiong L; Tu L; Xie S; Jin Y; Liu Y; Yang Z; Liu R
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):50-58. PubMed ID: 31656107
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion.
    Yoshida S; Ohishi T; Matsui T; Shibasaki M
    Biochem Biophys Res Commun; 2010 Sep; 400(3):437-41. PubMed ID: 20804735
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design and synthesis of novel and potent GPR119 agonists with a spirocyclic structure.
    Harada K; Mizukami J; Kadowaki S; Matsuda I; Watanabe T; Oe Y; Kodama Y; Aoki K; Suwa K; Fukuda S; Yata S; Inaba T
    Bioorg Med Chem Lett; 2018 Apr; 28(7):1228-1233. PubMed ID: 29519733
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists.
    Dai X; Stamford A; Liu H; Neustadt B; Hao J; Kowalski T; Hawes B; Xu X; Baker H; O'Neill K; Woods M; Tang H; Greenlee W
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5291-4. PubMed ID: 26433449
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological evaluation of 5-nitropyrimidine analogs with azabicyclic substituents as GPR119 agonists.
    Yang Z; Fang Y; Pham TA; Lee J; Park H
    Bioorg Med Chem Lett; 2013 Mar; 23(5):1519-21. PubMed ID: 23374864
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists.
    Matsuda D; Kawamura M; Kobashi Y; Shiozawa F; Suga Y; Fusegi K; Nishimoto S; Kimura K; Miyoshi M; Takayama N; Kakinuma H; Ohtake N
    Bioorg Med Chem; 2018 May; 26(8):1832-1847. PubMed ID: 29486951
    [TBL] [Abstract][Full Text] [Related]  

  • 17. β-Cell Inactivation of
    Panaro BL; Flock GB; Campbell JE; Beaudry JL; Cao X; Drucker DJ
    Diabetes; 2017 Jun; 66(6):1626-1635. PubMed ID: 28254842
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice.
    Moran BM; Abdel-Wahab YH; Flatt PR; McKillop AM
    Biol Chem; 2014 Apr; 395(4):453-64. PubMed ID: 24323890
    [TBL] [Abstract][Full Text] [Related]  

  • 19. AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes.
    Yoshida S; Tanaka H; Oshima H; Yamazaki T; Yonetoku Y; Ohishi T; Matsui T; Shibasaki M
    Biochem Biophys Res Commun; 2010 Oct; 400(4):745-51. PubMed ID: 20816753
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists.
    Fang Y; Yang Z; Gundeti S; Lee J; Park H
    Bioorg Med Chem; 2017 Jan; 25(1):254-260. PubMed ID: 27825553
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.