139 related articles for article (PubMed ID: 25112279)
1. Pharmacological inhibition of DGAT1 induces sebaceous gland atrophy in mouse and dog skin while overt alopecia is restricted to the mouse.
Floettmann E; Lees D; Seeliger F; Jones HB
Toxicol Pathol; 2015 Apr; 43(3):376-83. PubMed ID: 25112279
[TBL] [Abstract][Full Text] [Related]
2. Identification and characterization of sebaceous gland atrophy-sparing DGAT1 inhibitors.
Muise ES; Zhu Y; Verras A; Karanam BV; Gorski J; Weingarth D; Lin HV; Hwa J; Thompson JR; Hu G; Liu J; He S; DeVita RJ; Shen DM; Pinto S
PLoS One; 2014; 9(2):e88908. PubMed ID: 24558447
[TBL] [Abstract][Full Text] [Related]
3. Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first-time-in-human single-dose study.
Denison H; Nilsson C; Kujacic M; Löfgren L; Karlsson C; Knutsson M; Eriksson JW
Diabetes Obes Metab; 2013 Feb; 15(2):136-43. PubMed ID: 22950654
[TBL] [Abstract][Full Text] [Related]
4. Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial.
Denison H; Nilsson C; Löfgren L; Himmelmann A; Mårtensson G; Knutsson M; Al-Shurbaji A; Tornqvist H; Eriksson JW
Diabetes Obes Metab; 2014 Apr; 16(4):334-43. PubMed ID: 24118885
[TBL] [Abstract][Full Text] [Related]
5. Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands.
Chen HC; Smith SJ; Tow B; Elias PM; Farese RV
J Clin Invest; 2002 Jan; 109(2):175-81. PubMed ID: 11805129
[TBL] [Abstract][Full Text] [Related]
6. ACAT-selective and nonselective DGAT1 inhibition: adrenocortical effects--a cross-species comparison.
Floettmann JE; Buckett LK; Turnbull AV; Smith T; Hallberg C; Birch A; Lees D; Jones HB
Toxicol Pathol; 2013; 41(7):941-50. PubMed ID: 23427273
[TBL] [Abstract][Full Text] [Related]
7. Intestine-targeted DGAT1 inhibition improves obesity and insulin resistance without skin aberrations in mice.
Tsuda N; Kumadaki S; Higashi C; Ozawa M; Shinozaki M; Kato Y; Hoshida K; Kikuchi S; Nakano Y; Ogawa Y; Furusako S
PLoS One; 2014; 9(11):e112027. PubMed ID: 25405858
[TBL] [Abstract][Full Text] [Related]
8. Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
Barlind JG; Bauer UA; Birch AM; Birtles S; Buckett LK; Butlin RJ; Davies RD; Eriksson JW; Hammond CD; Hovland R; Johannesson P; Johansson MJ; Kemmitt PD; Lindmark BT; Morentin Gutierrez P; Noeske TA; Nordin A; O'Donnell CJ; Petersson AU; Redzic A; Turnbull AV; Vinblad J
J Med Chem; 2012 Dec; 55(23):10610-29. PubMed ID: 23116186
[TBL] [Abstract][Full Text] [Related]
9. Doxorubicin-induced alopecia is associated with sebaceous gland degeneration.
Selleri S; Seltmann H; Gariboldi S; Shirai YF; Balsari A; Zouboulis CC; Rumio C
J Invest Dermatol; 2006 Apr; 126(4):711-20. PubMed ID: 16470179
[TBL] [Abstract][Full Text] [Related]
10. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.
Cao J; Zhou Y; Peng H; Huang X; Stahler S; Suri V; Qadri A; Gareski T; Jones J; Hahm S; Perreault M; McKew J; Shi M; Xu X; Tobin JF; Gimeno RE
J Biol Chem; 2011 Dec; 286(48):41838-41851. PubMed ID: 21990351
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.
Chen HC; Farese RV
Arterioscler Thromb Vasc Biol; 2005 Mar; 25(3):482-6. PubMed ID: 15569818
[TBL] [Abstract][Full Text] [Related]
12. Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol.
Morentin Gutierrez P; Yates J; Nilsson C; Birtles S
Pharmacol Res Perspect; 2019 Apr; 7(2):e00465. PubMed ID: 30899516
[TBL] [Abstract][Full Text] [Related]
13. Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.
Maciejewski BS; LaPerle JL; Chen D; Ghosh A; Zavadoski WJ; McDonald TS; Manion TB; Mather D; Patterson TA; Hanna M; Watkins S; Gibbs EM; Calle RA; Steppan CM
Am J Physiol Gastrointest Liver Physiol; 2013 Jun; 304(11):G958-69. PubMed ID: 23558010
[TBL] [Abstract][Full Text] [Related]
14. Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?
Rittié L; Tejasvi T; Harms PW; Xing X; Nair RP; Gudjonsson JE; Swindell WR; Elder JT
J Invest Dermatol; 2016 Sep; 136(9):1792-1800. PubMed ID: 27312025
[TBL] [Abstract][Full Text] [Related]
15. Sebaceous gland atrophy due to seborrheic dermatitis in a patient with alopecia: A potential pitfall.
Zengin S; Guthrie J; Zoumberos N; Hamza M; Shalin SC
J Cutan Pathol; 2024 Jul; 51(7):513-517. PubMed ID: 38613429
[TBL] [Abstract][Full Text] [Related]
16. Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.
Liu J; Gorski JN; Gold SJ; Chen D; Chen S; Forrest G; Itoh Y; Marsh DJ; McLaren DG; Shen Z; Sonatore L; Carballo-Jane E; Craw S; Guan X; Karanam B; Sakaki J; Szeto D; Tong X; Xiao J; Yoshimoto R; Yu H; Roddy TP; Balkovec J; Pinto S
Obesity (Silver Spring); 2013 Jul; 21(7):1406-15. PubMed ID: 23671037
[TBL] [Abstract][Full Text] [Related]
17. Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.
Sundberg JP; Shen T; Fiehn O; Rice RH; Silva KA; Kennedy VE; Gott NE; Dionne LA; Bechtold LS; Murray SA; Kuiper R; Pratt CH
PLoS One; 2018; 13(10):e0205775. PubMed ID: 30372477
[TBL] [Abstract][Full Text] [Related]
18. Insights from the asebia mouse: a molecular sebaceous gland defect leading to cicatricial alopecia.
Stenn KS
J Cutan Pathol; 2001 Oct; 28(9):445-7. PubMed ID: 11553309
[TBL] [Abstract][Full Text] [Related]
19. Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.
Liu L; Trent CM; Fang X; Son NH; Jiang H; Blaner WS; Hu Y; Yin YX; Farese RV; Homma S; Turnbull AV; Eriksson JW; Hu SL; Ginsberg HN; Huang LS; Goldberg IJ
J Biol Chem; 2014 Oct; 289(43):29881-91. PubMed ID: 25157099
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors.
Kandre S; Bhagat PR; Reddy MM; Dalal R; Dixit A; Deshmukh NJ; Anthony J; Bose J; Anupindi R; Sharma R; Gupte A
Eur J Med Chem; 2014 May; 79():203-15. PubMed ID: 24735646
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]