BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 25084335)

  • 1. Mapping the conformational space accessible to catechol-O-methyltransferase.
    Ehler A; Benz J; Schlatter D; Rudolph MG
    Acta Crystallogr D Biol Crystallogr; 2014 Aug; 70(Pt 8):2163-74. PubMed ID: 25084335
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone.
    Iijima H; Takebe K; Suzuki M; Kobayashi H; Takamiya T; Saito H; Niwa N; Kuwada-Kusunose T
    Chem Pharm Bull (Tokyo); 2020; 68(5):447-451. PubMed ID: 32378542
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structures of the apo and holo form of rat catechol-O-methyltransferase.
    Tsuji E; Okazaki K; Isaji M; Takeda K
    J Struct Biol; 2009 Mar; 165(3):133-9. PubMed ID: 19111934
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors.
    Ellermann M; Paulini R; Jakob-Roetne R; Lerner C; Borroni E; Roth D; Ehler A; Schweizer WB; Schlatter D; Rudolph MG; Diederich F
    Chemistry; 2011 May; 17(23):6369-81. PubMed ID: 21538606
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structures of human 108V and 108M catechol O-methyltransferase.
    Rutherford K; Le Trong I; Stenkamp RE; Parson WW
    J Mol Biol; 2008 Jun; 380(1):120-30. PubMed ID: 18486144
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Functional and structural characterization of a novel catechol-O-methyltransferase from Schizosaccharomyces pombe.
    Wang Q; Teng M; Li X
    IUBMB Life; 2019 Mar; 71(3):330-339. PubMed ID: 30501007
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-based drug design of catechol-O-methyltransferase inhibitors for CNS disorders.
    Ma Z; Liu H; Wu B
    Br J Clin Pharmacol; 2014 Mar; 77(3):410-20. PubMed ID: 23713800
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure of catechol O-methyltransferase.
    Vidgren J; Svensson LA; Liljas A
    Nature; 1994 Mar; 368(6469):354-8. PubMed ID: 8127373
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor.
    Tsuji E; Okazaki K; Takeda K
    Biochem Biophys Res Commun; 2009 Jan; 378(3):494-7. PubMed ID: 19056347
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application.
    Bonifácio MJ; Archer M; Rodrigues ML; Matias PM; Learmonth DA; Carrondo MA; Soares-Da-Silva P
    Mol Pharmacol; 2002 Oct; 62(4):795-805. PubMed ID: 12237326
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity.
    Lerner C; Masjost B; Ruf A; Gramlich V; Jakob-Roetne R; Zürcher G; Borroni E; Diederich F
    Org Biomol Chem; 2003 Jan; 1(1):42-9. PubMed ID: 12929389
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors.
    Ellermann M; Lerner C; Burgy G; Ehler A; Bissantz C; Jakob-Roetne R; Paulini R; Allemann O; Tissot H; Grünstein D; Stihle M; Diederich F; Rudolph MG
    Acta Crystallogr D Biol Crystallogr; 2012 Mar; 68(Pt 3):253-60. PubMed ID: 22349227
    [TBL] [Abstract][Full Text] [Related]  

  • 13.
    Czarnota S; Baxter NJ; Cliff MJ; Waltho JP; Scrutton NS; Hay S
    Biomol NMR Assign; 2017 Apr; 11(1):57-61. PubMed ID: 27981425
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease.
    Patel CN; Georrge JJ; Modi KM; Narechania MB; Patel DP; Gonzalez FJ; Pandya HA
    J Biomol Struct Dyn; 2018 Nov; 36(15):3938-3957. PubMed ID: 29281938
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The 108M polymorph of human catechol O-methyltransferase is prone to deformation at physiological temperatures.
    Rutherford K; Bennion BJ; Parson WW; Daggett V
    Biochemistry; 2006 Feb; 45(7):2178-88. PubMed ID: 16475806
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A hotspot of inactivation: The A22S and V108M polymorphisms individually destabilize the active site structure of catechol O-methyltransferase.
    Rutherford K; Daggett V
    Biochemistry; 2009 Jul; 48(27):6450-60. PubMed ID: 19435324
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Medicinal chemistry of catechol O-methyltransferase (COMT) inhibitors and their therapeutic utility.
    Kiss LE; Soares-da-Silva P
    J Med Chem; 2014 Nov; 57(21):8692-717. PubMed ID: 25080080
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Prospecting for new catechol-
    da Silva IR; Parise MR; Pereira M; da Silva RA
    J Biomol Struct Dyn; 2021 Oct; 39(16):5872-5891. PubMed ID: 32691671
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).
    Lanier M; Ambrus G; Cole DC; Davenport R; Ellery J; Fosbeary R; Jennings AJ; Kadotani A; Kamada Y; Kamran R; Matsumoto S; Mizukami A; Okubo S; Okada K; Saikatendu K; Walsh L; Wu H; Hixon MS
    J Med Chem; 2014 Jun; 57(12):5459-63. PubMed ID: 24847974
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols.
    Zhang L; Jin Y; Chen M; Huang M; Harvey RG; Blair IA; Penning TM
    J Biol Chem; 2011 Jul; 286(29):25644-54. PubMed ID: 21622560
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.