BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

275 related articles for article (PubMed ID: 25117711)

  • 1. Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage.
    Tollini LA; Jin A; Park J; Zhang Y
    Cancer Cell; 2014 Aug; 26(2):235-47. PubMed ID: 25117711
    [TBL] [Abstract][Full Text] [Related]  

  • 2. MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail.
    Sanford JD; Yang J; Han J; Tollini LA; Jin A; Zhang Y
    BMC Mol Cell Biol; 2021 Sep; 22(1):46. PubMed ID: 34551723
    [TBL] [Abstract][Full Text] [Related]  

  • 3. MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation
    Yang J; Jin A; Han J; Chen X; Zheng J; Zhang Y
    Cancer Res; 2021 Feb; 81(4):898-909. PubMed ID: 33277368
    [TBL] [Abstract][Full Text] [Related]  

  • 4. MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
    Chinnam M; Xu C; Lama R; Zhang X; Cedeno CD; Wang Y; Stablewski AB; Goodrich DW; Wang X
    PLoS Genet; 2022 May; 18(5):e1010171. PubMed ID: 35588102
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
    Pant V; Xiong S; Iwakuma T; Quintás-Cardama A; Lozano G
    Proc Natl Acad Sci U S A; 2011 Jul; 108(29):11995-2000. PubMed ID: 21730132
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase.
    Xu C; Fan CD; Wang X
    Oncogene; 2015 Jan; 34(3):281-9. PubMed ID: 24413081
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.
    Clegg HV; Itahana Y; Itahana K; Ramalingam S; Zhang Y
    PLoS One; 2012; 7(5):e38212. PubMed ID: 22666487
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.
    Zhao K; Yang Y; Zhang G; Wang C; Wang D; Wu M; Mei Y
    EMBO Rep; 2018 Feb; 19(2):305-319. PubMed ID: 29295817
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.
    Itahana K; Mao H; Jin A; Itahana Y; Clegg HV; Lindström MS; Bhat KP; Godfrey VL; Evan GI; Zhang Y
    Cancer Cell; 2007 Oct; 12(4):355-66. PubMed ID: 17936560
    [TBL] [Abstract][Full Text] [Related]  

  • 10. p53 regulation: teamwork between RING domains of Mdm2 and MdmX.
    Wang X
    Cell Cycle; 2011 Dec; 10(24):4225-9. PubMed ID: 22134240
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice.
    Tian H; Tackmann NR; Jin A; Zheng J; Zhang Y
    J Biol Chem; 2017 Dec; 292(52):21614-21622. PubMed ID: 29123033
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mouse modelling of the MDM2/MDMX-p53 signalling axis.
    Tackmann NR; Zhang Y
    J Mol Cell Biol; 2017 Feb; 9(1):34-44. PubMed ID: 28096294
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells.
    Wade M; Li YC; Matani AS; Braun SM; Milanesi F; Rodewald LW; Wahl GM
    Oncogene; 2012 Nov; 31(45):4789-97. PubMed ID: 22266850
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
    Nie J; Xie P; Liu L; Xing G; Chang Z; Yin Y; Tian C; He F; Zhang L
    J Biol Chem; 2010 Jul; 285(30):22818-30. PubMed ID: 20484049
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.
    He Y; Tollini L; Kim TH; Itahana Y; Zhang Y
    Cell Cycle; 2014; 13(13):2101-9. PubMed ID: 24804778
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mdm2 and MdmX partner to regulate p53.
    Wang X; Jiang X
    FEBS Lett; 2012 May; 586(10):1390-6. PubMed ID: 22673503
    [TBL] [Abstract][Full Text] [Related]  

  • 17. RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
    Fu X; Yucer N; Liu S; Li M; Yi P; Mu JJ; Yang T; Chu J; Jung SY; O'Malley BW; Gu W; Qin J; Wang Y
    Proc Natl Acad Sci U S A; 2010 Mar; 107(10):4579-84. PubMed ID: 20173098
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.
    Pant V; Xiong S; Jackson JG; Post SM; Abbas HA; Quintás-Cardama A; Hamir AN; Lozano G
    Genes Dev; 2013 Sep; 27(17):1857-67. PubMed ID: 23973961
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity.
    Yang L; Song T; Cheng Q; Chen L; Chen J
    Mol Cell Biol; 2019 Feb; 39(4):. PubMed ID: 30455251
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.
    Humpton TJ; Nomura K; Weber J; Magnussen HM; Hock AK; Nixon C; Dhayade S; Stevenson D; Huang DT; Strathdee D; Blyth K; Vousden KH
    Genes Dev; 2021 Jan; 35(1-2):117-132. PubMed ID: 33334825
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.