366 related articles for article (PubMed ID: 25085554)
1. The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.
Tam JH; Seah C; Pasternak SH
Mol Brain; 2014 Aug; 7():54. PubMed ID: 25085554
[TBL] [Abstract][Full Text] [Related]
2. Imaging the Intracellular Trafficking of APP with Photoactivatable GFP.
Tam JH; Pasternak SH
J Vis Exp; 2015 Oct; (105):e53153. PubMed ID: 26555118
[TBL] [Abstract][Full Text] [Related]
3. Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway.
Toh WH; Tan JZ; Zulkefli KL; Houghton FJ; Gleeson PA
Traffic; 2017 Mar; 18(3):159-175. PubMed ID: 28000370
[TBL] [Abstract][Full Text] [Related]
4. Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes.
Tang W; Tam JH; Seah C; Chiu J; Tyrer A; Cregan SP; Meakin SO; Pasternak SH
Mol Brain; 2015 Jul; 8():41. PubMed ID: 26170135
[TBL] [Abstract][Full Text] [Related]
5. Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.
Xiao Q; Yan P; Ma X; Liu H; Perez R; Zhu A; Gonzales E; Tripoli DL; Czerniewski L; Ballabio A; Cirrito JR; Diwan A; Lee JM
J Neurosci; 2015 Sep; 35(35):12137-51. PubMed ID: 26338325
[TBL] [Abstract][Full Text] [Related]
6. LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.
Brodeur J; Thériault C; Lessard-Beaudoin M; Marcil A; Dahan S; Lavoie C
Mol Neurodegener; 2012 Jun; 7():31. PubMed ID: 22734645
[TBL] [Abstract][Full Text] [Related]
7. Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.
Lorenzen A; Samosh J; Vandewark K; Anborgh PH; Seah C; Magalhaes AC; Cregan SP; Ferguson SS; Pasternak SH
Mol Brain; 2010 Apr; 3():11. PubMed ID: 20409323
[TBL] [Abstract][Full Text] [Related]
8. Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).
Park HJ; Shabashvili D; Nekorchuk MD; Shyqyriu E; Jung JI; Ladd TB; Moore BD; Felsenstein KM; Golde TE; Kim SH
J Biol Chem; 2012 Nov; 287(48):40629-40. PubMed ID: 23043097
[TBL] [Abstract][Full Text] [Related]
9. The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells.
Kuentzel SL; Ali SM; Altman RA; Greenberg BD; Raub TJ
Biochem J; 1993 Oct; 295 ( Pt 2)(Pt 2):367-78. PubMed ID: 8240235
[TBL] [Abstract][Full Text] [Related]
10. Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease.
Lefort R; Pozueta J; Shelanski M
J Neurosci; 2012 Aug; 32(31):10674-85. PubMed ID: 22855816
[TBL] [Abstract][Full Text] [Related]
11. Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation.
Vorobyeva AG; Lee R; Miller S; Longen C; Sharoni M; Kandelwal PJ; Kim FJ; Marenda DR; Saunders AJ
J Biol Chem; 2014 Nov; 289(48):33258-74. PubMed ID: 25281744
[TBL] [Abstract][Full Text] [Related]
12. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.
Tomita S; Kirino Y; Suzuki T
J Biol Chem; 1998 Mar; 273(11):6277-84. PubMed ID: 9497354
[TBL] [Abstract][Full Text] [Related]
13. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb.
Sun M; Asghar SZ; Zhang H
Neurobiol Dis; 2016 Sep; 93():1-11. PubMed ID: 27072891
[TBL] [Abstract][Full Text] [Related]
14. CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.
Furusawa K; Takasugi T; Chiu YW; Hori Y; Tomita T; Fukuda M; Hisanaga SI
J Biol Chem; 2019 Jul; 294(28):10886-10899. PubMed ID: 31138646
[TBL] [Abstract][Full Text] [Related]
15. Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis.
Chia PZ; Toh WH; Sharples R; Gasnereau I; Hill AF; Gleeson PA
Traffic; 2013 Sep; 14(9):997-1013. PubMed ID: 23773724
[TBL] [Abstract][Full Text] [Related]
16. Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons.
Maesako M; Houser MCQ; Turchyna Y; Wolfe MS; Berezovska O
J Neurosci; 2022 Jan; 42(1):145-154. PubMed ID: 34810230
[TBL] [Abstract][Full Text] [Related]
17. CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-site APP cleaving protein 1 (BACE1).
Zhao Y; Wang Y; Hu J; Zhang X; Zhang YW
J Biol Chem; 2012 Mar; 287(14):11141-50. PubMed ID: 22351782
[TBL] [Abstract][Full Text] [Related]
18. The
Tan JZA; Gleeson PA
J Biol Chem; 2019 Feb; 294(5):1618-1631. PubMed ID: 30545942
[TBL] [Abstract][Full Text] [Related]
19. A nontoxigenic form of Shiga toxin 2 suppresses the production of amyloid β by altering the intracellular transport of amyloid precursor protein through its receptor-binding B-subunit.
Sato W; Watanabe-Takahashi M; Hamabata T; Furukawa K; Funamoto S; Nishikawa K
Biochem Biophys Res Commun; 2021 Jun; 557():247-253. PubMed ID: 33894410
[TBL] [Abstract][Full Text] [Related]
20. Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells.
Bustamante HA; Rivera-Dictter A; Cavieres VA; Muñoz VC; González A; Lin Y; Mardones GA; Burgos PV
PLoS One; 2013; 8(12):e83096. PubMed ID: 24376644
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]