BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

460 related articles for article (PubMed ID: 25082512)

  • 1. Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.
    Li Y; Peng P; Tang L; Hu Y; Hu Y; Sheng R
    Bioorg Med Chem; 2014 Sep; 22(17):4717-25. PubMed ID: 25082512
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer's Disease.
    Yu YF; Huang YD; Zhang C; Wu XN; Zhou Q; Wu D; Wu Y; Luo HB
    ACS Chem Neurosci; 2017 Nov; 8(11):2522-2534. PubMed ID: 28783948
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.
    Yan J; Hu J; Liu A; He L; Li X; Wei H
    Bioorg Med Chem; 2017 Jun; 25(12):2946-2955. PubMed ID: 28454848
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.
    Jameel E; Meena P; Maqbool M; Kumar J; Ahmed W; Mumtazuddin S; Tiwari M; Hoda N; Jayaram B
    Eur J Med Chem; 2017 Aug; 136():36-51. PubMed ID: 28478343
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.
    Luo W; Su YB; Hong C; Tian RG; Su LP; Wang YQ; Li Y; Yue JJ; Wang CJ
    Bioorg Med Chem; 2013 Dec; 21(23):7275-82. PubMed ID: 24148835
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
    Thiratmatrakul S; Yenjai C; Waiwut P; Vajragupta O; Reubroycharoen P; Tohda M; Boonyarat C
    Eur J Med Chem; 2014 Mar; 75():21-30. PubMed ID: 24508831
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
    Ma F; Du H
    Eur J Med Chem; 2017 Nov; 140():118-127. PubMed ID: 28923380
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Lan JS; Xie SS; Li SY; Pan LF; Wang XB; Kong LY
    Bioorg Med Chem; 2014 Nov; 22(21):6089-104. PubMed ID: 25282654
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.
    Manral A; Saini V; Meena P; Tiwari M
    Bioorg Med Chem; 2015 Oct; 23(19):6389-403. PubMed ID: 26337018
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.
    Meena P; Nemaysh V; Khatri M; Manral A; Luthra PM; Tiwari M
    Bioorg Med Chem; 2015 Mar; 23(5):1135-48. PubMed ID: 25624107
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
    Xie SS; Wang XB; Li JY; Yang L; Kong LY
    Eur J Med Chem; 2013 Jun; 64():540-53. PubMed ID: 23685572
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    Sang Z; Wang K; Shi J; Liu W; Tan Z
    Eur J Med Chem; 2019 Sep; 178():726-739. PubMed ID: 31229875
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.
    Li RS; Wang XB; Hu XJ; Kong LY
    Bioorg Med Chem Lett; 2013 May; 23(9):2636-41. PubMed ID: 23511019
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Xiao G; Li Y; Qiang X; Xu R; Zheng Y; Cao Z; Luo L; Yang X; Sang Z; Su F; Deng Y
    Bioorg Med Chem; 2017 Feb; 25(3):1030-1041. PubMed ID: 28011206
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.
    Kurt BZ; Gazioglu I; Basile L; Sonmez F; Ginex T; Kucukislamoglu M; Guccione S
    Eur J Med Chem; 2015 Sep; 102():80-92. PubMed ID: 26244990
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.
    Roy KK; Tota S; Tripathi T; Chander S; Nath C; Saxena AK
    Bioorg Med Chem; 2012 Nov; 20(21):6313-20. PubMed ID: 23026084
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.
    Liu HR; Liu XJ; Fan HQ; Tang JJ; Gao XH; Liu WK
    Bioorg Med Chem; 2014 Nov; 22(21):6124-33. PubMed ID: 25260958
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
    Huang L; Miao H; Sun Y; Meng F; Li X
    Eur J Med Chem; 2014 Nov; 87():429-39. PubMed ID: 25282266
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
    Xu A; He F; Zhang X; Li X; Ran Y; Wei C; James Chou C; Zhang R; Wu J
    Bioorg Chem; 2020 May; 98():103721. PubMed ID: 32193030
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.
    Sheng R; Lin X; Zhang J; Chol KS; Huang W; Yang B; He Q; Hu Y
    Bioorg Med Chem; 2009 Sep; 17(18):6692-8. PubMed ID: 19692250
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.