BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

176 related articles for article (PubMed ID: 25127103)

  • 1. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.
    Kumar VP; Cisneros JA; Frey KM; Castellanos-Gonzalez A; Wang Y; Gangjee A; White AC; Jorgensen WL; Anderson KS
    Bioorg Med Chem Lett; 2014 Sep; 24(17):4158-61. PubMed ID: 25127103
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors.
    Kumar VP; Frey KM; Wang Y; Jain HK; Gangjee A; Anderson KS
    Bioorg Med Chem Lett; 2013 Oct; 23(19):5426-8. PubMed ID: 23927969
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening.
    Ruiz V; Czyzyk DJ; Valhondo M; Jorgensen WL; Anderson KS
    Bioorg Med Chem Lett; 2019 Jun; 29(11):1413-1418. PubMed ID: 30929953
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors.
    Ruiz VG; Czyzyk DJ; Kumar VP; Jorgensen WL; Anderson KS
    Bioorg Med Chem Lett; 2020 Aug; 30(16):127292. PubMed ID: 32631514
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.
    Czyzyk DJ; Valhondo M; Deiana L; Tirado-Rives J; Jorgensen WL; Anderson KS
    Eur J Med Chem; 2019 Dec; 183():111673. PubMed ID: 31536894
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium.
    Mukerjee A; Iyidogan P; Castellanos-Gonzalez A; Cisneros JA; Czyzyk D; Ranjan AP; Jorgensen WL; White AC; Vishwanatha JK; Anderson KS
    Bioorg Med Chem Lett; 2015; 25(10):2065-7. PubMed ID: 25900220
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis.
    Vargo MA; Martucci WE; Anderson KS
    Biochem J; 2009 Feb; 417(3):757-64. PubMed ID: 18851711
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase.
    Sharma H; Landau MJ; Sullivan TJ; Kumar VP; Dahlgren MK; Jorgensen WL; Anderson KS
    Bioorg Med Chem Lett; 2014 Feb; 24(4):1232-5. PubMed ID: 24440298
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
    Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF
    J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.
    Gangjee A; Jain HD; Kisliuk RL
    Bioorg Med Chem Lett; 2005 May; 15(9):2225-30. PubMed ID: 15837298
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation.
    Landau MJ; Sharma H; Anderson KS
    Protein Sci; 2013 Sep; 22(9):1161-73. PubMed ID: 23813474
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.
    Gangjee A; Jain HD; Phan J; Guo X; Queener SF; Kisliuk RL
    Bioorg Med Chem; 2010 Jan; 18(2):953-61. PubMed ID: 20056546
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents.
    Tian C; Wang M; Han Z; Fang F; Zhang Z; Wang X; Liu J
    Eur J Med Chem; 2017 Sep; 138():630-643. PubMed ID: 28711701
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.
    Anderson AC
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2005 Mar; 61(Pt 3):258-62. PubMed ID: 16511011
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O; Schormann N; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.
    Gangjee A; Li W; Kisliuk RL; Cody V; Pace J; Piraino J; Makin J
    J Med Chem; 2009 Aug; 52(15):4892-902. PubMed ID: 19719239
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).
    Gangjee A; Jain HD; Phan J; Lin X; Song X; McGuire JJ; Kisliuk RL
    J Med Chem; 2006 Feb; 49(3):1055-65. PubMed ID: 16451071
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
    Gangjee A; Vidwans A; Elzein E; McGuire JJ; Queener SF; Kisliuk RL
    J Med Chem; 2001 Jun; 44(12):1993-2003. PubMed ID: 11384244
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.
    Gangjee A; Yang J; McGuire JJ; Kisliuk RL
    Bioorg Med Chem; 2006 Dec; 14(24):8590-8. PubMed ID: 16990006
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior.
    Atreya CE; Anderson KS
    J Biol Chem; 2004 Apr; 279(18):18314-22. PubMed ID: 14966126
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.