205 related articles for article (PubMed ID: 25117203)
1. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays.
Dean RA; Fam HK; An J; Choi K; Shimizu Y; Jones SJ; Boerkoel CF; Interthal H; Pfeifer TA
J Biomol Screen; 2014 Dec; 19(10):1372-82. PubMed ID: 25117203
[TBL] [Abstract][Full Text] [Related]
2. TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.
Fam HK; Walton C; Mitra SA; Chowdhury M; Osborne N; Choi K; Sun G; Wong PC; O'Sullivan MJ; Turashvili G; Aparicio S; Triche TJ; Bond M; Pallen CJ; Boerkoel CF
Mol Cancer Res; 2013 Oct; 11(10):1179-92. PubMed ID: 23913164
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.
Hu DX; Tang WL; Zhang Y; Yang H; Wang W; Agama K; Pommier Y; An LK
J Med Chem; 2021 Jun; 64(11):7617-7629. PubMed ID: 34008967
[TBL] [Abstract][Full Text] [Related]
4. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
Zhang XR; Wang HW; Tang WL; Zhang Y; Yang H; Hu DX; Ravji A; Marchand C; Kiselev E; Ofori-Atta K; Agama K; Pommier Y; An LK
J Med Chem; 2018 Nov; 61(22):9908-9930. PubMed ID: 30336023
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
Conda-Sheridan M; Reddy PV; Morrell A; Cobb BT; Marchand C; Agama K; Chergui A; Renaud A; Stephen AG; Bindu LK; Pommier Y; Cushman M
J Med Chem; 2013 Jan; 56(1):182-200. PubMed ID: 23259865
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
Zakharova O; Luzina O; Zakharenko A; Sokolov D; Filimonov A; Dyrkheeva N; Chepanova A; Ilina E; Ilyina A; Klabenkova K; Chelobanov B; Stetsenko D; Zafar A; Eurtivong C; Reynisson J; Volcho K; Salakhutdinov N; Lavrik O
Bioorg Med Chem; 2018 Aug; 26(15):4470-4480. PubMed ID: 30076000
[TBL] [Abstract][Full Text] [Related]
7. 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
Dexheimer TS; Gediya LK; Stephen AG; Weidlich I; Antony S; Marchand C; Interthal H; Nicklaus M; Fisher RJ; Njar VC; Pommier Y
J Med Chem; 2009 Nov; 52(22):7122-31. PubMed ID: 19883083
[TBL] [Abstract][Full Text] [Related]
8. Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
Dexheimer TS; Antony S; Marchand C; Pommier Y
Anticancer Agents Med Chem; 2008 May; 8(4):381-9. PubMed ID: 18473723
[TBL] [Abstract][Full Text] [Related]
9. Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.
Murai J; Marchand C; Shahane SA; Sun H; Huang R; Zhang Y; Chergui A; Ji J; Doroshow JH; Jadhav A; Takeda S; Xia M; Pommier Y
DNA Repair (Amst); 2014 Sep; 21():177-82. PubMed ID: 24794403
[TBL] [Abstract][Full Text] [Related]
10. Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment.
Beretta GL; Cossa G; Gatti L; Zunino F; Perego P
Curr Med Chem; 2010; 17(15):1500-8. PubMed ID: 20166932
[TBL] [Abstract][Full Text] [Related]
11. Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.
Perego P; Cossa G; Tinelli S; Corna E; Carenini N; Gatti L; De Cesare M; Ciusani E; Zunino F; Luison E; Canevari S; Zaffaroni N; Beretta GL
Biochem Pharmacol; 2012 Jan; 83(1):27-36. PubMed ID: 21978643
[TBL] [Abstract][Full Text] [Related]
12. Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.
Zakharenko A; Luzina O; Koval O; Nilov D; Gushchina I; Dyrkheeva N; Švedas V; Salakhutdinov N; Lavrik O
J Nat Prod; 2016 Nov; 79(11):2961-2967. PubMed ID: 27933897
[TBL] [Abstract][Full Text] [Related]
13. Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity.
Zakharenko A; Dyrkheeva N; Lavrik O
Med Res Rev; 2019 Jul; 39(4):1427-1441. PubMed ID: 31004352
[TBL] [Abstract][Full Text] [Related]
14. Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides.
Jun JH; Kumar V; Dexheimer TS; Wedlich I; Nicklaus MC; Pommier Y; Malhotra SV
Eur J Pharm Sci; 2018 Jan; 111():337-348. PubMed ID: 29037996
[TBL] [Abstract][Full Text] [Related]
15. Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1.
Antony S; Marchand C; Stephen AG; Thibaut L; Agama KK; Fisher RJ; Pommier Y
Nucleic Acids Res; 2007; 35(13):4474-84. PubMed ID: 17576665
[TBL] [Abstract][Full Text] [Related]
16. Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.
Huang SN; Pommier Y; Marchand C
Expert Opin Ther Pat; 2011 Sep; 21(9):1285-92. PubMed ID: 21843105
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors.
Nguyen TX; Abdelmalak M; Marchand C; Agama K; Pommier Y; Cushman M
J Med Chem; 2015 Apr; 58(7):3188-208. PubMed ID: 25811317
[TBL] [Abstract][Full Text] [Related]
18. A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2
Li-Zhulanov NS; Zakharenko AL; Chepanova AA; Patel J; Zafar A; Volcho KP; Salakhutdinov NF; Reynisson J; Leung IKH; Lavrik OI
Molecules; 2018 Sep; 23(10):. PubMed ID: 30261631
[TBL] [Abstract][Full Text] [Related]
19. Biochemical assays for the discovery of TDP1 inhibitors.
Marchand C; Huang SY; Dexheimer TS; Lea WA; Mott BT; Chergui A; Naumova A; Stephen AG; Rosenthal AS; Rai G; Murai J; Gao R; Maloney DJ; Jadhav A; Jorgensen WL; Simeonov A; Pommier Y
Mol Cancer Ther; 2014 Aug; 13(8):2116-26. PubMed ID: 25024006
[TBL] [Abstract][Full Text] [Related]
20. Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.
Salomatina OV; Popadyuk II; Zakharenko AL; Zakharova OD; Fadeev DS; Komarova NI; Reynisson J; Arabshahi HJ; Chand R; Volcho KP; Salakhutdinov NF; Lavrik OI
Molecules; 2018 Mar; 23(3):. PubMed ID: 29562592
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]